Disease: Unipolar Depression ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE Modification of the association between paroxetine serum concentration and SERT-occupancy by ABCB1 (P-glycoprotein) polymorphisms in major depressive disorder. 31634334 2020
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE Influence of ABCB1 polymorphisms and serum concentrations on venlafaxine response in patients with major depressive disorder. 28079463 2017
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE One-Year Follow-up of Children and Adolescents with Major Depressive Disorder: Relationship between Clinical Variables and Abcb1 Gene Polymorphisms. 27309038 2016
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE The authors genotyped 10 ABCB1 single-nucleotide polymorphisms (SNPs) in 683 patients with major depressive disorder treated for at least 2 weeks, of whom 576 completed 8 weeks of treatment with escitalopram, sertraline, or extended-release venlafaxine (all substrates for P-glycoprotein) in a large randomized, prospective, pragmatic trial. 25815420 2015
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 Biomarker disease PSYGENET The authors genotyped 10 ABCB1 single-nucleotide polymorphisms (SNPs) in 683 patients with major depressive disorder treated for at least 2 weeks, of whom 576 completed 8 weeks of treatment with escitalopram, sertraline, or extended-release venlafaxine (all substrates for P-glycoprotein) in a large randomized, prospective, pragmatic trial. 25815420 2015
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE In this meta-analysis, we systematically summarized 16 pharmacogenetic studies focused on the association of ABCB1 variants and antidepressant treatment outcome in patients with MD (overall n = 2695). 25847751 2015
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE Common genetic polymorphisms in the ABCB1 gene are associated with risk of major depressive disorder in male Portuguese individuals. 24200053 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE Our results suggested that C3435T polymorphism in the ABCB1 gene may be an indicator of the susceptibility to major depression, without a likely treatment response to citalopram in a Turkish population. 24911075 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 Biomarker disease PSYGENET Our results suggested that C3435T polymorphism in the ABCB1 gene may be an indicator of the susceptibility to major depression, without a likely treatment response to citalopram in a Turkish population. 24911075 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 Biomarker disease PSYGENET Common genetic polymorphisms in the ABCB1 gene are associated with risk of major depressive disorder in male Portuguese individuals. 24200053 2014
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 Biomarker disease PSYGENET In this study we investigated 36 single nucleotide polymorphisms within 10 genes previously associated with major depression and bipolar disorder, as well as with the response to their treatment (ABCB1, ABCB4, TAP2, CLOCK, CPLX1, CPLX2, SYN2, NRG1, 5HTR1A and GPRIN2). 23273899 2013
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE In order to resolve these inconsistencies, we conducted a study in a large cohort of patients with major depressive disorder with the aim to unravel the association of ABCB1 variants with adverse effects of antidepressants and in particular with selective serotonin reuptake inhibitors (SSRIs), which display affinity as substrate for P-gp. 22641028 2013
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 Biomarker disease PSYGENET In order to resolve these inconsistencies, we conducted a study in a large cohort of patients with major depressive disorder with the aim to unravel the association of ABCB1 variants with adverse effects of antidepressants and in particular with selective serotonin reuptake inhibitors (SSRIs), which display affinity as substrate for P-gp. 22641028 2013
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE Association between the functional polymorphism (C3435T) of the gene encoding P-glycoprotein (ABCB1) and major depressive disorder in the Japanese population. 22306099 2012
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE ABCB1 polymorphism predicts escitalopram dose needed for remission in major depression. 23188198 2012
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE ABCB1 gene polymorphisms are associated with the severity of major depressive disorder and its response to escitalopram treatment. 20859246 2011
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder. 17913323 2008
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.400 GeneticVariation disease BEFREE Our results indicated that MDR1 variants G2677T and C3435T are not associated with therapeutic response to paroxetine in patients with major depressive disorder. 18550244 2008