PARKINSON DISEASE, LATE-ONSET
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mutation screening of PARK2 was performed in 225 Serbian PD patients (143 males and 82 females) with disease onset before 50 years and/or positive family history with apparent AR inheritance.
|
30099245 |
2018 |
PARKINSON DISEASE, LATE-ONSET
|
0.400 |
GeneticVariation
|
disease |
UNIPROT |
Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson's disease-like pathology.
|
29311685 |
2018 |
PARKINSON DISEASE, LATE-ONSET
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The percentage of TH(+) neurons was decreased in Parkinson's disease (PD) patient-derived neurons carrying various mutations in PARK2 compared with an age-matched control subject.
|
25843045 |
2015 |
PARKINSON DISEASE, LATE-ONSET
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, axonal alpha-synuclein deposits were absent in epicardial tissue of the PARK2 mutation carrier while they were present in the two PD patients.
|
25960264 |
2015 |
PARKINSON DISEASE, LATE-ONSET
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Moreover, Miro1 turnover on damaged mitochondria is altered in Parkinson disease (PD) patient-derived fibroblasts containing a pathogenic mutation in the PARK2 gene (encoding Parkin).
|
24671417 |
2014 |
PARKINSON DISEASE, LATE-ONSET
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the 12 coding exons of PARK2 gene in 16 early onset PD patients of South Indian ethnicity.
|
22766139 |
2012 |
PARKINSON DISEASE, LATE-ONSET
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A functional SNP (rs9347683) in the promoter region of the parkin gene had been implicated as a risk factor in older Parkinson's disease (PD) patients.
|
21176923 |
2011 |
PARKINSON DISEASE, LATE-ONSET
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The identification of copy number variations in the Parkin gene in healthy control individuals suggests no major role of these variations in late onset Parkinson's disease.
|
21734494 |
2011 |
PARKINSON DISEASE, LATE-ONSET
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We present results of mutation screening of PRKN gene in 93 Iranian Parkinson's disease (PD) patients with average age at onset (AAO) of 42.2 years.
|
21322020 |
2011 |
PARKINSON DISEASE, LATE-ONSET
|
0.400 |
GeneticVariation
|
disease |
UNIPROT |
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy.
|
19966284 |
2010 |
PARKINSON DISEASE, LATE-ONSET
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Early- and late-onset Parkinson's disease (EOPD and LOPD) have been associated with mutations in the PARKIN gene.
|
19909784 |
2010 |
PARKINSON DISEASE, LATE-ONSET
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of the study was to explore the prevalence and differences of nonmotor symptoms (NMSs) in patients with young-onset Parkinson's disease (YOPD) with and without mutations in the Parkin gene and late-onset Parkinson's disease (LOPD).
|
20629119 |
2010 |
PARKINSON DISEASE, LATE-ONSET
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Parkin gene variations in late-onset Parkinson's disease: comparison between Norwegian and German cohorts.
|
16367892 |
2006 |
PARKINSON DISEASE, LATE-ONSET
|
0.400 |
GeneticVariation
|
disease |
UNIPROT |
Heterozygosity for a mutation in the parkin gene leads to later onset Parkinson disease.
|
12629236 |
2003 |
PARKINSON DISEASE, LATE-ONSET
|
0.400 |
GeneticVariation
|
disease |
UNIPROT |
Parkin mutations and susceptibility alleles in late-onset Parkinson's disease.
|
12730996 |
2003 |
PARKINSON DISEASE, LATE-ONSET
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The parkin gene is not a major susceptibility locus for typical late-onset Parkinson's disease.
|
11487208 |
2001 |
PARKINSON DISEASE, LATE-ONSET
|
0.400 |
Biomarker
|
disease |
BEFREE |
The parkin gene is not involved in late-onset Parkinson's disease.
|
11468333 |
2001 |
PARKINSON DISEASE, LATE-ONSET
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We report polymorphism of the parkin gene in 160 sporadic Parkinson's disease (PD) patients and controls.
|
10319889 |
1999 |