Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We recently found that the low-density lipoprotein receptor-related protein 8 (LRP8), a receptor of Reelin (the protein encoded by RELN), was significantly associated with schizophrenia and bipolar disorder in European populations.
|
28495490 |
2020 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Reelin is decreased in the postmortem brain in schizophrenia patients.
|
28583708 |
2020 |
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
These data confirm a significant role of endogenous reelin levels on stress-related behaviour, supporting a possible role in both bipolar disorder and schizophrenia.
|
28711473 |
2020 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
IN-derived Reelin has been associated with schizophrenia and temporal lobe epilepsy; however, the functional role of Reelin from INs is presently unclear.
|
31667489 |
2019 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Recent research has suggested a potential role for Reelin in the pathogenesis of neurological diseases such as schizophrenia, autism and Alzheimer's disease.
|
31022460 |
2019 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results revealed that, along with the RELN deletion, neuronal death was promoted in this patient; thus, neuronal death may be a vulnerable factor for schizophrenia.
|
31848032 |
2019 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our study provides and supports the evidence that RELN is a candidate gene for schizophrenia.
|
31469785 |
2019 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
There was no statistically significant association between the rs7341475 variant of RELN gene and schizophrenia in the overall population (χ<sup>2</sup> = 2.473, p = 0.290).
|
30980267 |
2019 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Besides LIS2 and ADLTE, <i>RELN</i> and/or other genes coding for the proteins of the Reln intracellular cascade have been associated substantially to other conditions such as spinocerebellar ataxia type 7 and 37, <i>VLDLR</i>-associated cerebellar hypoplasia, <i>PAFAH1B1</i>-associated lissencephaly, autism, and schizophrenia.
|
31805691 |
2019 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in RELN have been implicated in related disorders like autism and schizophrenia but have not been examined in dyslexia.
|
30199849 |
2018 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Human genetic studies suggest that rare RELN variants confer susceptibility to mental disorders such as schizophrenia.
|
30022058 |
2018 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The results of this study suggest that the expression of genes related to the reelin pathway could be different between individuals with SZ and MD and healthy controls, with a greater vulnerability associated with greater BMI.
|
29680575 |
2018 |
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
It has been suggested that reduced Reelin activity contributes to the pathogenesis of several neuropsychiatric and neurodegenerative disorders, such as schizophrenia and Alzheimer's disease; however, noninvasive methods that can upregulate Reelin activity <i>in vivo</i> have yet to be developed.
|
28213441 |
2017 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
TBR1 pioneer neurons and reelin, which guides cortico-petal migration, were restricted from the schizophrenia cortex.
|
30446636 |
2017 |
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We found that RELN rs736707 was significantly related with psychiatric disorders (schizophrenia, autism spectrum disorders and attention-deficit hyperactivity disorder) in Asian group (C vs T, OR=1.26, 95% CI=1.13-1.41, P<0.01, FDR<0.01), and rs7341475 was only significantly associated with reduced risk of schizophrenia in Caucasian (A vs G, OR=0.88, 95% CI=0.82-0.95, P<0.01, FDR<0.01).
|
28506622 |
2017 |
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Strikingly, dysregulation of Reelin or polySia expression is linked to schizophrenia.
|
27865768 |
2017 |
Schizophrenia
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Based upon the assumption of parallel methylation changes in the brain and peripheral blood, we concluded that RELN DNA methylation might contribute to the pathogenesis of schizophrenia.
|
28086126 |
2017 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Reelin (RELN) is identified as a risk gene for major psychiatric disorders such as schizophrenia (SCZ) and bipolar disorder (BPD).
|
26637325 |
2016 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Schizophrenia and reelin: a model based on prenatal stress to study epigenetics, brain development and behavior.
|
26968981 |
2016 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
They also showed specific changes in promoter DNA methylation activity of genes related to schizophrenia such as reelin, BDNF and GAD67, and altered expression and function of mGlu2/3 receptors in the frontal cortex.
|
26813121 |
2016 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our results provide genetic evidence that RELN may be one of pathogenic gene in SCZ.
|
27071546 |
2016 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The reelin gene is a strong candidate in the etiology of several psychiatric disorders such as schizophrenia, major depression, bipolar disorders, and autism spectrum disorders.
|
28127276 |
2016 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We report here, that the binding of DNMT1 to GABAergic (GAD1, RELN) and glutamatergic (BDNF-IX) promoters is increased in SZ and BP disorder patients and this increase does not necessarily correlate with enrichment in promoter methylation.
|
25476119 |
2015 |
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The authors recently reported that two enzymes that belong to the dynamic DNA methylation/demethylation network-DNMT (DNA methyltransferase) and TET (ten-eleven translocase; 5-hydroxycytosine translocator)-are abnormally increased in corticolimbic structures of SZ postmortem brain, suggesting a causal relationship between clinical manifestations of SZ and changes in DNA methylation and in the expression of SZ candidate genes (e.g., brain-derived neurotrophic factor [BDNF], glucocorticoid receptor [GCR], glutamic acid decarboxylase 67 [GAD67], reelin).
|
24702539 |
2015 |
Schizophrenia
|
0.700 |
Biomarker
|
disease |
MGD |
We investigated the effect of a 'two hit' combination of two factors implicated in schizophrenia development, reelin deficiency and stress, on cognitive behaviours in mice.
|
25845740 |
2015 |