PLAU, plasminogen activator, urokinase, 5328

N. diseases: 439; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.390 AlteredExpression group BEFREE The expressions of uPA and p38MAPK proteins were significantly higher in esophageal squamous cell carcinoma or adenocarcinoma than in normal esophageal mucosa tissue (both <i>P</i><0.0001). 30568465 2018
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.390 Biomarker group BEFREE Finally, expression of miR-193a is inversely correlated with PLAU and K-Ras in human colon adenocarcinomas. 21670079 2011
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.390 Biomarker group BEFREE In this study, we analyzed the role of the uPAR/uPA system in both the development and progression of pancreatic cancer in invasive ductal adenocarcinomas of the pancreas (PDA) and their premalignant precursors (PanIN lesions) in 50 patients with long-term clinical follow-up. 19435784 2009
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.390 AlteredExpression group BEFREE We examined mRNA expression of the urokinase-type plasminogen activator (uPA), its receptor (uPAR), and the plasminogen activator inhibitor 1 (PAI-1) in a panel of adenocarcinomas of the pancreas (PC) and cancers of the papilla of Vater (CPV). 18376309 2008
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.390 AlteredExpression group LHGDN Prognostic significance of growth factors and the urokinase-type plasminogen activator system in pancreatic ductal adenocarcinoma. 18376307 2008
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.390 AlteredExpression group LHGDN We have studied the expression of urokinase-type plasminogen activator (uPA) mRNA, uPA receptor (uPAR) mRNA and immunoreactivity, and type-1 plasminogen activator inhibitor (PAI-1) mRNA and immunoreactivity in 16 prostate adenocarcinomas and 9 benign prostate hyperplasias. uPA mRNA and uPAR mRNA expression were found in 9 and 8 of the adenocarcinomas, respectively, and in 7 and 6 of the benign hyperplasias, respectively. 15515049 2005
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.390 AlteredExpression group BEFREE We have studied the expression of urokinase-type plasminogen activator (uPA) mRNA, uPA receptor (uPAR) mRNA and immunoreactivity, and type-1 plasminogen activator inhibitor (PAI-1) mRNA and immunoreactivity in 16 prostate adenocarcinomas and 9 benign prostate hyperplasias. uPA mRNA and uPAR mRNA expression were found in 9 and 8 of the adenocarcinomas, respectively, and in 7 and 6 of the benign hyperplasias, respectively. 15515049 2005
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.390 Biomarker group CTD_human Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA. 10467400 1999
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.390 Biomarker group BEFREE Using in situ hybridization to analyze the coexpression of laminin-5 and components of the plasminogen activation system, we found that the histological distribution of laminin-5-positive budding cancer cells at the invasion front in colon adenocarcinomas was identical to that of the receptor for urokinase-type plasminogen activator. 7664291 1995
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.390 AlteredExpression group BEFREE The inhibitory effects of amiloride on uPA gene expression reported in this paper may offer the prospect of developing new therapeutic approaches to the prevention of invasion and metastasis by adenocarcinomas. 7750207 1995
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.390 AlteredExpression group BEFREE Urokinase-type plasminogen activator is expressed in stromal cells and its receptor in cancer cells at invasive foci in human colon adenocarcinomas. 1850957 1991