Heart Failure, Diastolic
|
0.300 |
Biomarker
|
disease |
CTD_human |
In Silico Analysis of Differential Gene Expression in Three Common Rat Models of Diastolic Dysfunction.
|
29556499 |
2018 |
Malignant Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Epsin 3 (EPN3) expression is limited to gastric parietal cells and wounded or pathological tissue rather than normal brain tissue, and although it has been identified as an oncogene in estrogen receptor‑positive breast cancer and non‑small cell lung cancer, its function in cancer is poorly understood.
|
30226603 |
2018 |
Primary malignant neoplasm
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Epsin 3 (EPN3) expression is limited to gastric parietal cells and wounded or pathological tissue rather than normal brain tissue, and although it has been identified as an oncogene in estrogen receptor‑positive breast cancer and non‑small cell lung cancer, its function in cancer is poorly understood.
|
30226603 |
2018 |
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
In contrast, only one late-type gene (EPN3) showed consistent survival associations in more than one cohort in the other cancer types, being associated with worse outcome in two non-small cell lung cancer cohorts.
|
27926932 |
2016 |
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
In contrast, only one late-type gene (EPN3) showed consistent survival associations in more than one cohort in the other cancer types, being associated with worse outcome in two non-small cell lung cancer cohorts.
|
27926932 |
2016 |
Non-Small Cell Lung Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Epsin 3 (EPN3) expression is limited to gastric parietal cells and wounded or pathological tissue rather than normal brain tissue, and although it has been identified as an oncogene in estrogen receptor‑positive breast cancer and non‑small cell lung cancer, its function in cancer is poorly understood.
|
30226603 |
2018 |
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggested that EPN3 enhances the migration and invasion of glioblastoma cells by activating the transcription factors Slug, Twist and ZEB1, but not Snail 1 or ZEB2, to induce EMT in glioma cells; EPN3 involvement in the Notch and WNT/β‑catenin signaling pathways may contribute to this process.
|
30226603 |
2018 |
Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
EPN3 expression was assessed by immunohistochemistry in tissue samples from 167 patients with glioma, as well as by western blotting in 5 glioblastoma cell lines.
|
30226603 |
2018 |
Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
No significant differences were observed in EPN3 expression in relation to patient age, sex or tumor size.
|
30226603 |
2018 |
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggested that EPN3 enhances the migration and invasion of glioblastoma cells by activating the transcription factors Slug, Twist and ZEB1, but not Snail 1 or ZEB2, to induce EMT in glioma cells; EPN3 involvement in the Notch and WNT/β‑catenin signaling pathways may contribute to this process.
|
30226603 |
2018 |
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggested that EPN3 enhances the migration and invasion of glioblastoma cells by activating the transcription factors Slug, Twist and ZEB1, but not Snail 1 or ZEB2, to induce EMT in glioma cells; EPN3 involvement in the Notch and WNT/β‑catenin signaling pathways may contribute to this process.
|
30226603 |
2018 |
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of EPN3 promoted glioblastoma cell migration and invasion, which we hypothesized was through affecting epithelial‑mesenchymal transition (EMT).
|
30226603 |
2018 |
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggested that EPN3 enhances the migration and invasion of glioblastoma cells by activating the transcription factors Slug, Twist and ZEB1, but not Snail 1 or ZEB2, to induce EMT in glioma cells; EPN3 involvement in the Notch and WNT/β‑catenin signaling pathways may contribute to this process.
|
30226603 |
2018 |
Oestrogen receptor positive breast cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Epsin 3 (EPN3) expression is limited to gastric parietal cells and wounded or pathological tissue rather than normal brain tissue, and although it has been identified as an oncogene in estrogen receptor‑positive breast cancer and non‑small cell lung cancer, its function in cancer is poorly understood.
|
30226603 |
2018 |
Gastric Adenocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, we evaluated EPSIN 3 expression levels in various tissues, including gastric adenocarcinoma, human gastric mucosa with or without Helicobacter pylori infection, and mouse acute gastritis tissues induced by indomethacin.
|
28152424 |
2017 |
Neoplasm Metastasis
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
In contrast, high expression of epsin (EPN3) was associated with increased risk of late metastasis.
|
27926932 |
2016 |
Tumor Angiogenesis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Four of the ten late-type genes, the ribosome-related factors EIF4B, RPL5, RPL3, and the tumor angiogenesis modifier EPN3 were significantly associated with MFS in the late period also in a meta-analysis of tamoxifen-treated breast cancer cohorts.
|
27926932 |
2016 |
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we show that epsin 3 is selectively expressed at high levels in the stomach (including the majority of gastric cancers), where it is concentrated in parietal cells.
|
21115825 |
2010 |