PDYN, prodynorphin, 5173

N. diseases: 197; N. variants: 13
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036572
Disease: Seizures
Seizures
0.320 AlteredExpression phenotype BEFREE AAV-delivered preprodynorphin expression is focally and neuronally restricted and release is dependent on high-frequency stimulation, as it occurs at the onset of seizures. 31486590 2019
CUI: C0036572
Disease: Seizures
Seizures
0.320 Biomarker phenotype BEFREE The prodynorphin gene (PDYN) encoding the anticonvulsant peptide dynorphin is a strong candidate for a seizure suppressor gene and thus a possible modulator of susceptibility to temporal lobe epilepsy. 11835385 2002
CUI: C0036572
Disease: Seizures
Seizures
0.320 Therapeutic phenotype CTD_human [The role of the opiate mechanisms of the hippocampus and substantia nigra in the behavioral and convulsive disorders in picrotoxin-induced kindling]. 1675896 1991