Autism Spectrum Disorders
|
0.400 |
Biomarker
|
disease |
BEFREE |
RELN is considered an important modulator for ASD, since there are several polymorphisms in this gene linked to the disease, and since lower levels of RELN have been reported in brains of ASD patients.
|
30668980 |
2019 |
Autism Spectrum Disorders
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic studies of human patients have demonstrated association between the RELN locus and autism spectrum disorder, schizophrenia, bipolar disorder, and Alzheimer's disease.
|
31607872 |
2019 |
Autism Spectrum Disorders
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to provide additional evidence for the association between two SNPs of RELN (i.e., rs736707, rs2229864) and ASD risk, as well as the relationship between RELN gene and symptom-based and developmental deficits of ASD patients in Chinese Han children and adolescents.
|
29753726 |
2018 |
Autism Spectrum Disorders
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings point to an abnormal interplay between Reelin-DAB1 and mTORC1 networks in nonsyndromic ASD.
|
29969175 |
2018 |
Autism Spectrum Disorders
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggest that both a deficiency in Reelin signaling and pathologic impairment of Reelin secretion may contribute to ASD risk.
|
28419454 |
2017 |
Autism Spectrum Disorders
|
0.400 |
Biomarker
|
disease |
CTD_human |
Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases.
|
28191889 |
2017 |
Autism Spectrum Disorders
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our data demonstrate that RELN, GAD1, and several other genes selectively expressed in GABAergic neurons, are down-regulated in post-mortem ASD FC.
|
28229923 |
2017 |
Autism Spectrum Disorders
|
0.400 |
Biomarker
|
disease |
BEFREE |
The reelin gene is a strong candidate in the etiology of several psychiatric disorders such as schizophrenia, major depression, bipolar disorders, and autism spectrum disorders.
|
28127276 |
2016 |
Autism Spectrum Disorders
|
0.400 |
Biomarker
|
disease |
BEFREE |
Reelin gene (RELN), which plays a crucial role in the migration and positioning of neurons during brain development, has been strongly posed as a candidate gene for ASD.
|
24453138 |
2014 |
Autism Spectrum Disorders
|
0.400 |
Biomarker
|
disease |
CTD_human |
Disrupted brain thyroid hormone homeostasis and altered thyroid hormone-dependent brain gene expression in autism spectrum disorders.
|
24781735 |
2014 |
Autism Spectrum Disorders
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, we detected a significant increase in TET1 expression and an enrichment in the level of 5-hmC, but not 5-mC, at the promoters of GAD1 and RELN in ASD when compared with CON.
|
24448211 |
2014 |
Autism Spectrum Disorders
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A significant genetic association between SNP2 (located in intron 59 of RELN) and ASD was observed, and the log-additive model was accepted as the best inheritance model fitting this data (OR: 0.72, 95% CI: 0.54-0.97, P = 0.03).
|
17955477 |
2008 |
Autism Spectrum Disorders
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic analysis of reelin gene (RELN) SNPs: no association with autism spectrum disorder in the Indian population.
|
18597938 |
2008 |
Autism Spectrum Disorders
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Reelin gene alleles and susceptibility to autism spectrum disorders.
|
12399956 |
2002 |