PON1, paraoxonase 1, 5444

N. diseases: 496; N. variants: 29
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.340 GeneticVariation disease BEFREE The current study aims to examine superoxide dismutase (SOD1), catalase, lipid hydroperoxides (LOOH), nitric oxide metabolites (NOx), advanced oxidation protein products (AOPP), malondialdehyde (MDA), glutathione (GSH), paraoxonase 1 (PON1), high-density lipoprotein cholesterol (HDL), and uric acid (UA) in participants with and without generalized anxiety disorder (GAD) co-occurring or not with BD, MDD, or tobacco use disorder. 29736827 2018
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.340 Biomarker disease BEFREE The association between paraoxonase 1 (PON1), an important antioxidant enzyme, and development of BD has been scarcely investigated. 25600537 2015
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.340 Biomarker disease PSYGENET We thus attempted to examine genetic variants in the PON1 gene, a putative BD susceptibility gene, in patients with bipolar disease and their first-degree relatives. 25600537 2015
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.340 Biomarker disease PSYGENET The results suggest that lowered plasma PON1 activity is a trait marker of major depression and that PONQ192R gene-environment (smoking) interactions differentially predict the odds of depression and bipolar disorder. 24679385 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.340 GeneticVariation disease BEFREE Aims and methods This study aimed to delineate the associations of the MetS with plasma PON1 activity, PON1 Q192R genotypes, smoking, and mood disorders (major depression and bipolar disorder), while adjusting for HDL cholesterol, body mass index, age, gender, and sociodemographic data. 25037113 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.340 AlteredExpression disease BEFREE The results suggest that lowered plasma PON1 activity is a trait marker of major depression and that PONQ192R gene-environment (smoking) interactions differentially predict the odds of depression and bipolar disorder. 24679385 2014
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder
0.340 Biomarker disease PSYGENET Aims and methods This study aimed to delineate the associations of the MetS with plasma PON1 activity, PON1 Q192R genotypes, smoking, and mood disorders (major depression and bipolar disorder), while adjusting for HDL cholesterol, body mass index, age, gender, and sociodemographic data. 25037113 2014