Hypoplasminogenemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Plasmin generation was able to be detected in only one (23% plasminogen activity) of the five PLGD patients.
|
31469483 |
2019 |
Hypoplasminogenemia
|
0.700 |
Biomarker
|
disease |
CLINGEN |
An open-label phase 2/3 study of human Glu-plasminogen administered IV at 6.6 mg/kg every 2 to 4 days in 15 patients with congenital plasminogen deficiency is ongoing.
|
29321155 |
2018 |
Hypoplasminogenemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
An open-label phase 2/3 study of human Glu-plasminogen administered IV at 6.6 mg/kg every 2 to 4 days in 15 patients with congenital plasminogen deficiency is ongoing.
|
29321155 |
2018 |
Hypoplasminogenemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Mice with a combined deficiency in FVIII and plasminogen displayed no phenotypic differences relative to mice with single FVIII or plasminogen deficiency.
|
30459211 |
2018 |
Hypoplasminogenemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Although fibrinogen-deficient mice or mice with combined deficiencies of plasminogen and fibrinogen had decreased EAE severity, they did not exhibit the delay in EAE disease onset, as seen in mice with plasminogen deficiency alone.
|
28275164 |
2017 |
Hypoplasminogenemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Although plasminogen is a key protein in fibrinolysis and several mutations in the plasminogen gene (PLG) have been identified that result in plasminogen deficiency, there are conflicting reports to associate it with the risk of thrombosis.
|
27976734 |
2016 |
Hypoplasminogenemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The connection between plasmin-dependent fibrinolysis, vascular patency, and tumor growth was further substantiated as the effect of plasminogen deficiency on tumor growth could be reverted by superimposing heterozygous fibrinogen deficiency on Plg(-/-) mice.
|
22815383 |
2012 |
Hypoplasminogenemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
One healthy individual with homozygous plg gene polymorphism 504W studied so far exhibited low normal plg antigen and slightly decreased plg activity, suggesting that this polymorphism is associated with (mild) hypoplasminogenemia.
|
21537161 |
2011 |
Hypoplasminogenemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, while plasminogen deficiency was initially believed to be related to development of venous thromboembolic disease, more recent data suggest that decreased plasminogen levels may not, in and of themselves, increase the risk of thrombosis.
|
19141167 |
2008 |
Hypoplasminogenemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Plasminogen (plg) deficiency has been classified as (i) hypoplasminogenemia or 'true' type I plg deficiency, and (ii) dysplasminogenemia, also called type II plg deficiency.
|
17900274 |
2007 |
Hypoplasminogenemia
|
0.700 |
GermlineCausalMutation
|
disease |
ORPHANET |
Molecular and clinical spectrum of type I plasminogen deficiency: A series of 50 patients.
|
16849641 |
2006 |
Hypoplasminogenemia
|
0.700 |
Biomarker
|
disease |
CLINGEN |
Molecular and clinical spectrum of type I plasminogen deficiency: A series of 50 patients.
|
16849641 |
2006 |
Hypoplasminogenemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Three patients with severe hypoplasminogenemia and different plg gene mutations exhibited characteristic "abnormal" IEF band patterns when compared with IEF plg phenotypes A and B.
|
15269832 |
2004 |
Hypoplasminogenemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We present a patient with ligneous inflammation of her genital, middle ear, and oral mucosa that was associated with type-1 homozygous plasminogen deficiency due to a novel missense mutation in the plasminogen gene.
|
15213608 |
2004 |
Hypoplasminogenemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the K19E mutation in the plasminogen gene is a common cause of hypoplasminogenaemia in Scotland, with an estimated prevalence of around 0.14%.
|
12945885 |
2003 |
Hypoplasminogenemia
|
0.700 |
Biomarker
|
disease |
CLINGEN |
Pulmonary involvement in a child with ligneous conjunctivitis and homozygous type I plasminogen deficiency.
|
11477736 |
2001 |
Hypoplasminogenemia
|
0.700 |
Biomarker
|
disease |
CLINGEN |
Compound-heterozygous mutations in the plasminogen gene predispose to the development of ligneous conjunctivitis.
|
10233898 |
1999 |
Hypoplasminogenemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Furthermore, we found combinations of antithrombin deficiency/elevated Lp(a), hyperhomocysteinemia/Lp(a), deficiency of HCII/plasminogen, and plasminogen deficiency along with increased Lp(a) each in one.
|
10650845 |
1999 |
Hypoplasminogenemia
|
0.700 |
Biomarker
|
disease |
CLINGEN |
Extrahepatic synthesis of plasminogen in the human cornea is up-regulated by interleukins-1alpha and -1beta.
|
10215610 |
1999 |
Hypoplasminogenemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
This study provides direct evidence that plasminogen deficiency is one cause of ligneous conjunctivitis and suggests that plasminogen-deficient mice may be an excellent model for the development of therapeutic strategies for the treatment of this debilitating disease.
|
9473227 |
1998 |
Hypoplasminogenemia
|
0.700 |
Biomarker
|
disease |
CLINGEN |
Ligneous conjunctivitis in plasminogen-deficient mice.
|
9473227 |
1998 |
Hypoplasminogenemia
|
0.700 |
Biomarker
|
disease |
CLINGEN |
Therapy with a purified plasminogen concentrate in an infant with ligneous conjunctivitis and homozygous plasminogen deficiency.
|
9834305 |
1998 |
Hypoplasminogenemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The proposita of family B, referred for superficial thrombophlebitis, had low plasminogen levels (activity 55% and antigen 53%) and APC resistance (APC-SR = 1.5) whereas the asymptomatic mother and the brother had isolated APC resistance (APC-SR = 1.62 and 1.8, respectively) and the asymptomatic father isolated plasminogen deficiency (activity 61% and antigen 62%).
|
9544982 |
1998 |
Hypoplasminogenemia
|
0.700 |
Biomarker
|
disease |
CLINGEN |
Healing of corneal epithelial defects in plasminogen- and fibrinogen-deficient mice.
|
9501859 |
1998 |
Hypoplasminogenemia
|
0.700 |
Biomarker
|
disease |
CLINGEN |
Ala601-Thr type dysplasminogenaemia genetically diagnosed in patients with retinochoroidal vascular disorders.
|
9375744 |
1997 |