GLRX2, glutaredoxin 2, 51022

N. diseases: 7; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2985280
Disease: Blood Protein Measurement
Blood Protein Measurement
0.100 GeneticVariation phenotype GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
CUI: C0338656
Disease: Impaired cognition
Impaired cognition
0.010 Biomarker disease BEFREE Moreover, HFD-caused cognitive dysfunction was further promoted in GRX2 knockout mice. 31382130 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.010 AlteredExpression disease BEFREE At enrollment, sepsis was associated with significant increases in the expression of mRNAs related to redox metabolism (myeloperoxidase, 64-fold; PRDX3, 2.6-fold; SOD2, 2.2-fold) and redox-responsive genes (FOXM1, 21-fold; SELS, 16-fold; GLRX2, 3.4-fold). 29540208 2018
CUI: C0243026
Disease: Sepsis
Sepsis
0.010 AlteredExpression disease BEFREE At enrollment, sepsis was associated with significant increases in the expression of mRNAs related to redox metabolism (myeloperoxidase, 64-fold; PRDX3, 2.6-fold; SOD2, 2.2-fold) and redox-responsive genes (FOXM1, 21-fold; SELS, 16-fold; GLRX2, 3.4-fold). 29540208 2018
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.010 AlteredExpression disease BEFREE Grx2 levels were significantly higher in patients with metabolic syndrome. 25004829 2014
CUI: C0018799
Disease: Heart Diseases
Heart Diseases
0.010 Biomarker group BEFREE To date no investigations have addressed the potential role of Glrx2 in cardiac disorders. 18076901 2008
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.010 Biomarker disease BEFREE The hearts from Glrx2 transgenic mice displayed significantly improved contractile performance and reduced myocardial infarct size and cardiomyocyte apoptosis. 18076901 2008