Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, we demonstrate that ATRX structural alterations are not loss-of-function and put forward EZH2 inhibitors as a potential therapy for ATRX IFF neuroblastoma.
|
31631027 |
2019 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Variations in SMARCA4 and ATRX occurred more frequently in the NB as compared to the gnomAD control cohort (OR = 4.49, 95%CI: 1.63-9.97, p = 0.038; OR 3.44, 95%CI: 1.46-6.91, p = 0.043, respectively).
|
31018240 |
2019 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, relaying on negative immunohistochemistry for ATRX protein to identify ALT in neuroblastoma may miss a significant proportion of patients.
|
31290759 |
2019 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this mini-review, we will discuss the research progress of TERT-mediated and ATRX-mediated telomere maintenance and NB, especially high-risk tumors.
|
28452859 |
2018 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, anaplastic lymphoma kinase (<i>ALK</i>) mutation and amplification, ALK protein expression, loss of the nuclear alpha thalassemia/mental retardation syndrome X-linked (ATRX) protein, and telomerase reverse transcriptase (TERT) protein expressionwere studied to investigate potential correlations between these molecular characteristics and clinical features or outcomes in neuroblastoma.
|
28546523 |
2018 |
Neuroblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These rearrangements occurred only in high-risk neuroblastomas (12/39, 31%) in a mutually exclusive fashion with MYCN amplifications and ATRX mutations, which are known genetic events in this tumour type.
|
26466568 |
2015 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
TERT rearrangements (23%), ATRX deletions (11%) and MYCN amplifications (37%) identify three almost non-overlapping groups of high-stage neuroblastoma, each associated with very poor prognosis.
|
26523776 |
2015 |
Neuroblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We further evaluate performance on 222 neuroblastoma samples with matched normals and focus on a well-studied rare somatic CNV within the ATRX gene.
|
25618849 |
2015 |
Neuroblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study, alterations of ATRX or DAXX, which both encode chromatin remodeling proteins in telomeric region, and their relationship to ALT were examined in NBLs.
|
25487495 |
2014 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
The genetic landscape of high-risk neuroblastoma.
|
23334666 |
2013 |
Neuroblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Whole genome sequencing of the index liver metastasis identified 44 non-synonymous somatic mutations in 42 genes (0.85 mutation/MB) and a large hemizygous deletion in the ATRX gene which has been recently reported in neuroblastoma.
|
24147068 |
2013 |
Neuroblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, ATRX, TIAM1 and a series of regulators of the Rac/Rho pathway were mutated, further implicating defects in neuritogenesis in neuroblastoma.
|
22367537 |
2012 |