Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.400 Biomarker group BEFREE We investigated the impact of genetic polymorphisms in CYP3A4, CYP3A5, and ABCB1 on i.v. tacrolimus exposure and toxicity in adult patients receiving an allogeneic hematopoietic stem cell transplant for hematologic malignancies. 30597277 2019
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.400 Biomarker group BEFREE ABCB1 is one of the major drug efflux transporters that is known to cause multidrug resistance (MDR) in cancer patients receiving chemotherapy for the treatment of solid tumors and hematological malignancies. 30641875 2019
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.400 Biomarker group BEFREE Overexpression of a wide-spectrum of ATP-dependent efflux pumps, and in particular of ABCB1 (P-glycoprotein or MDR1) is a well-known resistance mechanism for a plethora of cancer chemotherapeutics including for example taxenes, anthracyclines, Vinca alkaloids, and epipodopyllotoxins, demonstrated by a large array of published papers, both in tumor cell lines and in a variety of tumors, including various solid tumors and hematological malignancies. 29145976 2017
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.400 Biomarker group CTD_human MDR1 C3435T polymorphism and cancer risk: a meta-analysis based on 39 case-control studies. 22311042 2012
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.400 Biomarker group BEFREE P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) localize in the microvessels forming the blood-tumor barrier in ependymomas. 20406235 2010
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.400 Biomarker group BEFREE Reference method for detection of Pgp mediated multidrug resistance in human hematological malignancies: a method validated by the laboratories of the French Drug Resistance Network. 16038729 2005
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.400 AlteredExpression group BEFREE Different mechanisms could sustain Imatinib resistance, including overexpression of MDR1, a gene already known to be responsible for multidrug resistance in other hematologic malignancies. 16157201 2005
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.400 AlteredExpression group BEFREE The data demonstrate that overexpression of MDR1 and MRP genes in hematological malignancies elevates in patients after chemotherapy and correlates with poor clinic prognosis and more frequent recurrences of the malignancies. 15560070 2004
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.400 Biomarker group BEFREE Targeting of P-gp by small-molecular compounds and/or antibodies is an effective strategy to overcome MDR in cancer, especially hematologic malignancies. 12708468 2003
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.400 AlteredExpression group BEFREE There have been a number of studies on the incidence of P-GP expression in tumor cells or tissues, where detectable level of P-GP has been found in all types of hematological malignancies. 12430927 2002
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.400 AlteredExpression group BEFREE The assay established will enable the quantification of MDR1 gene expression in blood samples from patients with leukemic hematologic malignancies and will be applicable to clinical laboratories as a routine test. 10695666 2000
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.400 GeneticVariation group BEFREE We therefore analyzed DNA from hematological malignancies for MDR1 promoter point mutations. 10500782 1999
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.400 Biomarker group BEFREE Resistance to chemotherapy-induced apoptosis and a multidrug-resistance (MDR) phenotype, mainly mediated by P-glycoprotein (P-gp), contribute to chemotherapy failure in hematologic malignancies. 10602414 1999
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.400 AlteredExpression group BEFREE MDR1 expression has been shown for numerous solid tumors and for virtually all hematologic malignancies. 9541688 1998
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.400 GeneticVariation group BEFREE Moreover, overexpression of the MDR1 gene has been shown to be associated closely with clinical outcome in various hematological malignancies, including acute myeloid leukemia (AML). 9834236 1998
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.400 Biomarker group BEFREE Based on the strong correlation between the imaging and flow cytometry and a statistical support toward the correlation between the imaging and RT-PCR, MIBI imaging may be used for the in vivo detection of Pgp in patients with hematologic malignancy. 9669392 1998
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.400 Biomarker group BEFREE A major mechanism of drug resistance documented to occur in hematologic malignancies is overexprssion of the MDR-1 gene product, P-glycoprotein (P-gp). 9408955 1997
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.400 GeneticVariation group BEFREE Prospective phase I, II, and III clinical trials using reversing agents in conjunction with chemotherapy in malignancies that express the MDR1 gene, such as the hematologic malignancies and breast cancer, are necessary before routine use of agents such as verapamil, quinidine, and cyclosporine, which carry innate toxicities. 7600845 1995
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.400 AlteredExpression group BEFREE The standardization of methods for P-gp, permitting large multicentric studies, and the results of randomized studies with modifier agents will help us know if mdr1 gene overexpression is of clinical importance in hematologic malignancies. 7642463 1995
CUI: C0376545
Disease: Hematologic Neoplasms
Hematologic Neoplasms
0.400 AlteredExpression group BEFREE Chemoresistance in some hematologic malignancies has been associated with overexpression of P-glycoprotein, which is encoded by the MDR1 gene (also known as PGY1). 8105101 1993