|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recent advances in research throw more lights of its beneficial role towards Alzheimer's disease (AD), including promoting β-amyloid (Aβ) clearance, as well as inhibiting Aβ production in the triple-transgenic mouse model of Alzheimer's disease (3×Tg AD).
|
31810131 |
2020 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Familial Alzheimer's disease (FAD)-associated presenilin 1 (PS1) serves as a catalytic subunit of γ-secretase complex, which mediates the proteolytic liberation of β-amyloid (Aβ) from β-amyloid precursor protein (APP).
|
30682043 |
2019 |
|
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The TgF344-AD rat model of AD, bearing mutant human amyloid precursor protein (APPswe) and Presenilin 1 (PSEN1ΔE9) genes, has been described to manifest the full spectrum of AD pathology similar to human AD, i.e. progressive cerebral amyloidosis, tauopathy, neuronal loss and age-dependent cognitive decline.
|
30445024 |
2019 |
|
Amyloidosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
This age-dependent shift in Aβ peptide profile coincided with reduced expression of glycosylated species of ADAM-10 (α-secretase) and BACE1 (β-secretase), and an increased co-immunoprecipitation of presenilin-1 with nicastrin (components of the γ-secretase complex).
|
30803762 |
2019 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We demonstrated that an antibiotic cocktail (ABX)-perturbed gut microbiome is associated with reduced amyloid-β (Aβ) plaque pathology and astrogliosis in the male amyloid precursor protein (<i>APP)<sub>SWE</sub></i> /presenilin 1 <i>(PS1)<sub>ΔE9</sub></i> transgenic model of Aβ amyloidosis.
|
31097468 |
2019 |
|
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here, we show that absence of TYROBP/DAP12 in a mouse model of AD-type cerebral Aβ amyloidosis (APP<sup>KM670/671NL</sup>/PSEN1<sup>Δexon9</sup>) recapitulates the expected network characteristics by normalizing the transcriptome of APP/PSEN1 mice and repressing the induction of genes involved in the switch from homeostatic microglia to disease-associated microglia (DAM), including Trem2, complement (C1qa, C1qb, C1qc, and Itgax), Clec7a and Cst7.
|
30283032 |
2019 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In particular, gene mutations of the γ-secretase complex-which contains presenilin 1 or 2 as the catalytic core-could trigger marked Aβ accumulation.
|
29097202 |
2018 |
|
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Moreover, in mice carrying an Alzheimer's disease-related mutation in presenilin 1, astrocytes accumulated GABA even in the absence of amyloidosis.
|
29107186 |
2018 |
|
Amyloidosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Recently, we reported that presenilin 1 considerably increased the expression level of U1 small nuclear RNA (snRNA) accompanied with the adverse change of amyloid precursor protein (APP) expression, β-amyloid (Aβ) production and cell apoptosis.
|
29395359 |
2018 |
|
Amyloidosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
AD-like phenotypes were altered by co-expression of PS1, including a shift from hippocampal to cortical Aβ pathology, alongside reduced deficits in spatial learning.
|
30040726 |
2018 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The protective action of the N-terminal Aβ fragment and Aβcore against spatial memory processing deficits in amyloid precursor protein/PSEN1 (5XFAD) mice was demonstrated in contextual fear conditioning.
|
29164616 |
2018 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Alzheimer's disease mouse models that overexpress amyloid precursor protein (APP) and presenilin 1 (PS1) form β-amyloid (Aβ) plaques, a hallmark Alzheimer's disease lesion.
|
30315100 |
2018 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Mutations in the human genes PRESENILIN1 (PSEN1), PRESENILIN2 (PSEN2) and AMYLOID BETA A4 PRECURSOR PROTEIN (APP) have been identified in familial Alzheimer's disease (AD).
|
28636676 |
2017 |
|
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Moreover, EW induced expression of stress-activated protein kinase p38 and presenilin 1 (PS1), the catalytic subunit of γ-secretase that produces the neurotoxic amyloid-β (Aβ) peptides Aβ40 and Aβ42.
|
28490448 |
2017 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Phosphorylated Presenilin 1 decreases β-amyloid by facilitating autophagosome-lysosome fusion.
|
28533369 |
2017 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study investigates the neuroprotective properties of berberine (a natural isoquinoline alkaloid isolated from the Rhizoma coptidis) and finds that berberine could promote β-amyloid (Aβ) clearance and inhibit Aβ production in the triple-transgenic mouse model of Alzheimer's disease (3×Tg-AD).
|
28223223 |
2017 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Crossing APP/PS1 mice with TRPC6 transgenic mice leads to a marked reduction in both plaque load and Aβ levels, and improvement in structural and behavioural impairment.
|
26581893 |
2015 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Spontaneous ARIA (amyloid-related imaging abnormalities) and cerebral amyloid angiopathy related inflammation in presenilin 1-associated familial Alzheimer's disease.
|
25408217 |
2015 |
|
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In the present study, treadmill exercise was initiated at a developed Aβ deposition stage in order to further investigate whether or not treadmill exercise in this phase can delay the progression of AD in aged APP/PS1 mice (17 months of age).
|
25917310 |
2015 |
|
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Relative ratio and level of amyloid-β 42 surrogate in cerebrospinal fluid of familial Alzheimer disease patients with presenilin 1 mutations.
|
24192669 |
2014 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In contrast, sleep deprivation or increasing wakefulness by rescue of orexinergic neurons in APP/PS1 mice lacking orexin increased the amount of Aβ pathology in the brain.
|
25422493 |
2014 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
In the present study, we evaluated the effects of a 3-month treatment course of trientine (Trien) on amyloidosis in 7-month-old β-amyloid (Aβ) precursor protein and presenilin-1 (APP/PS1) double transgenic (Tg) AD model mice.
|
23541064 |
2013 |
|
Amyloidosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We orally administered the flavonoid tannic acid (TA) to the transgenic PSAPP mouse model of cerebral amyloidosis (bearing mutant human APP and presenilin-1 transgenes) and evaluated cognitive function and AD-like pathology.
|
22219198 |
2012 |
|
Amyloidosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These findings show that Aβ precursor protein as well the activity of the γ-secretase are required to obtain the up-regulation of β-secretase which is induced by Presenilin 1 mutations.
|
22708832 |
2012 |
|
Amyloidosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The Aβ42-induced PS1 increase was abolished by siRNA AChE pretreatment, suggesting that AChE may participate in the pathological feedback loop between PS1 and Aβ.
|
21621296 |
2012 |