|
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
BEFREE |
Bioinformatics analysis predicted that there is a SPRY4-IT1/miR-101-3p/AMPK axis in GC progression.
|
31330497 |
2019 |
|
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
BEFREE |
PRKAA1 knockdown in GC cells showed significant decreases in the cell invasion and migration and inhibited MMP-2 expression and NF-κB activation, whereas PRKAA1 involved in NF-κBp50 mediated GC cell invasion and migration.
|
31841039 |
2019 |
|
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
BEFREE |
Adrenergic modulation of AMPK‑dependent autophagy by chronic stress enhances cell proliferation and survival in gastric cancer.
|
30896863 |
2019 |
|
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
BEFREE |
LKB1-AMPK activation in GC cell lines was tumor suppressive, as metformin (an AMPK activator) inhibited GC cell growth in the CAB39L-silenced cells.
|
30054562 |
2018 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to evaluate the association between TLR1 and PRKAA1 genes polymorphisms and H. pylori infection, atrophic gastritis (AG) or GC in the European population.
|
30574617 |
2018 |
|
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
BEFREE |
However, the Kaplan-Meier estimate showed that there is no significant difference of OS and RFS between the low and high PRKAA1 TPM groups in gastric cancer, breast cancer, and esophageal carcinoma.
|
30340465 |
2018 |
|
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
BEFREE |
MTDH-stimulated cancer resistance to 5-FU may be mediated through autophagy activated by the AMPK/ATG5 pathway in GC.
|
29635244 |
2018 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations in PRKAA1 predict the risk and progression of gastric Cancer.
|
30253744 |
2018 |
|
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
BEFREE |
The anti-gastric cancer mechanism of BBR might be involved in AMPK-HNF4α-WNT5A signaling pathway.
|
30405404 |
2018 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, in analyses stratified by either source of control or geographical origin of subjects, a statistically significant inverse relationship was detected between <i>PRKAA1 rs13361707</i> C/T polymorphism and GC risk.
|
28978122 |
2017 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results indicated that H. pylori infection, CagA status, and PRKAA1 polymorphisms were risk factors for gastric cancer in Koreans, and that the combination of two of these factors rather than their independent effects synergistically increased the risk.
|
27726301 |
2016 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results confirm an association between gastric cancer in Europeans and three loci previously reported in Asians, MUC1, PRKAA1 and PSCA, refine the association signal at PRKAA1 and support a pathogenic role for the tandem repeat identified in MUC1.
|
26098866 |
2015 |
|
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our results demonstrate that CAMKK2 signals in gastric cancer through AMPK activation and suggest that CAMKK2 could be a novel therapeutic target in gastric cancer.
|
25756516 |
2015 |
|
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
CTD_human |
Our results confirm an association between gastric cancer in Europeans and three loci previously reported in Asians, MUC1, PRKAA1 and PSCA, refine the association signal at PRKAA1 and support a pathogenic role for the tandem repeat identified in MUC1.
|
26098866 |
2015 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In summary, these results indicated that the C allele of PRKAA1 rs13361707 was a low-penetrate risk factor for GCa.
|
26485766 |
2015 |
|
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
BEFREE |
The PRKAA1 gene showed a significant gene-based association with gastric cancer in the VEGAS test.
|
25024613 |
2014 |
|
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
BEFREE |
We identified HNF4α-WNT5A regulation in the cross-talk between the AMPK metabolic pathway and the WNT signaling pathway, and further identified WNT5A as a potential therapeutic target for GC.
|
24681952 |
2014 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic variations in the PRKAA1 and ZBTB20 genes and gastric cancer susceptibility in a Korean population.
|
23861218 |
2013 |
|
Insulin Resistance
|
0.500 |
Biomarker
|
phenotype |
RGD |
These findings indicated that the decrease in lipin1 expression and AMPKα activation may contribute to hepatic insulin resistance in diet-induced obese rats.
|
22231922 |
2012 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1.
|
22037551 |
2011 |
|
Insulin Resistance
|
0.500 |
Biomarker
|
phenotype |
CTD_human |
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol.
|
19934007 |
2010 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this study we showed that treatment with ouabain (25 nM) caused simultaneous activation of AMPK and Src signaling pathways in human lung cancer A549 cells and human breast cancer MCF7 cells.
|
31515527 |
2020 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
We demonstrate the translational potential of an AMPK and BCL-2/BCL-X<sub>L</sub> co-targeting strategy in ex vivo and in vivo models of MYC-high breast cancer.
|
30728358 |
2019 |
|
Malignant neoplasm of breast
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we hypothesized that AMPK as a key metabolic regulator plays a crucial role in regulation of breast cancer drug resistance, which could be alleviated by treatment of CTAB.
|
31402869 |
2019 |
|
Malignant neoplasm of breast
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Also suppression of AMPK abrogated inhibitory effect of phytosomal-curcumin on thrombin-induced cyclin D1 over-expression, suggesting that AMPK is essential for anti-proliferative effect of this agent in breast cancer.
|
29600521 |
2018 |