SERPINE1, serpin family E member 1, 5054

N. diseases: 770; N. variants: 23
Disease: Heart failure ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018801
Disease: Heart failure
Heart failure 		0.350 Biomarker disease BEFREE Our results demonstrate that the heart failure milieu caused a 2-fold enrichment of extracellular matrix proteins (ECM) like biglycan, versican, collagen XII, and angiogenic factors like heparan sulfate proteoglycan 2, plasminogen activator inhibitor 1 in the secretome. 30575044 2019
CUI: C0018801
Disease: Heart failure
Heart failure 		0.350 Biomarker disease BEFREE In models adjusted for clinical risk factors of heart failure, 2 biomarkers were significantly associated with incident HFpEF: UACR (hazard ratio [HR], 1.33; 95% CI, 1.20-1.48; P < .001) and natriuretic peptides (HR, 1.27; 95% CI, 1.16-1.40; P < .001), with suggestive associations for high-sensitivity troponin (HR, 1.11; 95% CI, 1.03-1.19; P = .008), plasminogen activator inhibitor 1 (HR, 1.22; 95% CI, 1.03-1.45; P = .02), and fibrinogen (HR, 1.12; 95% CI, 1.03-1.22; P = .01). 29322198 2018
CUI: C0018801
Disease: Heart failure
Heart failure 		0.350 AlteredExpression disease BEFREE PAI-1 activity rise was independently related to heart failure, thrombus aspiration, and body weight. 29972733 2018
CUI: C0018801
Disease: Heart failure
Heart failure 		0.350 Biomarker disease BEFREE Prognostic significance of tPA/PAI-1 complex in patients with heart failure and preserved ejection fraction. 27975104 2017
CUI: C0018801
Disease: Heart failure
Heart failure 		0.350 Biomarker disease BEFREE Thus, increased VCAM-1 and PAI-1, and decreased eNOS phosphorylation through the TLR4/NFκB/p38 pathway, may be associated with atrial thrombogenesis in the heart failure mice model. 23754516 2014
CUI: C0018801
Disease: Heart failure
Heart failure 		0.350 Biomarker disease CTD_human Vascular and thrombogenic effects of pulmonary exposure to Libby amphibole. 22352330 2012