|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of current study was to provide a proof-of-concept on the mechanism of PLAU and PCDH10 gene expressions and caspases-3, -8, and -9 activities in the apoptotic pathway after treatment of malignant human glioma cell line (U87MG) with cytochalasin H.
|
30507090 |
2019 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Furthermore, key components (i.e., uPAR, uPA, and pro-MMP-2) were contributed principally by astrocytes, whereas the U251N glioma cells provided plasminogen.
|
12764090 |
2003 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results support the therapeutic potential of targeting the individual components of the uPAR-uPA system by using a single adenovirus construct for the treatment of glioma and other invasive cancers.
|
12955075 |
2003 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our previous studies showed that the urokinase-type plasminogen activator receptor (uPAR) and the p16 tumor suppressor gene play a significant role in glioma invasion.
|
11791179 |
2002 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The fibrinolytic activities of conditioned medium and cell lysates from human glioma cell lines, A172, T98G, U87 and TM1 were studied by fibrin plate zymography. mRNA expression of tissue plasminogen activator (tPA), urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitors (PAI-1, PAI-2) was measured by Northern blot analysis.
|
12241114 |
2002 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results suggested that down-regulation of uPA expression may be a feasible approach to reducing the malignancy and invasiveness of glial tumors.
|
11489835 |
2001 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using human uPA promoter chloramphenicol acetyl transferase (CAT) constructs with mutations of the AP-1 element at -1967 or the PEA-3 cis element at -1973, the activity of the uPA promoter was decreased 4-fold to 10-fold in all three human glioma cell lines.
|
11115541 |
2001 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of uPA is associated with the malignant progression, invasion and angiogenesis of gliomas, and it may play a critical role in the recurrence and prognosis of gliomas.
|
11776074 |
2000 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Adenovirus-mediated delivery of antisense gene to urokinase-type plasminogen activator receptor suppresses glioma invasion and tumor growth.
|
10416596 |
1999 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our previous studies showed that glioblastomas express increased urokinase-type plasminogen activator receptors (uPARs) in comparison to low-grade gliomas (Yamamoto et al., Cancer Res., 54, 5016-5020, 1994).
|
9219733 |
1997 |