PRKCE, protein kinase C epsilon, 5581

N. diseases: 112; N. variants: 51
Disease: Hyperalgesia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.320 Biomarker phenotype BEFREE Protein kinase C ε (PKCε) AS-ODN also prevented LDM-induced hyperalgesia and priming, whereas analgesia and priming induced by HDM were unaffected. 31209174 2019
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.320 Biomarker phenotype CTD_human While PKCepsilon activation can induce acute hyperalgesia in the IB4(+) population, it fails to induce priming. 20457222 2010
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.320 Biomarker phenotype LHGDN Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice. 16793902 2006
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.320 Biomarker phenotype CTD_human Injection of 5- and 12-lipoxygenase produced hyperalgesia that was not antagonized by inhibitors of PKA, PKCepsilon or MAPK.These findings suggest that: (1). lipoxygenase products of arachidonic acid function as second messengers in the peripheral hyperalgesia induced by agents that act directly on primary afferent nociceptors (epinephrine and prostaglandin E(2)), (2). products of the 5-lipoxygenase and 12-lipoxygenase pathway are involved in this function, and (3). these lipoxygenase products contribute to hyperalgesia at or downstream of protein kinase A and PKCepsilon. 12582831 2003
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.320 Biomarker phenotype CTD_human Role of protein kinase Cepsilon and protein kinase A in a model of paclitaxel-induced painful peripheral neuropathy in the rat. 11738263 2001