Amyotrophic Lateral Sclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
PON1 is a disease modifier gene in amyotrophic lateral sclerosis: association of the Q192R polymorphism with bulbar onset and reduced survival.
|
30903418 |
2019 |
Amyotrophic Lateral Sclerosis
|
0.700 |
Biomarker
|
disease |
CTD_human |
In addition, polymorphisms in paraoxonase 1, an enzyme that detoxifies OPs, may increase individual vulnerability both to OP poisoning and to the risk of developing ALS.
|
28070599 |
2017 |
Amyotrophic Lateral Sclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In addition, polymorphisms in paraoxonase 1, an enzyme that detoxifies OPs, may increase individual vulnerability both to OP poisoning and to the risk of developing ALS.
|
28070599 |
2017 |
Amyotrophic Lateral Sclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis showed lack of associations between PON1 Q192R and L55M polymorphisms and susceptibility to ALS in the European population.
|
25301263 |
2015 |
Amyotrophic Lateral Sclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
No links between PON1 polymorphisms or activity have been found in other neurodegenerative diseases such as multiple sclerosis and amyotrophic lateral sclerosis.
|
24225313 |
2014 |
Amyotrophic Lateral Sclerosis
|
0.700 |
GermlineCausalMutation
|
disease |
ORPHANET |
Genetics of amyotrophic lateral sclerosis: an update.
|
23941283 |
2013 |
Amyotrophic Lateral Sclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Paraoxonase (PON) gene polymorphisms have been associated with susceptibility to sporadic amyotrophic lateral sclerosis (ALS).
|
20381198 |
2011 |
Amyotrophic Lateral Sclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Recent reports describe a genetic association between the PON genes and sporadic amyotrophic lateral sclerosis (ALS).
|
20582942 |
2010 |
Amyotrophic Lateral Sclerosis
|
0.700 |
GermlineCausalMutation
|
disease |
ORPHANET |
We now report that in genomic DNA from individuals with familial and sporadic ALS, we have identified at least 7 PON gene mutations that are predicted to alter PON function.
|
20582942 |
2010 |
Amyotrophic Lateral Sclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Interaction between PON1 and population density in amyotrophic lateral sclerosis.
|
19104460 |
2009 |
Amyotrophic Lateral Sclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In contrast to previous positive smaller studies, our genetic meta-analysis showed no significant association of amyotrophic lateral sclerosis (ALS) with the PON locus.
|
19321847 |
2009 |
Amyotrophic Lateral Sclerosis
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Interaction between PON1 and population density in amyotrophic lateral sclerosis.
|
19104460 |
2009 |
Amyotrophic Lateral Sclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The possibility that organophosphorus (OP) compounds contribute to motor neuron disease (MND) is supported by association of paraoxonase 1 polymorphisms with amyotrophic lateral sclerosis (ALS) and the occurrence of MND in OP compound-induced delayed neuropathy (OPIDN), in which neuropathy target esterase (NTE) is inhibited by organophosphorylation.
|
18313024 |
2008 |
Amyotrophic Lateral Sclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We conclude that a common haplotype within the PON1 promoter region is associated with susceptibility to sporadic ALS.
|
18618303 |
2008 |
Amyotrophic Lateral Sclerosis
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
We conclude that a common haplotype within the PON1 promoter region is associated with susceptibility to sporadic ALS.
|
18618303 |
2008 |
Amyotrophic Lateral Sclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In addition, PON variants were shown to be associated with susceptibility to ALS in several North American and European populations.
|
18695162 |
2008 |
Amyotrophic Lateral Sclerosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Contrary to expectations, PON1 protein, paraoxonase, diazoxonase, and arylesterase activities were not reduced in amyotrophic lateral sclerosis (ALS).
|
18347314 |
2008 |
Amyotrophic Lateral Sclerosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A gene-environment study of the paraoxonase 1 gene and pesticides in amyotrophic lateral sclerosis.
|
17204329 |
2007 |
Amyotrophic Lateral Sclerosis
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
A gene-environment study of the paraoxonase 1 gene and pesticides in amyotrophic lateral sclerosis.
|
17204329 |
2007 |
Amyotrophic Lateral Sclerosis
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
Hyperlipoproteinemias
|
0.500 |
Biomarker
|
disease |
CTD_human |
Effect of short term treatment with simvastatin and atorvastatin on lipids and paraoxonase activity in patients with hyperlipoproteinaemia.
|
15324535 |
2004 |
Hyperlipoproteinemias
|
0.500 |
Biomarker
|
disease |
RGD |
Dietary fat modulates serum paraoxonase 1 activity in rats.
|
11015468 |
2000 |
Depressive disorder
|
0.470 |
Biomarker
|
disease |
BEFREE |
Genetic polymorphisms of 4 genes, methylenetetrahydrofolate reductase (MTHFR) and apolipoprotein E (ApoE) have been demonstrated to associate with the increased risk for both MDD and stroke, while the association between identified polymorphisms in angiotensin converting enzyme (ACE) and serum paraoxonase (PON1) with depression is still under debate, for the existing studies are insufficient in sample size.
|
30898617 |
2019 |
Depressive disorder
|
0.470 |
GeneticVariation
|
disease |
BEFREE |
Lowered PON1 activities are strongly associated with depression and bipolar disorder, recurrence of (hypo)mania and depression, increased disability and lowered quality of life.
|
28441923 |
2019 |
Depressive disorder
|
0.470 |
Biomarker
|
disease |
BEFREE |
Changes in the concentration levels of GR, IL-18, PON-1, and OxLDL may constitute a biological response to oxidative stress typical of depression.
|
28623707 |
2017 |