RELN, reelin, 5649

N. diseases: 178; N. variants: 52
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE We recently found that the low-density lipoprotein receptor-related protein 8 (LRP8), a receptor of Reelin (the protein encoded by RELN), was significantly associated with schizophrenia and bipolar disorder in European populations. 28495490 2020
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE Reelin is decreased in the postmortem brain in schizophrenia patients. 28583708 2020
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 AlteredExpression disease BEFREE These data confirm a significant role of endogenous reelin levels on stress-related behaviour, supporting a possible role in both bipolar disorder and schizophrenia. 28711473 2020
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE IN-derived Reelin has been associated with schizophrenia and temporal lobe epilepsy; however, the functional role of Reelin from INs is presently unclear. 31667489 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE Recent research has suggested a potential role for Reelin in the pathogenesis of neurological diseases such as schizophrenia, autism and Alzheimer's disease. 31022460 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE Our results revealed that, along with the RELN deletion, neuronal death was promoted in this patient; thus, neuronal death may be a vulnerable factor for schizophrenia. 31848032 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE Our study provides and supports the evidence that RELN is a candidate gene for schizophrenia. 31469785 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE There was no statistically significant association between the rs7341475 variant of RELN gene and schizophrenia in the overall population (χ<sup>2</sup> = 2.473, p = 0.290). 30980267 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE Besides LIS2 and ADLTE, <i>RELN</i> and/or other genes coding for the proteins of the Reln intracellular cascade have been associated substantially to other conditions such as spinocerebellar ataxia type 7 and 37, <i>VLDLR</i>-associated cerebellar hypoplasia, <i>PAFAH1B1</i>-associated lissencephaly, autism, and schizophrenia. 31805691 2019
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE Polymorphisms in RELN have been implicated in related disorders like autism and schizophrenia but have not been examined in dyslexia. 30199849 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE Human genetic studies suggest that rare RELN variants confer susceptibility to mental disorders such as schizophrenia. 30022058 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE The results of this study suggest that the expression of genes related to the reelin pathway could be different between individuals with SZ and MD and healthy controls, with a greater vulnerability associated with greater BMI. 29680575 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 AlteredExpression disease BEFREE It has been suggested that reduced Reelin activity contributes to the pathogenesis of several neuropsychiatric and neurodegenerative disorders, such as schizophrenia and Alzheimer's disease; however, noninvasive methods that can upregulate Reelin activity <i>in vivo</i> have yet to be developed. 28213441 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE TBR1 pioneer neurons and reelin, which guides cortico-petal migration, were restricted from the schizophrenia cortex. 30446636 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE We found that RELN rs736707 was significantly related with psychiatric disorders (schizophrenia, autism spectrum disorders and attention-deficit hyperactivity disorder) in Asian group (C vs T, OR=1.26, 95% CI=1.13-1.41, P<0.01, FDR<0.01), and rs7341475 was only significantly associated with reduced risk of schizophrenia in Caucasian (A vs G, OR=0.88, 95% CI=0.82-0.95, P<0.01, FDR<0.01). 28506622 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 AlteredExpression disease BEFREE Strikingly, dysregulation of Reelin or polySia expression is linked to schizophrenia. 27865768 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 PosttranslationalModification disease BEFREE Based upon the assumption of parallel methylation changes in the brain and peripheral blood, we concluded that RELN DNA methylation might contribute to the pathogenesis of schizophrenia. 28086126 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE Reelin (RELN) is identified as a risk gene for major psychiatric disorders such as schizophrenia (SCZ) and bipolar disorder (BPD). 26637325 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE Schizophrenia and reelin: a model based on prenatal stress to study epigenetics, brain development and behavior. 26968981 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE They also showed specific changes in promoter DNA methylation activity of genes related to schizophrenia such as reelin, BDNF and GAD67, and altered expression and function of mGlu2/3 receptors in the frontal cortex. 26813121 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE Our results provide genetic evidence that RELN may be one of pathogenic gene in SCZ. 27071546 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE The reelin gene is a strong candidate in the etiology of several psychiatric disorders such as schizophrenia, major depression, bipolar disorders, and autism spectrum disorders. 28127276 2016
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE We report here, that the binding of DNMT1 to GABAergic (GAD1, RELN) and glutamatergic (BDNF-IX) promoters is increased in SZ and BP disorder patients and this increase does not necessarily correlate with enrichment in promoter methylation. 25476119 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 AlteredExpression disease BEFREE The authors recently reported that two enzymes that belong to the dynamic DNA methylation/demethylation network-DNMT (DNA methyltransferase) and TET (ten-eleven translocase; 5-hydroxycytosine translocator)-are abnormally increased in corticolimbic structures of SZ postmortem brain, suggesting a causal relationship between clinical manifestations of SZ and changes in DNA methylation and in the expression of SZ candidate genes (e.g., brain-derived neurotrophic factor [BDNF], glucocorticoid receptor [GCR], glutamic acid decarboxylase 67 [GAD67], reelin). 24702539 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease MGD We investigated the effect of a 'two hit' combination of two factors implicated in schizophrenia development, reelin deficiency and stress, on cognitive behaviours in mice. 25845740 2015