RELN, reelin, 5649

N. diseases: 178; N. variants: 52
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 GeneticVariation disease BEFREE Polymorphisms in RELN have been implicated in related disorders like autism and schizophrenia but have not been examined in dyslexia. 30199849 2018
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 GeneticVariation disease BEFREE Two single-nucleotide polymorphisms of the RELN gene and symptom-based and developmental deficits among children and adolescents with autistic spectrum disorders in the Tianjin, China. 29753726 2018
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 Biomarker disease BEFREE Reelin had been proposed to participate in the etiology of autism due to its important role in brain development. 26285919 2016
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 GeneticVariation disease BEFREE The g.333509A>C in intron12 and g.504742G>A in exon60 were detected in the RELN gene and a significant association was found between the g.504742G>A polymorphism and autism. 23287318 2015
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 Biomarker disease BEFREE DAB1, VLDLR/APOER2, FYN/SRC and CRK/CRKL) are deficient have the similar phenotype as the reeler mice (Reelin(-/-)), we hypothesized that the Reelin signaling pathway genes might play roles in the etiology of autism. 23333377 2013
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 GeneticVariation disease BEFREE The aim of the present study was to find the genetic association of intronic rs736707 and exonic rs362691 (single-nucleotide polymorphisms [SNPs] of the RELN gene) with autism in a SA population. 23216241 2013
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 Biomarker disease BEFREE Our results strengthen the case for a more detailed study of the role of RELN and GRIK2 in autism susceptibility, as well as identifying two new potential candidate genes, MKL2 and SND1. 20442744 2010
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 Biomarker disease BEFREE The only significant association in autistic boys in Slovakia was found with higher number of GGC repeats in the RELN gene (P=0.001) potentially explaining lower RELN levels in blood and brain of autistic patients. 20436377 2010
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 Biomarker disease CTD_human Our results strengthen the case for a more detailed study of the role of RELN and GRIK2 in autism susceptibility, as well as identifying two new potential candidate genes, MKL2 and SND1. 20442744 2010
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 AlteredExpression disease BEFREE Excessive RELN promoter methylation and/or decreased RELN gene expression have been described in schizophrenia and autism. 19952965 2010
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 Biomarker disease BEFREE A number of genetic studies have been carried out to investigate the association of reelin with autism. 18597938 2008
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 Biomarker disease BEFREE Therefore, both RELN and GRM8 genes are considered to be not only the positional but also the functional candidate genes to autism for association research. 17955477 2008
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 GeneticVariation disease LHGDN Thus, the present study suggests that 5'UTR of reelin gene may have a role in the susceptibility towards autism with the paternal transmission and non-transmission respectively of 10- and > or =11-repeat alleles, to the affected offspring. 16941662 2007
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 GeneticVariation disease BEFREE These families were genotyped for 11 RELN polymorphisms, including the 5' untranslated region repeat previously associated with autism, as well as for the APOE functional allele. 17621165 2007
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 GeneticVariation disease BEFREE Thus, the present study suggests that 5'UTR of reelin gene may have a role in the susceptibility towards autism with the paternal transmission and non-transmission respectively of 10- and > or =11-repeat alleles, to the affected offspring. 16941662 2007
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 AlteredExpression disease BEFREE Several reports suggest that reduced reelin expression is associated with human mental illnesses such as schizophrenia, mood disorders and autism. 16556465 2006
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 Biomarker disease BEFREE Our findings support a role for the Reelin gene in the susceptibility to autism. 16311013 2006
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 Biomarker disease BEFREE From this body of work we highlight results from three candidate genes, REELIN (RELN), SEROTONIN TRANSPORTER (5HTT), and ENGRAILED 2 (EN2) and discuss the relevant neuroscience, molecular genetics, and statistical results that suggest involvement of these genes in autism susceptibility. 15749247 2005
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 Biomarker disease BEFREE Reductions in Reelin protein and mRNA and Dab 1 mRNA and elevations in Reln receptor VLDLR mRNA demonstrate impairments in the Reelin signaling system in autism, accounting for some of the brain structural and cognitive deficits observed in the disorder. 15820235 2005
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 GeneticVariation disease BEFREE The total data set consists of 218 Caucasian families collected by our group, 85 Caucasian families collected by AGRE, and 68 Caucasian families collected at Tufts University were tested for genetic association of RELN variants to autism. 15558079 2005
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 GeneticVariation disease BEFREE We have previously described linkage/association between reelin gene polymorphisms and autistic disorder. 15167692 2004
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 GeneticVariation disease BEFREE Several recent candidate gene studies have suggested that alleles of WNT2 and the reelin gene (RELN), two genes involved in distinct aspects of neurodevelopment, confer greater susceptibility to autism. 15048648 2004
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 GeneticVariation disease LHGDN Several recent candidate gene studies have suggested that alleles of WNT2 and the reelin gene (RELN), two genes involved in distinct aspects of neurodevelopment, confer greater susceptibility to autism. 15048648 2004
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 GeneticVariation disease BEFREE Our results are not consistent with a major role for Reelin alleles in liability to autism. 15048647 2004
CUI: C0004352
Disease: Autistic Disorder
Autistic Disorder
0.400 Biomarker disease BEFREE Several studies have reported evidence for an association between autism and the Reelin gene. 14755445 2004