ACTH Syndrome, Ectopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
De-differentiation may therefore explain the mechanism underlying the negative correlation between immunoreactivity for ACTH in EAS and disease aggressiveness.
|
30918166 |
2019 |
ACTH Syndrome, Ectopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This is the first case of ectopic ACTH syndrome associated with an ONB that acquired the ability to express ACTH during its clinical course as shown by serial immunohistochemical examinations.
|
30392451 |
2018 |
ACTH Syndrome, Ectopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Spontaneous adrenocorticotropic hormone (ACTH) normalisation due to tumour regression induced by metyrapone in a patient with ectopic ACTH syndrome: case report and literature review.
|
29587720 |
2018 |
ACTH Syndrome, Ectopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data suggested a possibility that SCLC secreted ACTH and caused EAS in this patient.
|
30232300 |
2018 |
ACTH Syndrome, Ectopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
The review finishes with a cautionary note with regard to the misdiagnosis of the ectopic ACTH syndrome in which partial processing of ACTH can result in large concentrations of α-MSH and CLIP, which can interfere in the performance of two-site immunoassays, and the problem of the correct disulphide bridge arrangement in synthetic N-POMC peptides is also discussed.
|
26643914 |
2016 |
ACTH Syndrome, Ectopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
To determine the effects of GR expression in vivo, we characterized a mouse SCLC xenograft model that secretes ACTH precursor peptides, and so drives high circulating corticosterone concentrations (analogous to the ectopic ACTH syndrome).
|
20015838 |
2010 |
ACTH Syndrome, Ectopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
ACTH-dependent Cushing's syndrome is due to ACTH overproduction originating from a pituitary corticotroph adenoma (Cushing's disease) or from ectopic tumors (ectopic ACTH syndrome).
|
18075284 |
2007 |
ACTH Syndrome, Ectopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
ACTH is frequently produced in non-pituitary tumours, leading to the ectopic-ACTH syndrome, but the molecular mechanisms of its expression remain obscure.
|
16382005 |
2006 |
ACTH Syndrome, Ectopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
It is concluded that hypomethylation of the POMC promoter in thymic carcinoids correlates with POMC overexpression and the ectopic ACTH syndrome.
|
15845926 |
2005 |
ACTH Syndrome, Ectopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Pro-opiomelanocortin expression in a metastatic breast carcinoma with ectopic ACTH secretion.
|
15239795 |
2005 |
ACTH Syndrome, Ectopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Following desmopressin administration there was an overlap of the percent F and ACTH responses among patients with CD and EAS, and the area under the ROC curve for both these responses was not significantly different than that occurring by chance.
|
11932296 |
2002 |
ACTH Syndrome, Ectopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This report suggests that lymphocytes in thymic hyperplasia are the most likely site of deregulated ACTH expression causing ectopic ACTH syndrome.
|
11075732 |
2000 |
ACTH Syndrome, Ectopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently it was shown that patients with pituitary corticotrope adenomas respond to GHS with a dramatic rise in ACTH secretion, and it has been suggested that GHS may provide a diagnostic tool to differentiate Cushing's disease from the ectopic ACTH syndrome.
|
9437242 |
1997 |
ACTH Syndrome, Ectopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, the DDAVP stimulation test, i.e., determination of plasma ACTH levels after 5 microg DDAVP injection, seems useful for discriminating Cushing's disease from normality, and may serve to facilitate the differentiation between Cushing's disease and ectopic ACTH syndrome.
|
9466324 |
1997 |
ACTH Syndrome, Ectopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Altogether, our results provide evidence that DMS-79 is a valid model of tumors responsible for the ectopic ACTH syndrome and that the mechanism of POMC gene expression in these SCLC cells is different from that in pituitary cells.
|
8800643 |
1995 |
ACTH Syndrome, Ectopic
|
0.400 |
Biomarker
|
disease |
CTD_human |
Colonic adenocarcinoma associated ectopic ACTH secretion: a case history.
|
8562174 |
1995 |
ACTH Syndrome, Ectopic
|
0.400 |
Biomarker
|
disease |
BEFREE |
In studying the peptides secreted by the extra-pituitary tumours responsible for the ectopic ACTH syndrome it would appear that direct measurement of ACTH precursors and comparison with the circulating concentrations of ACTH can give valuable information on the percentage of tumours which do not effectively process the ACTH precursors.
|
8396510 |
1993 |
ACTH Syndrome, Ectopic
|
0.400 |
Biomarker
|
disease |
CTD_human |
Ectopic ACTH-producing adenocarcinoma of the stomach.
|
1459535 |
1992 |
ACTH Syndrome, Ectopic
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We studied the mechanism of POMC gene expression in human nonpituitary tumors that is responsible for the ectopic ACTH syndrome.
|
2536890 |
1989 |
ACTH Syndrome, Ectopic
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Immunoreactive (IR) POMC peptides have been detected in several human nonpituitary tissues and most pheochromocytomas and lung cancers, including those not associated with ectopic ACTH syndrome.
|
2845257 |
1988 |
ACTH Syndrome, Ectopic
|
0.400 |
Biomarker
|
disease |
CTD_human |
Ectopic ACTH syndrome due to Grawitz tumor.
|
2844640 |
1988 |
ACTH Syndrome, Ectopic
|
0.400 |
Biomarker
|
disease |
CTD_human |
Cushing's syndrome secondary to ACTH-secreting Wilms' tumor.
|
4367732 |
1974 |