TET2, tet methylcytosine dioxygenase 2, 54790

N. diseases: 362; N. variants: 47
Disease: Myelofibrosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026987
Disease: Myelofibrosis
Myelofibrosis 		0.340 GeneticVariation disease BEFREE In primary MF, inferior OS was associated with male gender (P = 0.03), haemoglobin < 10 g/dL (P = 0.002), platelet count < 100 × 10<sup>9</sup>/L (P = 0.02), TET2 mutation (P = 0.01) and CUX1 mutation (P = 0.01); and inferior LFS was associated with haemoglobin < 10 g/dL (P = 0.02), platelet count < 100 × 10<sup>9</sup>/L (P = 0.02), TET2 mutations (P = 0.01) and CUX1 mutations (P = 0.04). 30515541 2019
CUI: C0026987
Disease: Myelofibrosis
Myelofibrosis 		0.340 GeneticVariation disease BEFREE We found that blast phase of PV was characterized by overt myelodysplasia (n = 51, 88%); moderate to severe myelofibrosis (33 of 45, 73%); an abnormal karyotype (n = 51, 88%) that was often complex karyotype (n = 42, 72%); and gene mutations involving TP53 (55%), TET2 (27%), and DNMT3A (25%). 29285580 2018
CUI: C0026987
Disease: Myelofibrosis
Myelofibrosis 		0.340 GeneticVariation disease BEFREE TET2 mutations were mainly observed (10 of 12) in patients with primary myelofibrosis or patients with polycythemia vera or essential thrombocythemia who secondarily evolved toward myelofibrosis or acute myeloid leukemia. 19564637 2009
CUI: C0026987
Disease: Myelofibrosis
Myelofibrosis 		0.340 SomaticCausalMutation disease ORPHANET TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis. 19262601 2009
CUI: C0026987
Disease: Myelofibrosis
Myelofibrosis 		0.340 SomaticCausalMutation disease ORPHANET TET2 mutations in myelodysplasia and myeloid malignancies. 19557078 2009
CUI: C0026987
Disease: Myelofibrosis
Myelofibrosis 		0.340 GeneticVariation disease BEFREE TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis. 19262601 2009