Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest that LncRNA LOXL1-AS1 promoted the proliferation and metastasis of medulloblastoma by activating the PI3K-AKT pathway, providing evidence that knockdown of LncRNA LOXL1-AS1 might be a potential therapeutic strategy against medulloblastoma.
|
30050750 |
2018 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this context, we demonstrate that the clinically available PI3K inhibitor GDC-0941 enhances the anti-neoplastic efficacy of Axitinib against c-myc-amplified medulloblastoma.
|
29377550 |
2018 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The data from the present study suggest that TRIM59 induces epithelial-to-mesenchymal transition and promotes migration and invasion by PI3K/AKT signaling pathway in medulloblastoma.
|
29805559 |
2018 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, we investigated the anti-MB efficacies of combined HH inhibitor Vismodegib and PI3K-mTOR dual-inhibitor BEZ235 together or combined individually with cisplatin against high-risk MB.
|
29682173 |
2018 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings therefore provide a rational to further evaluate Vandetanib in combination with PI3K inhibitors as well as standard chemotherapeutics in vivo for the treatment of most aggressive medulloblastoma variants.
|
28159923 |
2017 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Targeting the PI3K/AKT/mTOR signaling pathway in medulloblastoma.
|
25601471 |
2015 |
Adult Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The impact of RNA interference (RNAi)-mediated silencing of PI3K isoforms p110α and p110δ on global gene expression was investigated by DNA microarray analysis in medulloblastoma cell lines.
|
25915540 |
2015 |
Adult Medulloblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The mitogen-activated protein kinase (MAPK) pathway, but not the phosphoinositide 3-kinase (PI3K)-Akt pathway, was downregulated in medulloblastoma cells, whereas the PI3K-Akt pathway, but not the MAPK pathway, was downregulated in glioblastoma cells.
|
24584142 |
2014 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
A pharmacological inhibitor of p110γ (encoded by PIK3CG) impaired cell proliferation in medulloblastoma cell lines and sensitized the cells to cisplatin treatment.
|
21652733 |
2011 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
A pharmacological inhibitor of p110γ (encoded by PIK3CG) impaired cell proliferation in medulloblastoma cell lines and sensitized the cells to cisplatin treatment.
|
21652733 |
2011 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
PI3K pathway regulates survival of cancer stem cells residing in the perivascular niche following radiation in medulloblastoma in vivo.
|
18281460 |
2008 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
To examine a role for PI3K/AKT signaling in the molecular pathogenesis of human medulloblastoma, we did an immunohistochemical study of the expression of Ser473-phosphorylated (p)-AKT protein in 22 medulloblastoma samples: All samples displayed p-AKT expression.
|
16707597 |
2006 |
Adult Medulloblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Small-molecule inhibitors of the Shh/Patched and PI3K pathways are potential chemotherapeutic agents for patients with medulloblastoma.
|
16398471 |
2005 |