New Variant Creutzfeldt-Jakob Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
The presence of abnormal, disease-related prion protein (PrP<sup>D</sup>) has recently been demonstrated by protein misfolding cyclic amplification (PMCA) in urine of patients affected with variant Creutzfeldt-Jakob disease (vCJD), a prion disease typically acquired from consumption of prion contaminated bovine meat.
|
30914754 |
2019 |
New Variant Creutzfeldt-Jakob Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Variant Creutzfeldt-Jakob disease strain is identical in individuals of two PRNP codon 129 genotypes.
|
30938429 |
2019 |
New Variant Creutzfeldt-Jakob Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Abnormal prion protein (PrP<sup>TSE</sup>) extracted from the brains of vCJD-infected TgBo110 mice displayed different glycosylation profiles and had greater resistance to denaturation by guanidine hydrochloride than PrP<sup>TSE</sup> from infected wild-type mice or from either inoculum.
|
29458529 |
2018 |
New Variant Creutzfeldt-Jakob Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here we report that serial passage of experimental sheep BSE prions in transgenic mice expressing human prion protein with methionine at residue 129 produces the vCJD phenotype that mirrors that seen when the same mice are challenged with vCJD prions from patient brain.
|
29406965 |
2018 |
New Variant Creutzfeldt-Jakob Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Transfusion transmission of human prion diseases has been observed for variant Creutzfeldt-Jakob disease (vCJD), but not for the classic forms of prion disease (CJD: sporadic, genetic, and iatrogenic).
|
28444687 |
2017 |
New Variant Creutzfeldt-Jakob Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
We analyzed 128 suitable frontal cortex samples, from prion-affected patients (variant Creutzfeldt-Jakob disease (vCJD) n = 20, iatrogenic CJD (iCJD) n = 11, sporadic CJD (sCJD) n = 23, familial CJD (gCJD) n = 17, fatal familial insomnia (FFI) n = 9, Gerstmann-Sträussler-Scheinker syndrome (GSS)) n = 4), patients with Alzheimer disease (AD, n = 14) and age-matched controls (n = 30).
|
29142239 |
2017 |
New Variant Creutzfeldt-Jakob Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Recently, we have demonstrated PrP(TSE) in extracellular vesicle preparations (EVs) containing exosomes from plasma of mice infected with mouse-adapted vCJD by Protein Misfolding Cyclic Amplification (PMCA).
|
27499183 |
2016 |
New Variant Creutzfeldt-Jakob Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Besides the molecular typing of protease-resistant PrP in the brain, transmission studies using knock-in mice carrying bovine PrP may aid the differential diagnosis of secondary vCJD infection, especially in individuals with the 129V/V genotype.
|
23792955 |
2013 |
New Variant Creutzfeldt-Jakob Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
We investigated the effect of this polymorphism on amplification of human and macaque vCJD PrP(TSE).
|
24205298 |
2013 |
New Variant Creutzfeldt-Jakob Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This individual was heterozygous (MV) at codon 129 of the prion protein gene (PRNP), whereas all previous definite and probable cases of variant Creutzfeldt-Jakob disease have been methionine homozygotes (MM).
|
23449776 |
2013 |
New Variant Creutzfeldt-Jakob Disease
|
0.600 |
Biomarker
|
disease |
CTD_human |
Snord 3A: a molecular marker and modulator of prion disease progression.
|
23349890 |
2013 |
New Variant Creutzfeldt-Jakob Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our study reveals 2 new genome-wide significant markers for vCJD outside PRNP and provides evidence supporting a role of the phosphatidylinositol pathway in vCJD susceptibility.
|
22137330 |
2012 |
New Variant Creutzfeldt-Jakob Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Correlation of polydispersed prion protein and characteristic pathology in the thalamus in variant Creutzfeldt-Jakob disease: implication of small oligomeric species.
|
21029243 |
2011 |
New Variant Creutzfeldt-Jakob Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In contrast, variant Creutzfeldt-Jakob disease (vCJD), which results from oral exposure to the agent of bovine spongiform encephalopathy, is a highly stereotyped disease, that, until now, has only occurred in patients who are methionine homozygous at codon 129 of the PrP gene.
|
21790605 |
2011 |
New Variant Creutzfeldt-Jakob Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
This technique also allows a greatly enhanced sensitivity of detection of disease-associated prion protein in human tissues and fluids, which is potentially applicable to disease screening, particularly for variant Creutzfeldt-Jakob disease.
|
20535485 |
2011 |
New Variant Creutzfeldt-Jakob Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
The diagnosis was confirmed by a tonsillar biopsy demonstrating abnormal prion protein deposition in a typical pattern for vCJD.
|
20697057 |
2010 |
New Variant Creutzfeldt-Jakob Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We describe a study to detect disease-associated, protease-resistant prion protein (PrP(res)) in 17 neurologically aymptomatic patients with haemophilia considered to be at increased risk of vCJD.
|
20070383 |
2010 |
New Variant Creutzfeldt-Jakob Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Strain-specific viral properties of variant Creutzfeldt-Jakob disease (vCJD) are encoded by the agent and not by host prion protein.
|
19097123 |
2009 |
New Variant Creutzfeldt-Jakob Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
For example, cross-sequence transmission of bovine spongiform encephalopathy (BSE) prions to human generated variant Creutzfeldt-Jakob disease (vCJD) prions which retained the transmissibility to mice expressing bovine PrP.
|
19659941 |
2009 |
New Variant Creutzfeldt-Jakob Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Human prion protein (PrP) 219K is converted to PrPSc but shows heterozygous inhibition in variant Creutzfeldt-Jakob disease infection.
|
19074151 |
2009 |
New Variant Creutzfeldt-Jakob Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although the main contribution to disease risk was conferred by PRNP polymorphic codon 129, another nearby SNP conferred increased risk of vCJD.
|
19081515 |
2009 |
New Variant Creutzfeldt-Jakob Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
So far, all clinical cases of new variant Creutzfeldt-Jakob disease (vCJD), thought to result from the Bovine Spongiform Encephalopathy (BSE) prion agent, have shown Methionine-Methionine (M/M) homozygosity at the M129V polymorphism of the PRNP gene.
|
19495414 |
2009 |
New Variant Creutzfeldt-Jakob Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
The single monkey infected with BASE had a shorter survival, and a different clinical evolution, histopathology, and prion protein (PrPres) pattern than was observed for either classical BSE or vCJD-inoculated animals.
|
18714385 |
2008 |
New Variant Creutzfeldt-Jakob Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Archival kuru and recent variant Creutzfeldt-Jakob disease (vCJD) cases reveal distinct lesional differences, particularly with respect to prion protein, suggesting that the strain of agent is important in determining the phenotype.
|
18849282 |
2008 |
New Variant Creutzfeldt-Jakob Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Paired-pulse stimulation of the Schaffer collaterals evoked hypersynchronous bursting in the hippocampus of vCJD-inoculated mice; comparable bursts were never observed in control or Prnp knockout mice, or in mice inoculated with a strain of prion associated with classical CJD.
|
18638557 |
2008 |