PRNP, prion protein, 5621

N. diseases: 426; N. variants: 47
Disease: Human Transmissible Spongiform Encephalopathies, Inherited ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0751645
Disease: Human Transmissible Spongiform Encephalopathies, Inherited
Human Transmissible Spongiform Encephalopathies, Inherited 		0.310 Biomarker disease CTD_human Physiopathologic implications of the structural and functional domains of the prion protein. 17274528 2007
CUI: C0751645
Disease: Human Transmissible Spongiform Encephalopathies, Inherited
Human Transmissible Spongiform Encephalopathies, Inherited 		0.310 Biomarker disease CTD_human The copper(II) adduct of the unstructured region of the amyloidogenic fragment derived from the human prion protein is redox-active at physiological pH. 17257012 2007
CUI: C0751645
Disease: Human Transmissible Spongiform Encephalopathies, Inherited
Human Transmissible Spongiform Encephalopathies, Inherited 		0.310 Biomarker disease CTD_human Filipin prevents pathological prion protein accumulation by reducing endocytosis and inducing cellular PrP release. 11994310 2002
CUI: C0751645
Disease: Human Transmissible Spongiform Encephalopathies, Inherited
Human Transmissible Spongiform Encephalopathies, Inherited 		0.310 Biomarker disease CTD_human Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities. 11701772 2001
CUI: C0751645
Disease: Human Transmissible Spongiform Encephalopathies, Inherited
Human Transmissible Spongiform Encephalopathies, Inherited 		0.310 GeneticVariation disease BEFREE The refined NMR structure of the mouse prion protein domain mPrP(121-231) and the recently reported NMR structure of the complete 208-residue polypeptide chain of mPrP are used to investigate the structural basis of inherited human transmissible spongiform encephalopathies. 9751723 1998