PLAT, plasminogen activator, tissue type, 5327

N. diseases: 392; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental
0.500 Biomarker disease CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136 2014
CUI: C2937358
Disease: Cerebral Hemorrhage
Cerebral Hemorrhage
0.500 Biomarker phenotype CTD_human Reduced estimated glomerular filtration rate is associated with stroke outcome after intravenous rt-PA: the Stroke Acute Management with Urgent Risk-Factor Assessment and Improvement (SAMURAI) rt-PA registry. 21088392 2011
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental
0.500 Biomarker disease RGD Fraxinus rhynchophylla ethanol extract attenuates carbon tetrachloride-induced liver fibrosis in rats via down-regulating the expressions of uPA, MMP-2, MMP-9 and TIMP-1. 20035854 2010
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Therapeutic disease CTD_human Neurological picture. Orolingual angio-oedema after alteplase therapy in a stroke patient concurrently using angiotensin II receptor blocker. 20547619 2010
CUI: C2937358
Disease: Cerebral Hemorrhage
Cerebral Hemorrhage
0.500 Biomarker phenotype CTD_human Symptomatic intracerebral hemorrhage among eligible warfarin-treated patients receiving intravenous tissue plasminogen activator for acute ischemic stroke. 20212195 2010
CUI: C2937358
Disease: Cerebral Hemorrhage
Cerebral Hemorrhage
0.500 Biomarker phenotype CTD_human Edaravone, a free radical scavenger, inhibits MMP-9-related brain hemorrhage in rats treated with tissue plasminogen activator. 19095969 2009
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Therapeutic disease CTD_human [Orolingual angioedema as complication after rt-PA in stroke patient treated with ACE inhibitor]. 18453163 2008
CUI: C2937358
Disease: Cerebral Hemorrhage
Cerebral Hemorrhage
0.500 Biomarker phenotype CTD_human Symptomatic intracerebral hemorrhage and recanalization after IV rt-PA: a multicenter study. 18753474 2008
CUI: C2937358
Disease: Cerebral Hemorrhage
Cerebral Hemorrhage
0.500 Biomarker phenotype CTD_human NXY-059 for the treatment of acute stroke: pooled analysis of the SAINT I and II Trials. 18369171 2008
CUI: C2937358
Disease: Cerebral Hemorrhage
Cerebral Hemorrhage
0.500 Biomarker phenotype CTD_human Intravenous recombinant tissue plasminogen activator improves arterial recanalization rates and reduces infarct volumes in patients with hyperdense artery sign on baseline computed tomography. 18346647 2008
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Therapeutic disease CTD_human Assessment of suitability of thrombolysis in middle cerebral artery infarction: a proof of concept study of a stereologically-based technique. 17690543 2007
CUI: C2937358
Disease: Cerebral Hemorrhage
Cerebral Hemorrhage
0.500 Biomarker phenotype CTD_human Assessment of suitability of thrombolysis in middle cerebral artery infarction: a proof of concept study of a stereologically-based technique. 17690543 2007
CUI: C2937358
Disease: Cerebral Hemorrhage
Cerebral Hemorrhage
0.500 Biomarker phenotype CTD_human Argatroban tPA stroke study: study design and results in the first treated cohort. 16908730 2006
CUI: C2937358
Disease: Cerebral Hemorrhage
Cerebral Hemorrhage
0.500 Biomarker phenotype CTD_human Recombinant tissue plasminogen activator for minor strokes: the National Institute of Neurological Disorders and Stroke rt-PA Stroke Study experience. 16126134 2005
CUI: C2937358
Disease: Cerebral Hemorrhage
Cerebral Hemorrhage
0.500 Biomarker phenotype CTD_human Our findings suggest that endogenous tPA plays an important role in heparin-produced cerebral hemorrhage via MMP9 induction and activation. 16190367 2005
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury
0.500 Biomarker disease RGD Reductions in mRNA of the neuroprotective agent, neuroserpin, after cerebral ischemia/reperfusion in diabetic rats. 15223382 2004
CUI: C2937358
Disease: Cerebral Hemorrhage
Cerebral Hemorrhage
0.500 Biomarker phenotype CTD_human Essential role of endogenous tissue plasminogen activator through matrix metalloproteinase 9 induction and expression on heparin-produced cerebral hemorrhage after cerebral ischemia in mice. 14630814 2004
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Biomarker disease RGD Temporal profile of tissue plasminogen activator (tPA) and inhibitor expression after transient focal cerebral ischemia. 14512838 2003
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery
0.500 Therapeutic disease CTD_human Arterial reocclusion in stroke patients treated with intravenous tissue plasminogen activator. 12297567 2002
CUI: C2937358
Disease: Cerebral Hemorrhage
Cerebral Hemorrhage
0.500 Therapeutic phenotype RGD Tissue plasminogen activator for the treatment of intraventricular hematoma: the dose-effect relationship. 12220690 2002
CUI: C2937358
Disease: Cerebral Hemorrhage
Cerebral Hemorrhage
0.500 Biomarker phenotype CTD_human Markers of increased risk of intracerebral hemorrhage after intravenous recombinant tissue plasminogen activator therapy for acute ischemic stroke in clinical practice: the Multicenter rt-PA Stroke Survey. 11940547 2002
CUI: C2937358
Disease: Cerebral Hemorrhage
Cerebral Hemorrhage
0.500 Biomarker phenotype CTD_human Early stroke treatment associated with better outcome: the NINDS rt-PA stroke study. 11113218 2000
CUI: C2937358
Disease: Cerebral Hemorrhage
Cerebral Hemorrhage
0.500 Biomarker phenotype CTD_human Brain hemorrhages after rt-PA treatment of embolic stroke in spontaneously hypertensive rats. 10501537 1999
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury
0.500 Therapeutic disease CTD_human tPA-associated reperfusion after acute stroke demonstrated by SPECT. 9472885 1998
CUI: C2937358
Disease: Cerebral Hemorrhage
Cerebral Hemorrhage
0.500 Biomarker phenotype CTD_human Thrombolysis with intravenous rtPA in a series of 100 cases of acute carotid territory stroke: determination of etiological, topographic, and radiological outcome factors. 9836764 1998