|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pyrazolopyrimide library screening in glioma cells discovers highly potent antiproliferative leads that target the PI3K/mTOR pathway.
|
31787462 |
2020 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, we demonstrated a novel cellular mechanism that was dependent of the lncRNA-XIST/miR-126/IRS1/PI3K/Akt pathway in enhanced glucose metabolism in glioma.
|
31680298 |
2020 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
BRCA1-associated protein inhibits glioma cell proliferation and migration and glioma stem cell self-renewal via the TGF-β/PI3K/AKT/mTOR signalling pathway.
|
31776938 |
2020 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sevoflurane downregulates insulin-like growth factor-1 to inhibit cell proliferation, invasion and trigger apoptosis in glioma through the PI3K/AKT signaling pathway.
|
31305291 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among the many possible mechanisms underlying its pathogenesis, hyperactivation of the PI3K/Akt pathway is essential to the occurrence and development of glioma through the loss of PTEN or somatic activating mutations in PIK3CA.
|
30542720 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The goal of this study was therefore to identify magnetic resonance spectroscopy (MRS)-detectable metabolic biomarkers associated with IDHmut glioma response to the dual PI3K/(mTOR) inhibitor XL765.
|
31324855 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, the present study was conducted with aims of exploring the ability of MCL1 silencing to influence glioma cell senescence and apoptosis through the mediation of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway.
|
30296359 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we generated a patient-derived glioma sphere-forming cell (GSC) xenograft model resistant to the PI3K-specific inhibitor BKM-120.
|
31416846 |
2019 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mechanistically, we uncovered that BCAR4 activated PI3K/AKT signaling pathway in glioma through upregulating EGFR and interacting with it.
|
31173355 |
2019 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Bone marrow mesenchymal stem cells suppress growth and promote the apoptosis of glioma U251 cells through downregulation of the PI3K/AKT signaling pathway.
|
30784920 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The down-regulation of MRP1 may be related with the VEGF/PI3K/Akt pathway in glioma.
|
31190861 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, LINC00526/EZH2/AXL/PI3K/Akt/NF-κB form a feedback loop in glioma.
|
31240814 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overexpression of miR-770 indicates a favorable prognosis and suppresses tumorigenesis by modulating PI3K-AKT pathway in glioma.
|
31002138 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Then we discovered that silencing EMP1 inhibited glioma cell invasion and proliferation through inhibiting the PI3K-AKT signaling pathway.
|
31111534 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Temozolomide induces activation of Wnt/β-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy.
|
31758290 |
2019 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, KEGG PathwayFinder by gene correlation analysis was performed on the R2: Genomics Analysis and Visualization Platform, which revealed a high association between Ngb and the phosphatidylinositol 3‑kinase (PI3K)/AKT pathway using glioma data (GSE4290) from the Gene Expression Omnibus database.
|
29207186 |
2018 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our results suggest that LASP1 activates the PI3K/AKT signaling pathway and is downregulated by miR-377-3p during glioma progression.
|
30372896 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CEP55 promotes cell proliferation and inhibits apoptosis via the PI3K/Akt/p21 signaling pathway in human glioma U251 cells.
|
29552118 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MicroRNA-1231 exerts a tumor suppressor role through regulating the EGFR/PI3K/AKT axis in glioma.
|
29774498 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mechanistic investigation showed that LINC01426 exhibited its tumor promoter role by modulating PI3K/Akt signaling pathway in glioma.
|
30338804 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Evodiamine activates cellular apoptosis through suppressing PI3K/AKT and activating MAPK in glioma.
|
29535541 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings present a novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis and that disruption of downstream CREB signaling attenuates tumor expansion.
|
29718345 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Down-regulation of ABCE1 inhibits temozolomide resistance in glioma through the PI3K/Akt/NF-κB signaling pathway.
|
30455394 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
AnnexinA5 promote glioma cell invasion and migration via the PI3K/Akt/NF-κB signaling pathway.
|
29520611 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results illustrate the novel role of T11TS immunotherapy in ameliorating the PI3K pathway in T-cells in glioma-bearing animals to enhance T-cell survival, according greater defense against glioma.
|
28608562 |
2018 |