|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, our findings demonstrate that PAI-1 is a new target of ACT001, the inhibition of PAI-1 induces glioma inhibition, and ACT001 has a synergistic effect with cisplatin through the inhibition of the PAI-1/PI3K/AKT pathway.
|
31591377 |
2019 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results of microarray analysis, qRT-PCR and western blot showed that miR-1275 was low-expressed while SERPINE1 was high-expressed in glioma.
|
30024092 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The activation of potential PAI-1/LRP1 axis with purified PAI-1 promoted increased phosphorylation of STAT3 and subsequently exocytosis in MCs.These findings indicate the influence of the PAI-1/LRP1 axis on the recruitment of MCs in glioma.
|
26164207 |
2015 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that CXCL12/CXCR4 signaling in glioma cells may be another mechanism for these cells to express PAI-1, which may be involved in angiogenesis and tumor invasion in brain tumors.
|
19336886 |
2009 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
These results suggest that the serum PAI-1 level can be a marker for the prediction of histological grade in intracerebral glioma.
|
18383878 |
2008 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Glioma cells were indeed a major source of tPA and PAI-1; these molecules were significantly more expressed in glioma than in patient's blood cells.
|
16357523 |
2006 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We report that PAI-1 stimulates expression and release of vascular endothelial growth factor (VEGF) in the human glioma cell line D54Mg, and thereby stimulates the proliferation of human umbilical vein endothelial cells (HUVEC) in vitro.
|
14980508 |
2004 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
D-dimer, lp (a), homocysteine, VEGF, tPA, and PAI-1 plasma levels were significantly higher in patients with glioma than in healthy controls, whereas patients having neurological nonneoplastic disease had plasma values of these molecules not significantly different from healthy controls.
|
14977830 |
2004 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
LHGDN |
The results show that overexpression of PAI-1 can inhibit glioma cell motility and invasion through extracellular matrix (ECM) components, like laminin and collagen, but does not inhibit tumor cell invasion in a three-dimensional invasion assay, simulating normal brain tissue having a different ECM and interstitial composition.
|
12856717 |
2003 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The results show that overexpression of PAI-1 can inhibit glioma cell motility and invasion through extracellular matrix (ECM) components, like laminin and collagen, but does not inhibit tumor cell invasion in a three-dimensional invasion assay, simulating normal brain tissue having a different ECM and interstitial composition.
|
12856717 |
2003 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The fibrinolytic activities of conditioned medium and cell lysates from human glioma cell lines, A172, T98G, U87 and TM1 were studied by fibrin plate zymography. mRNA expression of tissue plasminogen activator (tPA), urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitors (PAI-1, PAI-2) was measured by Northern blot analysis.
|
12241114 |
2002 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two of the SPARC-induced genes, BIGH3 (irreversible by dox) and PAI-1 (reversible by dox) were further studied in additional SPARC-transfected clones, human astrocytoma tissues, and human glioma cell lines by RT-PCR and Northern blot analyses.
|
12510773 |
2002 |