PSEN1, presenilin 1, 5663

N. diseases: 369; N. variants: 155
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.330 Biomarker disease BEFREE The results also revealed that the ACSS-FAD has good internal consistency, convergent validity (positive correlations with fear of suicide, death anxiety, and pain anxiety), and discriminant validity (no relation with depression). 28591462 2018
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.330 Biomarker disease PSYGENET These combined data support a physical interaction between PS-1 and MAO-A that could influence MAO-A activity and contribute to the monoaminergic disruptions common to disorders as seemingly diverse as depression and AD. 22045496 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.330 Biomarker disease PSYGENET Alzheimer disease-related presenilin-1 variants exert distinct effects on monoamine oxidase-A activity in vitro. 21373759 2011
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.330 Biomarker disease BEFREE For previously investigated candidate genes, some support (at a nominal significance level of 0.05/0.01) was found for association between NOS1 and personality traits (especially extraversion), PSEN1 and depression/neuroticism, and GRIK3 and depression. 20052609 2010
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.330 Biomarker disease PSYGENET For previously investigated candidate genes, some support (at a nominal significance level of 0.05/0.01) was found for association between NOS1 and personality traits (especially extraversion), PSEN1 and depression/neuroticism, and GRIK3 and depression. 20052609 2010
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.330 Biomarker disease PSYGENET Female preclinical presenilin-1 mutation carriers unaware of their genetic status have higher levels of depression than their non-mutation carrying kin. 14966176 2004
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.330 GeneticVariation disease BEFREE Female preclinical presenilin-1 mutation carriers unaware of their genetic status have higher levels of depression than their non-mutation carrying kin. 14966176 2004
CUI: C0011570
Disease: Mental Depression
Mental Depression
0.330 Biomarker disease PSYGENET APP processing and synaptic plasticity in presenilin-1 conditional knockout mice. 11567612 2001