Progesterone Resistance
|
0.400 |
Biomarker
|
disease |
BEFREE |
PGR is predicted to be involved in progesterone resistance with a recessive inheritance pattern and is, therefore, not considered as being causal.
|
30483911 |
2019 |
Progesterone Resistance
|
0.400 |
Biomarker
|
disease |
BEFREE |
Progesterone receptor deficiency causes progesterone resistance.
|
30994890 |
2019 |
Progesterone Resistance
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These cells are also deficient in PGR, leading to progesterone resistance and defective retinoid synthesis.
|
30809650 |
2019 |
Progesterone Resistance
|
0.400 |
Biomarker
|
disease |
BEFREE |
Epigenetic changes in <i>PGR-A</i> and <i>PGR-B</i> may be related to progesterone resistance of endometriosis-related infertility.
|
30782101 |
2019 |
Progesterone Resistance
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Therefore, our study demonstrated that miR-194-3p contributes to progesterone resistance in endometriosis, which hinders fertility by repressing the levels of PR and decidualization in the EuE.
|
29762665 |
2018 |
Progesterone Resistance
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We find large-scale gene expression studies in eutopic tissue, indicative of progesterone resistance, are often contradictory, potentially due to the dynamic nature of this tissue, whereas suppressed progesterone receptor expression is supported in ectopic but not eutopic tissue.
|
29934050 |
2018 |
Progesterone Resistance
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic causes of progesterone resistance include progesterone receptor gene polymorphisms, altered microRNA expression, and epigenetic modifications to progesterone receptors and their targets.
|
28423456 |
2017 |
Progesterone Resistance
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Uterine-specific deletion of Shp2 exhibits reduced progesterone receptor (PR) expression and progesterone resistance, which derails normal uterine receptivity, leading to complete implantation failure in mice.
|
28424251 |
2017 |
Progesterone Resistance
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Progesterone resistance has been observed in the endometrium of women with this disease, as evidenced by alterations in progesterone-responsive gene and protein expression. cAMPResponse Element-Binding 3-like protein 1 (Creb3l1) has previously been identified as a progesterone receptor (PR) target gene in mouse uterus via high density DNA microarray analysis.
|
26917262 |
2016 |
Progesterone Resistance
|
0.400 |
Biomarker
|
disease |
BEFREE |
Progesterone receptor deficiency leads to progesterone resistance, resulting in decreased retinol uptake and retinoic acid production and altered retinoic acid action.
|
26036904 |
2015 |
Progesterone Resistance
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of this review is to provide an overview of endometrial progesterone resistance in women with PCOS; to present the PR structure, its different isoforms, and their expression in the endometrium; to illustrate the possible regulation of PR and PR-mediated signaling in progesterone resistance in women with PCOS; and to discuss current clinical treatments for atypical endometrial hyperplasia and endometrial carcinoma in women with PCOS and accompanying progesterone resistance.
|
24405633 |
2014 |
Progesterone Resistance
|
0.400 |
Biomarker
|
disease |
BEFREE |
Loss of KLF9 coregulation of endometrial stromal PGR-responsive gene networks may underlie progesterone resistance in endometriosis.
|
22259059 |
2012 |
Progesterone Resistance
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A severely high ERβ-to-ERα ratio in endometriotic stromal cells is associated with suppressed progesterone receptor and increased cyclo-oxygenase-2 levels contributing to progesterone resistance and inflammation.
|
22271293 |
2012 |
Progesterone Resistance
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this review, we propose a molecular model that may be responsible for changes in ERbeta and ERalpha leading to PR loss and progesterone resistance in endometriosis.
|
20104427 |
2010 |
Progesterone Resistance
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The molecular basis of progesterone resistance in endometriosis may be related to an overall reduction in the levels of progesterone receptor (PR).
|
20108182 |
2010 |
Progesterone Resistance
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Together the data suggest that the proposed progesterone resistance in endometrium from women with endometriosis derives, in part, from impaired expression of the PR coactivator, Hic-5, in endometrial tissue and cultured endometrial stromal fibroblasts.
|
19389829 |
2009 |
Progesterone Resistance
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We speculate that a significantly increased ratio of ERbeta:ERalpha in endometriotic tissues may also suppress progesterone receptor expression and contribute to progesterone resistance.
|
19001520 |
2009 |
Progesterone Resistance
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The molecular basis of progesterone resistance in endometriosis may be related to an overall reduction in the levels of progesterone receptors (PRs) and the lack of the PR isoform named progesterone receptor B (PR-B).
|
16406281 |
2006 |
Progesterone Resistance
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This molecular evidence of progesterone resistance, together with the clinical observation of resistance of endometriosis to treatment with progestins, led us to determine the levels of progesterone receptor (PR) isoforms PR-A and PR-B in eutopic endometrial and extra-ovarian endometriotic tissues.
|
10946900 |
2000 |
Progesterone Resistance
|
0.400 |
Biomarker
|
disease |
CTD_human |
|
|
|