Asthma
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
Two SNPs, rs1544791 (PDE4D) and rs3806932 (TSLP), were more strongly associated with the high smoking history subgroup than with asthma or any other subgroups.
|
27058054 |
2016 |
Asthma
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
Our rank-based genome-wide analysis revealed for the first time an association of RYR2 variants with asthma and replicated previously discovered PDE4D asthma gene across human populations.
|
23829686 |
2013 |
Asthma
|
0.470 |
Biomarker
|
disease |
BEFREE |
An important genetic component to asthma susceptibility has long been recognized, most recently through the identification of several genes (e.g., ORMDL3, PDE4D, HLA-DQ, and TLE4) via genome-wide association studies.
|
23181788 |
2012 |
Asthma
|
0.470 |
Biomarker
|
disease |
BEFREE |
Long-acting β(2)-agonists are now contraindicated as monotherapy for asthma, and increased PDE4D has been speculated to contribute to this phenomenon.
|
22101762 |
2012 |
Asthma
|
0.470 |
GeneticVariation
|
disease |
GWASDB |
Identification of IL6R and chromosome 11q13.5 as risk loci for asthma.
|
21907864 |
2011 |
Asthma
|
0.470 |
Biomarker
|
disease |
CTD_human |
β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D.
|
21611147 |
2011 |
Asthma
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
We sought to search for new variants associated with asthma and attempt to replicate the association with four loci reported previously (ORMDL3, PDE4D, DENND1B and IL1RL1).
|
21150878 |
2011 |
Asthma
|
0.470 |
Biomarker
|
disease |
BEFREE |
Gene-based analyses that included all available SNPs in each gene found associations (P < .05) with both phenotypes for several genes: neuronal growth regulator 1 (NEGR1); roundabout, axon guidance receptor, homolog 1 (ROBO1); diacylglycerol kinase, gamma (DGKG); Fas apoptotic inhibitory molecule 2 (FAIM2); fat mass and obesity associated (FTO); and carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 (CHST8) among the BMI GWAS genes; interleukin 1 receptor-like 1 / interleukin 18 receptor 1 (IL1RL1/IL18R1), dipeptidyl-peptidase 10 (DPP10), phosphodiesterase 4D (PDE4D), V-myb myeloblastosis viral oncogene homolog (MYB), PDE10A, IL33, and especially protein tyrosine phosphatase, receptor type D (PTPRD) among the asthma GWAS genes; and protein kinase C, alpha (PRKCA) among the BMI and asthma candidate genes.
|
20816195 |
2010 |
Asthma
|
0.470 |
GeneticVariation
|
disease |
GWASDB |
Asthma-susceptibility variants identified using probands in case-control and family-based analyses.
|
20698975 |
2010 |
Asthma
|
0.470 |
GeneticVariation
|
disease |
GWASDB |
The phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) gene (PDE4D) is a regulator of airway smooth-muscle contractility, and PDE4 inhibitors have been developed as medications for asthma.
|
19426955 |
2009 |
Asthma
|
0.470 |
Biomarker
|
disease |
CTD_human |
The phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) gene (PDE4D) is a regulator of airway smooth-muscle contractility, and PDE4 inhibitors have been developed as medications for asthma.
|
19426955 |
2009 |
Asthma
|
0.470 |
Biomarker
|
disease |
BEFREE |
The phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) gene (PDE4D) is a regulator of airway smooth-muscle contractility, and PDE4 inhibitors have been developed as medications for asthma.
|
19426955 |
2009 |
Asthma
|
0.470 |
GeneticVariation
|
disease |
GWASCAT |
The phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila) gene (PDE4D) is a regulator of airway smooth-muscle contractility, and PDE4 inhibitors have been developed as medications for asthma.
|
19426955 |
2009 |