Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
Fenofibrate, a third-generation fibric acid derivative, is an activator of PPARα indicated for the treatment of mixed dyslipidemia and hypertriglyceridemia in adults.
|
30970278 |
2019 |
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
Synthetic PPAR ligands are widely used in the treatment of dyslipidemia (e.g. fibrates - PPARα activators) or in diabetes mellitus (e.g. thiazolidinediones - PPARγ agonists) while a new generation of dual agonists reveals hypolipemic, hypotensive, antiatherogenic, anti-inflammatory and anticoagulant action.
|
31161987 |
2019 |
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
Pemafibrate, due to its high selectivity, is likely to replace other PPARα agonists for dyslipidemia and cardiovascular diseases.
|
31614690 |
2019 |
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
Peroxisome proliferator-activated receptor α (PPARα) is a nuclear hormone receptor that transcriptionally regulates lipid metabolism and inflammation; therefore, PPARα agonists are promising agents to treat dyslipidemia and metabolic disorders.
|
30648583 |
2019 |
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
These observations raise the possibility that 1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid derivatives might be effective drug candidates for selective targeting of PPARα to manage dyslipidemia.
|
29764933 |
2018 |
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
The selective peroxisome proliferator-activated receptor alpha modulator (SPPARM-α), pemafibrate, will be used to target residual cardiovascular risk remaining after treatment to reduce low-density lipoprotein cholesterol (LDL-C) in individuals with the dyslipidemia of type 2 diabetes mellitus (T2).
|
30342298 |
2018 |
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
The compound 13m also increased the expression of genes involved in reverse cholesterol transport (RCT) such as PPARα and LXR1α indicating another mechanism by which compound 13m ameliorates dyslipidemia in Syrian Golden hamster model.
|
29153558 |
2018 |
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
Peroxisome proliferator activated receptor α (PPARα), a drug target for dyslipidemia, is known to be downregulated in cardiomyocytes in response to hypertrophic stimuli.
|
30138942 |
2018 |
Dyslipidemias
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Furthermore, MG clearly alleviated serum TG and total cholesterol release; upregulated AKT, AMPK, and PPARα expression; suppressed SREBP-1c generation; and alleviated hepatic steatosis and dyslipidemia in Ty-induced hyperlipidemia mice.
|
29467759 |
2018 |
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
Preclinical evaluation of saroglitazar magnesium, a dual PPAR-α/γ agonist for treatment of dyslipidemia and metabolic disorders.
|
29224415 |
2018 |
Dyslipidemias
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Typically, PPARα is activated by fibrates, which are commonly used therapeutic agents in the treatment of dyslipidemia.
|
30060458 |
2018 |
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
Efficacy and safety of K-877, a novel selective peroxisome proliferator-activated receptor α modulator (SPPARMα), in combination with statin treatment: Two randomised, double-blind, placebo-controlled clinical trials in patients with dyslipidaemia.
|
28410749 |
2017 |
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
Fenofibrate, a PPAR-α inhibitor used for treating dyslipidemia, has well-documented anti-inflammatory effects that vary between individuals.
|
28835163 |
2017 |
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
Our findings suggest that RKE, containing LIA, OA, and HODEs, could be valuable in improving dyslipidemia via PPARα activation.
|
27934292 |
2016 |
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
To our knowledge, this is the first study to report that 9-oxo-OTA promotes fatty acid metabolism via PPARα activation and discuss its potential as a valuable food-derived compound for use in the management of dyslipidemia.
|
26387026 |
2015 |
Dyslipidemias
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The aim of the study was to scrutinize the effect of Clematichinenoside (AR) on dyslipidemia-induced atherosclerosis and explore its capability on expression of Peroxisome proliferator-activated receptor-α (PPAR-alpha), apolipoprotein A-I (APOA1) and A-II (APOA2), and suppression of apolipoprotein C-III (APOC3) genes and proteins.
|
25979856 |
2015 |
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
Fenofibrate, a peroxisome proliferator-activated receptor alpha (PPAR-α) agonist, has been used for decades to treat hypertriglyceridaemia and mixed dyslipidaemia.
|
24529079 |
2014 |
Dyslipidemias
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The objective was to investigate the associations of the PPAR α and PPAR γ polymorphisms with dyslipidemia.
|
24460649 |
2014 |
Dyslipidemias
|
0.400 |
GeneticVariation
|
group |
BEFREE |
There is evidence that genetic variants within the PPARα gene have been associated with a risk of the development of dyslipidemia and cardiovascular disease by influencing fasting and postprandial lipid concentrations; the gene variants have also been associated with an acceleration of the progression of type 2 diabetes.
|
23858092 |
2013 |
Dyslipidemias
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The objective of this study was to assess the distribution of the APOE, SCARB1, PPARα genotypes in the Lithuanian adult population and to determine the relationship of these genotypes with dyslipidemia.
|
23919842 |
2013 |
Dyslipidemias
|
0.400 |
GeneticVariation
|
group |
BEFREE |
PPARα polymorphisms as risk factors for dyslipidemia in a Brazilian population.
|
21159535 |
2011 |
Dyslipidemias
|
0.400 |
AlteredExpression
|
group |
BEFREE |
PPARα is activated by fibrates, hypolipidemic drugs used in the treatment of dyslipidemia.
|
21474829 |
2011 |
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
Fibrates, the ligands of peroxisome proliferator-activated receptor alpha (PPARalpha), are used as a class of lipid-lowering drugs in clinical practice for the treatment of dyslipidemia.
|
19683050 |
2010 |
Dyslipidemias
|
0.400 |
GeneticVariation
|
group |
BEFREE |
to assess the effect of functional single nucleotide polymorphisms (SNPs) of PPARα and PPARγ2, previously associated with insulin resistance and dyslipidemia, on liver damage in NAFLD, whose progression is influenced by metabolic abnormalities and inherited factors.
|
20825652 |
2010 |
Dyslipidemias
|
0.400 |
Biomarker
|
group |
BEFREE |
PPARalpha ligand fibrates have been used for the treatment of dyslipidemia due to their ability to lower plasma triglyceride levels and elevate HDL cholesterol levels.
|
19646654 |
2009 |