PGR, progesterone receptor, 5241

N. diseases: 392; N. variants: 33
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1849699
Disease: Progesterone Resistance
Progesterone Resistance
0.400 Biomarker disease BEFREE PGR is predicted to be involved in progesterone resistance with a recessive inheritance pattern and is, therefore, not considered as being causal. 30483911 2019
CUI: C1849699
Disease: Progesterone Resistance
Progesterone Resistance
0.400 Biomarker disease BEFREE Progesterone receptor deficiency causes progesterone resistance. 30994890 2019
CUI: C1849699
Disease: Progesterone Resistance
Progesterone Resistance
0.400 GeneticVariation disease BEFREE These cells are also deficient in PGR, leading to progesterone resistance and defective retinoid synthesis. 30809650 2019
CUI: C1849699
Disease: Progesterone Resistance
Progesterone Resistance
0.400 Biomarker disease BEFREE Epigenetic changes in <i>PGR-A</i> and <i>PGR-B</i> may be related to progesterone resistance of endometriosis-related infertility. 30782101 2019
CUI: C1849699
Disease: Progesterone Resistance
Progesterone Resistance
0.400 AlteredExpression disease BEFREE Therefore, our study demonstrated that miR-194-3p contributes to progesterone resistance in endometriosis, which hinders fertility by repressing the levels of PR and decidualization in the EuE. 29762665 2018
CUI: C1849699
Disease: Progesterone Resistance
Progesterone Resistance
0.400 AlteredExpression disease BEFREE We find large-scale gene expression studies in eutopic tissue, indicative of progesterone resistance, are often contradictory, potentially due to the dynamic nature of this tissue, whereas suppressed progesterone receptor expression is supported in ectopic but not eutopic tissue. 29934050 2018
CUI: C1849699
Disease: Progesterone Resistance
Progesterone Resistance
0.400 GeneticVariation disease BEFREE Genetic causes of progesterone resistance include progesterone receptor gene polymorphisms, altered microRNA expression, and epigenetic modifications to progesterone receptors and their targets. 28423456 2017
CUI: C1849699
Disease: Progesterone Resistance
Progesterone Resistance
0.400 AlteredExpression disease BEFREE Uterine-specific deletion of Shp2 exhibits reduced progesterone receptor (PR) expression and progesterone resistance, which derails normal uterine receptivity, leading to complete implantation failure in mice. 28424251 2017
CUI: C1849699
Disease: Progesterone Resistance
Progesterone Resistance
0.400 AlteredExpression disease BEFREE Progesterone resistance has been observed in the endometrium of women with this disease, as evidenced by alterations in progesterone-responsive gene and protein expression. cAMPResponse Element-Binding 3-like protein 1 (Creb3l1) has previously been identified as a progesterone receptor (PR) target gene in mouse uterus via high density DNA microarray analysis. 26917262 2016
CUI: C1849699
Disease: Progesterone Resistance
Progesterone Resistance
0.400 Biomarker disease BEFREE Progesterone receptor deficiency leads to progesterone resistance, resulting in decreased retinol uptake and retinoic acid production and altered retinoic acid action. 26036904 2015
CUI: C1849699
Disease: Progesterone Resistance
Progesterone Resistance
0.400 Biomarker disease BEFREE The aim of this review is to provide an overview of endometrial progesterone resistance in women with PCOS; to present the PR structure, its different isoforms, and their expression in the endometrium; to illustrate the possible regulation of PR and PR-mediated signaling in progesterone resistance in women with PCOS; and to discuss current clinical treatments for atypical endometrial hyperplasia and endometrial carcinoma in women with PCOS and accompanying progesterone resistance. 24405633 2014
CUI: C1849699
Disease: Progesterone Resistance
Progesterone Resistance
0.400 Biomarker disease BEFREE Loss of KLF9 coregulation of endometrial stromal PGR-responsive gene networks may underlie progesterone resistance in endometriosis. 22259059 2012
CUI: C1849699
Disease: Progesterone Resistance
Progesterone Resistance
0.400 AlteredExpression disease BEFREE A severely high ERβ-to-ERα ratio in endometriotic stromal cells is associated with suppressed progesterone receptor and increased cyclo-oxygenase-2 levels contributing to progesterone resistance and inflammation. 22271293 2012
CUI: C1849699
Disease: Progesterone Resistance
Progesterone Resistance
0.400 Biomarker disease BEFREE In this review, we propose a molecular model that may be responsible for changes in ERbeta and ERalpha leading to PR loss and progesterone resistance in endometriosis. 20104427 2010
CUI: C1849699
Disease: Progesterone Resistance
Progesterone Resistance
0.400 AlteredExpression disease BEFREE The molecular basis of progesterone resistance in endometriosis may be related to an overall reduction in the levels of progesterone receptor (PR). 20108182 2010
CUI: C1849699
Disease: Progesterone Resistance
Progesterone Resistance
0.400 AlteredExpression disease BEFREE Together the data suggest that the proposed progesterone resistance in endometrium from women with endometriosis derives, in part, from impaired expression of the PR coactivator, Hic-5, in endometrial tissue and cultured endometrial stromal fibroblasts. 19389829 2009
CUI: C1849699
Disease: Progesterone Resistance
Progesterone Resistance
0.400 AlteredExpression disease BEFREE We speculate that a significantly increased ratio of ERbeta:ERalpha in endometriotic tissues may also suppress progesterone receptor expression and contribute to progesterone resistance. 19001520 2009
CUI: C1849699
Disease: Progesterone Resistance
Progesterone Resistance
0.400 AlteredExpression disease BEFREE The molecular basis of progesterone resistance in endometriosis may be related to an overall reduction in the levels of progesterone receptors (PRs) and the lack of the PR isoform named progesterone receptor B (PR-B). 16406281 2006
CUI: C1849699
Disease: Progesterone Resistance
Progesterone Resistance
0.400 AlteredExpression disease BEFREE This molecular evidence of progesterone resistance, together with the clinical observation of resistance of endometriosis to treatment with progestins, led us to determine the levels of progesterone receptor (PR) isoforms PR-A and PR-B in eutopic endometrial and extra-ovarian endometriotic tissues. 10946900 2000
CUI: C1849699
Disease: Progesterone Resistance
Progesterone Resistance
0.400 Biomarker disease CTD_human