Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Integrin alpha 7 correlates with poor clinical outcomes, and it regulates cell proliferation, apoptosis and stemness via PTK2-PI3K-Akt signaling pathway in hepatocellular carcinoma.
|
31698037 |
2020 |
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Combination of aloin and metformin enhances the antitumor effect by inhibiting the growth and invasion and inducing apoptosis and autophagy in hepatocellular carcinoma through PI3K/AKT/mTOR pathway.
|
31830378 |
2020 |
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
A treatment incorporating circ-CDYL interference and traditional enzyme inhibitors targeting PI3K and HIF1AN demonstrated highly effective inhibition of stem-like characteristics and tumor growth in HCC.
|
31148183 |
2020 |
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Eukaryotic elongation factor 2 kinase promotes angiogenesis in hepatocellular carcinoma via PI3K/Akt and STAT3.
|
31286509 |
2020 |
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
The present study summarizes the major findings about the regulatory role of miRNAs in the PI3K/AKT/mTOR pathway in the pathogenesis of HCC.
|
31663122 |
2020 |
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
The PIK3 CA gene encodes the p110α protein subunit and is one of the most efficient cancer genes in solid and hematological tumors including hepatocellular carcinoma (HCC).
|
31668943 |
2020 |
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
This study aims to investigate the anticancer effect of Oroxin B (OB) both in vitro and in vivo, and the molecular mechanism involved in microRNA-221 and the PI3K/Akt/PTEN pathway through modulation of apoptosis in Hepatocellular carcinoma (HCC).
|
31801250 |
2019 |
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Inhibition of PI3K/mTOR increased the sensitivity of hepatocellular carcinoma cells to cisplatin via interference with mitochondrial-lysosomal crosstalk.
|
31033054 |
2019 |
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
<b>Background:</b> A recent study has revealed that miR-106b-5p might promote hepatocellular carcinoma (HCC) stemness maintenance and metastasis by targeting PTEN via PI3K/Akt pathway based on HCC cell lines and animal models.Its clinical relevance remains unknown.
|
31406464 |
2019 |
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
HCC was recently shown to harbor a distinct genetic make-up and the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kiase (PI3K)/AKT signaling pathways are potential targets for anti-cancer agents in the management of recurrent HCC.
|
31443247 |
2019 |
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
RosA can inhibit the proliferation and invasion of hepatocellular carcinoma cell in vitro and inhibit tumour growth in vivo and the mechanism may relate to inhibiting the activation of PI3K/AKT signal pathway.
|
31541884 |
2019 |
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Further investigations found that TFAP4 promotes invasion and metastasis by inducing epithelial-mesenchymal transition (EMT) and regulating MMP-9 expression via activating the PI3K/AKT signaling pathway in HCC.
|
31281549 |
2019 |
Liver carcinoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Gene set enrichment analysis results revealed a positive correlation between the PI3K pathway and triggering receptors expressed on myeloid cells 2 (TREM2) expression in HCC tissues.
|
30067868 |
2019 |
Liver carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Using PIK3CA(H1047R)/c-Met, PIK3CA(E545K)/c-Met, and sgPten/c-Met murine HCC models, we also demonstrated that deletion of Sgk3 moderately delays PIK3CA(E545K)/c-Met driven HCC, while not affecting PIK3CA(H1047R)/c-Met or sgPten/c-Met HCC formation in mice.
|
30975125 |
2019 |
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Our findings revealed that MCM3 promoted radioresistance through activating NF-κB pathway, strengthening the role of MCM subunits in the tumor progression and providing a new target for HCC therapy.
|
31208444 |
2019 |
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
CD73 promotes progression and metastasis through activating PI3K/AKT signaling, indicating a novel prognostic biomarker for HCC.
|
30971294 |
2019 |
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
PI3K/mTOR inhibition prevented moderate heat stress-induced global effects on HCC molecular signaling and cellular function, including decreased cell survival, growth, and proliferation (Z-score, -0.3 to -3.2; <i>P</i> < .001) and increased apoptosis and cell death (Z-score, 0.4-1.1; <i>P</i> < .001).ConclusionModerate heat stress induces PI3K/mTOR/AKT-dependent global effects on hepatocellular carcinoma (HCC) cell survival, function, and death.
|
31335281 |
2019 |
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Our study reveals a function of Art that induces HCC apoptosis via PI3K/AKT/mTOR pathway inhibition and suggests a potential therapeutic regimen of combination with Art and SOR against advanced HCC.
|
31481232 |
2019 |
Liver carcinoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Our results unveiled that the Columbamine suppression on HCC based on the traditional medicine are clearly associated with PI3K/AKT, p38 and ERK1/2 MAPKs signaling pathways and guide further research orientation for developing the Col medicine against hepatocellular carcinoma.
|
30582951 |
2019 |
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
These data confirmed that the downregulation of MARCH1 could inhibit the progression of hepatocellular carcinoma and that the mechanism may be via PI3K/AKT/β-catenin inactivation as well as the downregulation of the antiapoptotic Mcl-1/Bcl-2.
|
30678274 |
2019 |
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Furthermore, the OB3 peptide inhibited phosphoinositide 3-kinase (PI3K) activation which is essential for leptin-induced proliferation in HCC.
|
31499123 |
2019 |
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
The inhibition of <i>PTEN</i> could reverse the anti-tumor action caused by the knockdown of <i>miR-367</i> <i>MiR-367</i> serves as an oncogene in HCC through activating the PI3K/AKT pathway by targeting <i>PTEN</i>.
|
31541003 |
2019 |
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Furthermore, these findings suggest that the miR-221/AEG-1 axis plays a seminal oncogenic role by modulating PTEN/PI3K/AKT signaling pathway in HCC.
|
31698701 |
2019 |
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
In addition, we observed that KLF5 could promote the epithelial-mesenchymal transition (EMT) in HCC via the PI3K/AKT/Snail signaling pathway.
|
30473218 |
2019 |
Liver carcinoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Phosphatidylinositol 3-kinase (PI3K), on the other hand, has been shown to play a key role in the tumorigenesis, proliferation, metastasis, apoptosis, and angiogenesis of HCC by regulating gene expression.
|
30796964 |
2019 |