Liver carcinoma
|
0.470 |
Biomarker
|
disease |
BEFREE |
In conclusion, it was implied that LINC00707 can lead to HCC progression through sponging miR-206 and modulating CDK14.
|
30488589 |
2019 |
Liver carcinoma
|
0.470 |
Biomarker
|
disease |
BEFREE |
MiR-877-5p suppresses cell growth, migration and invasion by targeting cyclin dependent kinase 14 and predicts prognosis in hepatocellular carcinoma.
|
29863248 |
2018 |
Liver carcinoma
|
0.470 |
GeneticVariation
|
disease |
GWASCAT |
Genome-Wide Association Study Identifies a New Locus at 7q21.13 Associated with Hepatitis B Virus-Related Hepatocellular Carcinoma.
|
29246937 |
2018 |
Liver carcinoma
|
0.470 |
AlteredExpression
|
disease |
BEFREE |
The serine/threonine-protein kinase PFTAIRE 1 (PFTK1) is a member of the cyclin‑dependent kinase family that is highly expressed in several malignant tumors, including hepatocellular carcinoma, esophageal, breast and gastric cancers, and glioma.
|
28498444 |
2017 |
Liver carcinoma
|
0.470 |
AlteredExpression
|
disease |
BEFREE |
Recent studies show that PFTK1 is highly expressed in several malignant tumors such as hepatocellular carcinoma, esophageal cancer, breast cancer, and involved in regulation of cell cycle, tumors proliferation, migration, and invasion that further influence the prognosis of tumors.
|
26488471 |
2015 |
Liver carcinoma
|
0.470 |
Biomarker
|
disease |
CTD_human |
The results suggest that seven of these genes, including VCAM1 and CDK14, may confer growth and infiltration capacity to HCC cells.
|
22922871 |
2012 |
Liver carcinoma
|
0.470 |
AlteredExpression
|
disease |
BEFREE |
Here, we showed from tissue microarray that common upregulations of PFTK1 in primary HCC tumors (n=133/180) correlated significantly with early age onset (40 years), advance tumor grading and presence of microvascular invasion (P0.05).
|
21577206 |
2011 |
Liver carcinoma
|
0.470 |
Biomarker
|
disease |
BEFREE |
Our study stemmed from an earlier investigation where we demonstrated that PFTK1 kinase conferred cell migratory advantages in human hepatocellular carcinoma (HCC) cells.
|
21184254 |
2011 |
Liver carcinoma
|
0.470 |
Biomarker
|
disease |
BEFREE |
Quantitative reverse transcription (RT)-PCR evaluation further indicated upregulation of a single candidate gene, PFTK1, that correlated significantly with both advanced metastatic HCCs (P = 0.032) and tumor microvascular invasion (P = 0.012).
|
17559150 |
2007 |
Ovarian Mucinous Adenocarcinoma
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Hepatitis B
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-Wide Association Study Identifies a New Locus at 7q21.13 Associated with Hepatitis B Virus-Related Hepatocellular Carcinoma.
|
29246937 |
2018 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Taken together, our findings suggest a mechanism by which DYRK2 controls CDK14 expression to regulate tumor cell proliferation and invasion in breast cancer.
|
29193658 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, knockdown of E2F5 and PFTK1 mimicked the tumor-suppressive effects of miR-1-3p overexpression on PCa progression.
|
30185212 |
2018 |
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
MiR-877-5p suppresses cell growth, migration and invasion by targeting cyclin dependent kinase 14 and predicts prognosis in hepatocellular carcinoma.
|
29863248 |
2018 |
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Taken together, our findings suggest a mechanism by which DYRK2 controls CDK14 expression to regulate tumor cell proliferation and invasion in breast cancer.
|
29193658 |
2018 |
Leukemia, Myelocytic, Acute
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.
|
27903959 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
High PFTK1 expression in cancerous cells was detected in 92 of the CRC specimens (51.40%), and high levels of PFTK1 were associated with tumor node metastasis (TNM) stage (P=0.042), tumor classification (P=0.022) and preoperative carcinoembryonic antigen (CEA) level (P<0.001).
|
28498444 |
2017 |
ESTRONE MEASUREMENT
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+ breast cancer: genome-wide association studies of the estrone pathway.
|
28429243 |
2017 |
Androstenedione measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+ breast cancer: genome-wide association studies of the estrone pathway.
|
28429243 |
2017 |
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Overexpression of miR-216a significantly suppressed cell proliferation, migration and invasion in vivo and in vitro by inhibiting CDK14 production.
|
29022909 |
2017 |
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Expressions of downstream molecules in Wnt signaling pathway as well as the proliferation, invasion and migration ability of the SKOV3 cells were reduced when CDK14 was inhibited (all p < 0.05).
|
27505004 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
PFTK1 is a member of the cyclin-dependent kinase (CDK) family and is upregulated in many types of tumors.
|
27458094 |
2016 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Statistical analysis showed the expression of PFTK1 was associated with multiple clinicopathological factors, including tumor grade, FIGO stage, lymph node metastatis, Ki-67 expression and predicted a poor prognosis of EOC patients.
|
26772918 |
2016 |
Tumor Cell Invasion
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Taken together, these results suggest that knockdown of PFTK1 inhibited the proliferation and invasion of colon cancer cells as well as the EMT progress by suppressing the Sonic hedgehog signaling pathway.
|
27458094 |
2016 |