|
Chronic eosinophilic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Patients with PDGFRA-rearranged hematopoietic neoplasms typically present with chronic eosinophilic leukemia and rarely with acute myeloid leukemia or T-lymphoblastic lymphoma.
|
29505472 |
2018 |
|
Chronic eosinophilic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The clinical laboratory work-up confirmed secondary HE in 25 (20%) patients; myeloid/lymphoid neoplasms with rearrangements of PDGFRA (n = 9) or PDGFRB (n = 2) (9%); HE associated with a well-defined myeloid neoplasm in 8 (6%); and abnormal bone marrow and/or molecular genetic abnormalities consistent with chronic eosinophilic leukemia (CEL), not otherwise specified (NOS) in 21 (17%) patients.
|
30105844 |
2018 |
|
Chronic eosinophilic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Compound 15i potently inhibited the proliferation of PDGFRα driving Chronic Eosinophilic Leukemia (CEL) cell line EOL-1 through strong blockage of PDGFRα mediated signaling pathways, arresting cell cycle progression, and induction of apoptosis.
|
29544149 |
2018 |
|
Chronic eosinophilic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
FIP1L1-PDGFRA is a leukemogenic fusion kinase that causes chronic eosinophilic leukemia.
|
27960034 |
2017 |
|
Chronic eosinophilic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The Fip1-like1 (FIP1L1)-platelet-derived growth factor receptor alpha (PDGFRA) (F/P) oncogene can cause chronic eosinophilic leukemia (CEL), but requires IL-5 cytokine participation.
|
29029406 |
2017 |
|
Chronic eosinophilic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Severe Prolonged Cough as Presenting Manifestation of FIP1L1-PDGFRA+ Chronic Eosinophilic Leukaemia: A Widely Ignored Association.
|
27164940 |
2016 |
|
Chronic eosinophilic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
To our knowledge, this is the first report of a patient with GEH associated with FIP1L1-PDGFRA-positive chronic eosinophilic leukemia.
|
25923837 |
2015 |
|
Chronic eosinophilic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
FIP1L1-PDGFRA is a constitutively activated kinase described in chronic eosinophilic leukemia (CEL) and hypereosinophilic syndrome (HES).
|
25761934 |
2015 |
|
Chronic eosinophilic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, S116836 is active against WT and T674I FIP1L1-PDGFRα-expressing cells, and may be a prospective agent for the treatment of HES/CEL.
|
25431951 |
2014 |
|
Chronic eosinophilic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Ponatinib is a pan-FIP1L1-PDGFRα inhibitor, and clinical trials are warranted to investigate its efficacy in imatinib-resistant CEL.
|
24472312 |
2014 |
|
Chronic eosinophilic leukemia
|
0.400 |
FusionGene
|
disease |
ORPHANET |
FIP1L1-PDGFRA-Positive Chronic Eosinophilic Leukemia: A Low-Burden Disease with Dramatic Response to Imatinib - A Report of 5 Cases from South India.
|
24764730 |
2014 |
|
Chronic eosinophilic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Oncostatin M is a FIP1L1/PDGFRA-dependent mediator of cytokine production in chronic eosinophilic leukemia.
|
23621172 |
2013 |
|
Chronic eosinophilic leukemia
|
0.400 |
FusionGene
|
disease |
ORPHANET |
Identification of JAK2 as a mediator of FIP1L1-PDGFRA-induced eosinophil growth and function in CEL.
|
22523564 |
2012 |
|
Chronic eosinophilic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The dysregulated tyrosine kinases, D816V KIT and FIP1L1-PDGFRA, are the prototypic oncogenic lesions resulting in systemic mastocytosis (SM) and chronic eosinophilic leukemia, respectively.
|
22449623 |
2012 |
|
Chronic eosinophilic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Identification of JAK2 as a mediator of FIP1L1-PDGFRA-induced eosinophil growth and function in CEL.
|
22523564 |
2012 |
|
Chronic eosinophilic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The introduction of JAK2 mutation testing has changed dramatically the diagnostic algorithms for myeloproliferative neoplasms (MPNs) but there is still a place for conventional cytogenetic analysis in the initial work-up of MPN cases, particularly as this group of myeloid disorders has been expanded to include chronic eosinophilic leukaemia and myeloid neoplasms with abnormalities of the PDGFRA, PDGFRB, and FGFR1 genes.
|
21431636 |
2011 |
|
Chronic eosinophilic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In FIP1L1/PDGFRA-positive chronic eosinophilic leukaemia (CEL), neither the SM nor the CEL component of the disease exhibited the KIT mutation.
|
20112369 |
2010 |
|
Chronic eosinophilic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this paper, we screened 77 patients to estimate the frequency of FIP1L1-PDGFRA transcript among patients with unexplained, long-term hypereosinophilia exceeding 1.5 x 10(9)/L and to analyse the clinical and serological features in F/P+ CEL population.
|
19728396 |
2010 |
|
Chronic eosinophilic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The murine model and the in vitro development system of FIP1L1/PDGFR alpha-positive mast cells revealed the interaction between FIP1L1/PDGFR alpha, IL-5 and stem cell factor in the development of HES/CEL/SM.
|
20523072 |
2010 |
|
Chronic eosinophilic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The identification of novel drug-resistant FIP1L1-PDGFRA variants may help to develop the next generation of target-directed compounds for CEL/HES and other leukemias.
|
19210352 |
2009 |
|
Chronic eosinophilic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Chronic myeloid neoplasm with eosinophilia and abnormalities of platelet-derived growth factor receptor alpha (PDGFRA), referred to until 2008 as chronic eosinophilic leukemia, is distinguished from hypereosinophilic syndrome (HES), if accompanied by genetic abnormalities that enable to determine eosinophil clonality.
|
20010473 |
2009 |
|
Chronic eosinophilic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Chronic eosinophilic leukemia (CEL) is a rare myeloproliferative neoplasm characterized by the FIP1L1-PDGFRA fusion gene, variant PDGFRA fusions or other genetic lesions.
|
19212337 |
2009 |
|
Chronic eosinophilic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
As such, the fusion gene FIP1L1/PDGFRA was found as a cause of CEL in a significant proportion of patients initially diagnosed as having HES.
|
19494514 |
2009 |
|
Chronic eosinophilic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, a recent report noted two cases with the association of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia and T-cell lymphoblastic lymphoma (T-LBL).
|
18028420 |
2008 |
|
Chronic eosinophilic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
FIP1L1-PDGFRA positive chronic eosinophilic leukaemia and associated central nervous system involvement.
|
18256119 |
2008 |