SERPINE1, serpin family E member 1, 5054

N. diseases: 770; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.360 AlteredExpression group BEFREE In the current work we have analyzed the regulation of vitronectin by transforming growth factor-beta 1 (TGF beta 1) in this hepatoma cell line by Northern hybridization, polypeptide and immunoprecipitation analyses and compared the response to another TGF beta-regulated gene, plasminogen activator inhibitor (PAI-1). 1712727 1991
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.360 AlteredExpression group BEFREE Cotransfection of human or rat PAI-1 promoter luciferase constructs with expression vectors for wild-type USF-2 or USF-2 mutants in human HepG2 and rat H4IIE cells as well as in primary rat hepatocytes revealed that the effects of USF on PAI-1 expression depend on the cell type rather than the promoter context and that the USF-specific region domain of USF accounts for the observed cell type-specific effects. 16330554 2006
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.360 AlteredExpression group BEFREE Protein expression in hepatoma HepG2 cells stimulated by TGF-beta(1) was analyzed by western blotting and plasminogen activator inhibitor type 1 (PAI-1) transcriptional activity in HepG2 cells was evaluated. 19793165 2010
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.360 Biomarker group CTD_human Loss of metallothionein predisposes mice to diethylnitrosamine-induced hepatocarcinogenesis by activating NF-kappaB target genes. 21159647 2010
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.360 Biomarker group BEFREE We have analyzed the regulation of PAI-1 mRNA accumulation by interleukin (IL)-1, IL-6, and dexamethasone, known mediators of the acute phase response, in HepG2 cells, a highly differentiated human hepatoma cell line that produces a broad spectrum of acute phase proteins including PAI-1. 8034668 1994
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.360 Biomarker group BEFREE The hepatoma cell line Hep G2 has been shown to synthesize PAI-1 in response to insulin. 8387542 1993
CUI: C0023903
Disease: Liver neoplasms
Liver neoplasms
0.360 Biomarker group BEFREE Thus, these data clearly show that LRP is the major cell-surface receptor responsible for t-PA.PAI-1 complex binding and endocytosis on human hepatoma HepG2 cells and extend the multifunctional nature of LRP as an endocytosis receptor for several structurally and functionally distinct ligands. 8389767 1993