PRNP, prion protein, 5621

N. diseases: 426; N. variants: 47
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036457
Disease: Scrapie
Scrapie
0.550 GeneticVariation disease BEFREE In silico investigation of the prion protein glycosylation profiles in relation to scrapie disease resistance in domestic sheep (Ovis aries). 30261281 2018
CUI: C0036457
Disease: Scrapie
Scrapie
0.550 ModifyingMutation disease RGD A novel vector for transgenesis in the rat CNS. 29157304 2017
CUI: C0036457
Disease: Scrapie
Scrapie
0.550 Biomarker disease CTD_human The aim of this study is to investigate the profile of ovine PrP gene by amino acid polymorphism at codons 136, 141, 154, and 171 for determining the genetic predisposition to the Scrapie disease for the tribal sheep and rams, with different numbers and distribution in Bulgaria. 21533749 2011
CUI: C0036457
Disease: Scrapie
Scrapie
0.550 Biomarker disease CTD_human The effect of metal imbalances on scrapie neurodegeneration. 19486493 2010
CUI: C0036457
Disease: Scrapie
Scrapie
0.550 Biomarker disease CTD_human Scrapie infection stimulated Gpc-1 autoprocessing and the generated HS degradation products colocalized with intracellular aggregates of the disease-related scrapie prion protein isoform (PrP(Sc)). 18717736 2008
CUI: C0036457
Disease: Scrapie
Scrapie
0.550 AlteredExpression disease BEFREE Cerebral and cardiac amyloid deposits have been reported after scrapie infection in transgenic mice expressing variant prion protein (PrP(C)) lacking the glycophosphatidylinositol anchor. 17955450 2007
CUI: C0036457
Disease: Scrapie
Scrapie
0.550 Biomarker disease CTD_human Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities. 11701772 2001
CUI: C0036457
Disease: Scrapie
Scrapie
0.550 Biomarker disease BEFREE The complex relationships between PrP genotype and the survival of sheep subjected to scrapie infection are now being investigated in terms of the different structure of the PrP protein molecules produced by each allele. 9718582 1998
CUI: C0036457
Disease: Scrapie
Scrapie
0.550 Biomarker disease BEFREE All of the findings with different PrP constructs plus the absence of scrapie pathology in PrP null mice are the strongest argument that the prion protein is the main etiologic and pathogenic factor of prion disorders. 7913760 1994
CUI: C0036457
Disease: Scrapie
Scrapie
0.550 Biomarker disease BEFREE Transgenic mouse studies are emphasized which verify that genetic forms of TSEs are linked to mutations in the host PrP gene and that the host species barrier to scrapie infection, scrapie incubation time and the distribution of neuropathology, which define scrapie prion isolates ('strains'), are determined by the structure of PrP. 8137126 1993