Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Insulin-Dependent
0.100 GeneticVariation disease BEFREE In type 1 diabetes mellitus (T1DM), autoantibodies show specificity for binding two variants of ZnT8 (R or W at amino acid 325) dictated by a polymorphism in <i>SLC30A8</i>. 30936916 2019
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE In this review, we consider the contribution made by ZnT8 to our understanding of type 1 diabetes over the past decade and what remains to be investigated in future research. 31444530 2019
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE The autoantibodies against glutamic acid decarboxylase (GADA), insulinoma antigen-2 (IA-2A), insulin (IAA), and zinc transporter-8 (ZnT-8A) comprise the most reliable biomarkers for type 1 diabetes in both children and adults. 31827651 2019
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE However, those with later onset type 1 diabetes had a modestly lower type 1 diabetes genetic risk score (0.268 vs 0.279; p < 0.001 [expected type 2 diabetes population median, 0.231]), a higher islet autoantibody prevalence (GAD-, islet antigen 2 [IA2]- or zinc transporter protein 8 [ZnT8]-positive) of 78% at 13 years vs 62% at 26 years of diabetes duration; (p = 0.02), and were less likely to identify as having type 1 diabetes (79% vs 100%; p < 0.001) vs those with young-onset disease. 30969375 2019
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE Zinc transporter 8 (ZnT8) is a novel immunodominant autoantigen, associated with Type-1 diabetes. 30710592 2019
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE The incidence of GADA and ZnT8A in patients with GD is high and might indicate wide range endocrine autoimmunity, as well as risk for non-autoimmune diabetes rather than exclusively mark beta cell autoimmunity and type 1 diabetes. 30783963 2019
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE Type 1 diabetes (T1D)-associated autoantibodies (DAAs) were present in two patients (both of whom had anti-glutamic acid decarboxylase antibody); all were negative for insulin-associated protein 2, insulin, and ZnT8. 31265074 2019
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE Zinc transporter 8 (ZnT8) is a multi-transmembrane protein situated in the insulin secretory granule of the islets of β-cells and is identified as a novel auto-antigen in type 1 diabetes (T1D). 30197307 2019
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE Background Zinc transporter 8 autoantibodies (ZnT8Abs) together with glutamic acid decarboxylase autoantibodies (GADAbs), insulinoma antigen 2 autoantibodies (IA-2Abs) and insulin autoantibodies (IAbs) are markers of type 1 diabetes mellitus (T1DM). 30903759 2019
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE Zinc transporter 8 autoantibodies (ZnT8-ab) are associated with higher prevalence of multiple diabetes-related autoantibodies in adults with type 1 diabetes. 30465779 2018
Diabetes Mellitus, Insulin-Dependent
0.100 GeneticVariation disease BEFREE Among patients with ketosis-prone diabetes (KPD), characterized by presentation with diabetic ketoacidosis (DKA), >60% of adults lack three classic islet autoantibodies-IA-2, GAD65, and ZnT8 Abs-associated with type 1 diabetes. 30327357 2018
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE The aim of this study was to investigate the prevalence of ZnT8A in Turkish children with new onset T1D. 28943512 2018
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE For this purpose, we evaluated the prevalence of islets cells antibodies (ICA), glutamic acid decarboxylase (GAD), islet antigen type 2 (IA2), insulin (IA) autoantibodies (ab) and for the first time in Algeria, the zinc transporter 8 (ZnT8) in young Algerian patients with type 1 diabetes. 29487039 2018
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE Importance of Zinc Transporter 8 Autoantibody in the Diagnosis of Type 1 Diabetes in Latin Americans. 28303020 2017
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE Type 1 diabetes (T1D) is now predictable by measuring major islet autoantibodies (IAbs) against insulin and other pancreatic β cells proteins including GAD65 (GADA), islet antigen 2 (IA-2A), and zinc transporter 8 (ZnT8A). 28509692 2017
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE Our PLR-ZnT8/pGOLD exhibited efficient ZnT8A detection for T1D diagnosis with ∼76% sensitivity and ∼97% specificity (<i>n</i> = 307), superior to assays based on detergent-solubilized full-length ZnT8 and the C-terminal domain of ZnT8. 28874568 2017
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE Islet-targeting autoantibodies that target insulin, 65 kDa glutamic acid decarboxylase, insulinoma-associated protein 2 and zinc transporter 8 - all of which are proteins associated with secretory granules in β-cells - are biomarkers of T1DM-associated autoimmunity that are found months to years before symptom onset, and can be used to identify and study individuals who are at risk of developing T1DM. 28358037 2017
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE A total of 31 Somali children ≤19 yr were treated for type 1 diabetes (T1D) at the University of Minnesota Masonic Children's Hospital and Children's Hospitals and Clinics of Minnesota underwent analysis of human leukocyte antigen (HLA) alleles (n = 30) and diabetes autoantibodies [glutamic acid decarboxylase (GAD65), islet antigen 2 (IA-2), zinc transporter 8 (ZnT8); n = 31]. 26854192 2017
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE Furthermore, we wanted to confirm the prevalence of zinc transporter 8 autoantibodies (ZnT8A), as previously reported, in a larger population and study its predictive value in relation to other β cell specific autoantibodies in postpartum development of type 1 diabetes. 27003436 2016
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE These ZnT8-specific scFvs are potential agents in immunodiagnostic and immunotherapy of T1D. 27270580 2016
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE Type 1 Diabetes at-risk children highly recognize Mycobacterium avium subspecies paratuberculosis epitopes homologous to human Znt8 and Proinsulin. 26923214 2016
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE Relative resistance to DM-mediated editing of CLIP was further confirmed by HPLC-MS/MS analysis of eluted peptides, which also demonstrated peptides from known T1D-associated autoantigens, including a shared epitope from ZnT8 that is presented by all four major T1D-susceptible DQ molecules. 26707565 2016
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE No correlation between ZnT8 detection and the number of T1DM-susceptible HLA-DQ heterodimers was found. 27487045 2016
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE Positivity for Zinc Transporter 8 Autoantibodies at Diagnosis Is Subsequently Associated With Reduced β-Cell Function and Higher Exogenous Insulin Requirement in Children and Adolescents With Type 1 Diabetes. 26519333 2016
Diabetes Mellitus, Insulin-Dependent
0.100 Biomarker disease BEFREE ZnT8(107-116)(115), ZnT8(115-123), ZnT8(153-161), ZnT8(177-186) and ZnT8(291-300) represent potentially major biomarkers for T1D. 26541133 2016