SERPINE1, serpin family E member 1, 5054

N. diseases: 770; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma
0.300 GeneticVariation disease BEFREE A PAI-1 functional polymorphism (rs1799768, 4G5G) was characterized in subjects with poorly controlled asthma enrolled in a randomized clinical trial of soy isoflavones (n = 265). 30707970 2019
CUI: C0004096
Disease: Asthma
Asthma
0.300 GeneticVariation disease BEFREE We estimated the relationship of the PAI-1 risk allele with FEV1/FVC by multivariate linear regression, stratified by asthma status. 28543872 2017
CUI: C0004096
Disease: Asthma
Asthma
0.300 GeneticVariation disease BEFREE The objective is to investigate the frequency of PAI-1 gene polymorphism (4G/5G) in patients with a lung ventilation dysfunction in asthma and allergic rhinitis. 28258374 2017
CUI: C0004096
Disease: Asthma
Asthma
0.300 AlteredExpression disease BEFREE These novel findings suggest that asthma itself is associated with decreased CRR and reduced fibrinolytic potential resulting from alterations in clot architecture and elevated levels of plasma FXIII and PAI-1. 27659252 2017
CUI: C0004096
Disease: Asthma
Asthma
0.300 GeneticVariation disease BEFREE We evaluated the independent and joint effects of a PAI-1 gain of function polymorphism and bronchiolitis / Respiratory Syncytial Virus (RSV) or other lower respiratory infections (LRI) within the first 2 years of life on asthma risk, asthma exacerbations and lung function. 27556405 2016
CUI: C0004096
Disease: Asthma
Asthma
0.300 GeneticVariation disease BEFREE It has been established that PAI-1 4G allele may be a genetic risk factor for childhood asthma but ACE gene I/D polymorphisms do not play a role in the development of asthma in the sample of Turkish children. 22361338 2015
CUI: C0004096
Disease: Asthma
Asthma
0.300 AlteredExpression disease BEFREE Vitamin D has also been implicated in asthma through its effects on the obesity, bacillus Calmettee Guérin (BCG) vaccination and high vitamin D level, vitamin D supplement, checkpoint protein kinase 1 (Chk1), plasminogen activator inhibitor-1 (PAI-1) and gamma delta T cells (gdT). 22532985 2012
CUI: C0004096
Disease: Asthma
Asthma
0.300 GeneticVariation disease BEFREE This meta-analysis suggested that the -675 4G/5G polymorphism of PAI-1 gene was a risk factor of asthma. 22479620 2012
CUI: C0004096
Disease: Asthma
Asthma
0.300 Biomarker disease BEFREE These results indicate that PAI-1 is strongly involved in the pathogenesis of asthma, and intra-airway administration of PAI-1-siRNA may be able to become a new therapeutic approach for asthma. 21926267 2011
CUI: C0004096
Disease: Asthma
Asthma
0.300 GeneticVariation disease BEFREE We studied associations between a functional SERPINE1 -675 4G/5G promoter polymorphism and asthma development, severity and response to ICSs. 21478212 2011
CUI: C0004096
Disease: Asthma
Asthma
0.300 GeneticVariation disease BEFREE Our study suggests that Turkish children with asthma or allergic rhinitis have a higher prevalence of PAI-1 4G allele compared with their healthy peers. 19063817 2009
CUI: C0004096
Disease: Asthma
Asthma
0.300 Biomarker disease BEFREE In a mouse ovalbumin (OVA) asthma model, we increased plasminogen activator activity in the lung by administering exogenous uPA or by using mice genetically deficient in the uPA inhibitor plasminogen activator inhibitor-1 (PAI-1) to assess the role of this system in asthma pathogenesis. 19098125 2009
CUI: C0004096
Disease: Asthma
Asthma
0.300 Biomarker disease BEFREE Recent studies suggest that PAI-1 may promote the development of asthma by regulating airway remodelling, airway hyperresponsiveness (AHR), and allergic inflammation. 19438580 2009
CUI: C0004096
Disease: Asthma
Asthma
0.300 Biomarker disease BEFREE To characterize the mechanisms of the 4G/5G-dependent PAI-1 expression in mast cells (MCs), a major source of PAI-1 and key effector cells in asthma. 18234320 2008
CUI: C0004096
Disease: Asthma
Asthma
0.300 Biomarker disease BEFREE To assess the ability of asthmatic airway epithelial cells (AECs) to repair mechanically induced wounds and to investigate the role that plasminogen activator inhibitor-1 plays in the repair process. 19037965 2008
CUI: C0004096
Disease: Asthma
Asthma
0.300 GeneticVariation disease LHGDN Both the C allele of CD14 and the 4G allele of SERPINE1 were more frequently encountered in HDM-allergic asthmatic patients than in healthy control individuals. 18714537 2008
CUI: C0004096
Disease: Asthma
Asthma
0.300 Biomarker disease RGD Tissue plasminogen activator activity was significantly decreased in asthmatic animals (4.48 +/- 0.4 vs. 6.7 +/- 0.3 ng/ml for OVA/OVA and OVA/VEH; p < 0.05), and PAI-1 activity was statistically significantly higher in asthma rats (0.8 +/- 0.05 vs. 0.5 +/- 0.03 ng/ml for OVA/OVA vs. OVA/VEH; p < 0.05). alpha2-Antiplasmin was higher in rats receiving OVA sensitization than in those that were sham sensitized (p < 0.05). 18594148 2008
CUI: C0004096
Disease: Asthma
Asthma
0.300 GeneticVariation disease BEFREE The -675 4G/5G plasminogen activator inhibitor-1 (PAI-1) polymorphism is linked with asthma and bronchial hyperreactivity. 17579282 2007
CUI: C0004096
Disease: Asthma
Asthma
0.300 Biomarker disease BEFREE The present findings suggest a synergistic interaction between FCER1B and PAI-1 genes in asthma susceptibility. 16839401 2006
CUI: C0004096
Disease: Asthma
Asthma
0.300 Biomarker disease LHGDN Studies with transgenic mice have revealed a functional role for PAI-1 in wound healing, atherosclerosis, metabolic disturbances such as obesity and insulin resistance, tumor angiogenesis, chronic stress, bone remodeling, asthma, rheumatoid arthritis, fibrosis, glomerulonephritis and sepsis. 15634264 2005
CUI: C0004096
Disease: Asthma
Asthma
0.300 Biomarker disease BEFREE In summary, PAI-1 may play an important role in the pathogenesis of asthma and further studies evaluating the mechanisms of PAI-1 action may lead to the development of a novel therapeutic target for the treatment and prevention of asthma. 14734792 2004
CUI: C0004096
Disease: Asthma
Asthma
0.300 GeneticVariation disease BEFREE DNA taken from subjects with clinically manifested asthma and other allergic diseases (n = 207) and from reference ethnically age-gender-matched unrelated subjects (n = 186) was examined for base deletions/insertions in the PAI-1 gene. 11972486 2002
CUI: C0004096
Disease: Asthma
Asthma
0.300 Biomarker disease BEFREE These results suggest that PAI-1 could play an important role in airway remodeling of asthma, and inhibition of PAI-1 activity could represent a novel therapeutic approach in the management of airway remodeling. 10975829 2000