Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002871
Disease: Anemia
Anemia
0.090 Biomarker disease BEFREE Inosine triphosphatase (ITPA) genetic variants are strongly associated with ribavirin (RBV)-induced anaemia during pegylated interferon (PEG-IFN) plus RBV therapy. 24750345 2014
CUI: C0002871
Disease: Anemia
Anemia
0.090 GeneticVariation disease BEFREE The most commonly observed side effects of telaprevir therapy are anaemia to a greater degree than that observed with PEG-IFN/ribavirin alone; eczematous rash, which can be severe in a minority of patients; and anorectal discomfort. 23286840 2013
CUI: C0002871
Disease: Anemia
Anemia
0.090 Biomarker disease BEFREE A variation in the propensity of CC carriers to develop anaemia prompted us to look for additional predictors of anaemia during pegylated interferon (PEG-IFN) and RBV. 22571903 2012
CUI: C0002871
Disease: Anemia
Anemia
0.090 Biomarker disease BEFREE Ribavirin (RBV)-induced anemia is a serious side effect of pegylated interferon (PEG-IFN) plus RBV therapy which is the standard care most effective for hepatitis C virus (HCV) infection. 22052220 2012
CUI: C0002871
Disease: Anemia
Anemia
0.090 Biomarker disease BEFREE The inosine triphosphatase (ITPA) genotype is associated with ribavirin-induced anemia and pegylated interferon α (PEG IFN-α)-induced platelet reduction during PEG IFN-α plus ribavirin combination therapy. 22554247 2012
CUI: C0002871
Disease: Anemia
Anemia
0.090 GeneticVariation disease BEFREE Genotype 1b chronic hepatitis C patients (n=132) treated with pegylated interferon (PEG-IFN)-α and RBV for 48 weeks were genotyped for ITPA rs1127354 and examined for anaemia and treatment outcome. 21817190 2011
CUI: C0002871
Disease: Anemia
Anemia
0.090 Biomarker disease BEFREE Polymorphisms of the inosine triphosphatase (ITPA) gene influence anemia during pegylated interferon (PEG-IFN) and ribavirin (RBV) therapy, but their effects during triple therapy with PEG-IFN, RBV, and telaprevir are not known. 21246582 2011
CUI: C0002871
Disease: Anemia
Anemia
0.090 GeneticVariation disease BEFREE We evaluated the association between the casual ITPA variants and on-treatment anemia in a well-characterized cohort of genotype 2/3 patients treated with variable-duration pegylated interferon alfa-2b (PEG-IFN-α2b) and RBV. 21274861 2011
CUI: C0002871
Disease: Anemia
Anemia
0.090 Biomarker disease BEFREE Hepatitis C virus (HCV) treatment is frequently complicated by anemia from ribavirin (RBV)-related hemolysis and peginterferon-alfa (PEG-IFN)-related bone marrow suppression. 20723545 2010