PRKCE, protein kinase C epsilon, 5581

N. diseases: 112; N. variants: 51
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.310 Biomarker phenotype BEFREE Furthermore, linear analysis results showed that the densities of p-PKCε and Bcl-<sub>XL</sub> had a reverse linear relationship with the degrees of thermal hyperalgesia and mechanical allodynia. 30679921 2019
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.310 Biomarker phenotype CTD_human Thus, while PKCepsilon is present in most dorsal root ganglion neurons, where it can contribute to acute mechanical hyperalgesia, priming is restricted to IB4(+)-nociceptors, including those that are TrkA(+). 20457222 2010
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.310 Biomarker phenotype CTD_human We evaluated the role of lipoxygenase products of arachidonic acid metabolism in mechanical hyperalgesia induced by epinephrine, an agent that directly sensitizes nociceptors to produce mechanical hyperalgesia via three second messenger signaling pathways, protein kinase A (PKA), protein kinase C epsilon (PKCepsilon), and mitogen activated protein kinase (MAPK). 12582831 2003
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia
0.310 Biomarker phenotype CTD_human Role of protein kinase Cepsilon and protein kinase A in a model of paclitaxel-induced painful peripheral neuropathy in the rat. 11738263 2001