PTAFR, platelet activating factor receptor, 5724

N. diseases: 96; N. variants: 6
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental
0.300 Biomarker disease CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136 2014
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome
0.300 Biomarker disease CTD_human Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles. 21411543 2011
CUI: C1136382
Disease: Sclerocystic Ovaries
Sclerocystic Ovaries
0.300 Biomarker disease CTD_human Progesterone resistance in PCOS endometrium: a microarray analysis in clomiphene citrate-treated and artificial menstrual cycles. 21411543 2011
CUI: C3665444
Disease: Neutrophilia (disorder)
Neutrophilia (disorder)
0.210 AlteredExpression disease BEFREE Antagonism of PAFR decreased lung neutrophilia, TNF, and IL-1β in an NLRP3 inflammasome-dependent manner. 30976089 2019
CUI: C3665444
Disease: Neutrophilia (disorder)
Neutrophilia (disorder)
0.210 Therapeutic disease RGD Scorpion venom-induced neutrophilia is inhibited by a PAF receptor antagonist in the rat. 10770284 2000
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy
0.200 Biomarker disease RGD Up-regulation of platelet-activating factor synthases and its receptor in spinal cord contribute to development of neuropathic pain following peripheral nerve injury. 22296727 2012
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Biomarker disease RGD Down-regulation of platelet-activating factor receptor gene expression during focal reversible cerebral ischemia in rats. 17268849 2007
CUI: C0520459
Disease: Necrotizing Enterocolitis
Necrotizing Enterocolitis
0.200 Therapeutic disease RGD Polyunsaturated fatty acid supplementation alters proinflammatory gene expression and reduces the incidence of necrotizing enterocolitis in a neonatal rat model. 17515866 2007
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia
0.200 Therapeutic phenotype RGD Antiinflammatory and antiallodynic actions of the lignan niranthin isolated from Phyllanthus amarus. Evidence for interaction with platelet activating factor receptor. 16925995 2006
CUI: C0009763
Disease: Conjunctivitis
Conjunctivitis
0.200 Biomarker disease RGD Direct action of platelet activating factor (PAF) induces eosinophil accumulation and enhances expression of PAF receptors in conjunctivitis. 15735601 2005
CUI: C0162557
Disease: Liver Failure, Acute
Liver Failure, Acute
0.200 Biomarker disease RGD Role of PAF in acute liver injury after extended hepatectomy: overexpression of PAF receptor mRNA in Kupffer cells. 11414308 2001
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury
0.200 Therapeutic disease RGD Effects of the PAF receptor antagonist UK74505 on local and remote reperfusion injuries following ischaemia of the superior mesenteric artery in the rat. 11139461 2000
CUI: C0151683
Disease: Neutrophilia (finding)
Neutrophilia (finding)
0.200 Therapeutic phenotype RGD Scorpion venom-induced neutrophilia is inhibited by a PAF receptor antagonist in the rat. 10770284 2000
CUI: C0026766
Disease: Multiple Organ Failure
Multiple Organ Failure
0.200 Therapeutic phenotype RGD Protective effects of a PAF receptor antagonist and a neutrophil elastase inhibitor on multiple organ failure induced by cerulein plus lipopolysaccharide in rats. 9750012 1998
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Therapeutic disease RGD Effect of the platelet-activating factor antagonist BN 50739 and its diluents on mitochondrial respiration and membrane lipids during and following cerebral ischemia. 8158141 1994
Other specified forms of pleural effusion, except tuberculous
0.200 Therapeutic disease RGD Interference of the PAF receptor antagonist, PCA 4248, with the rat pleurisy evoked by inflammatory mediators or allergen. 8395390 1993
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis
0.200 Therapeutic disease RGD Mechanisms of glomerular injury in experimental immune nephritis. II. Effect of a platelet activating factor receptor antagonist in an autologous nephritis model. 1668710 1991
CUI: C0036986
Disease: Shock, Traumatic
Shock, Traumatic
0.200 Therapeutic phenotype RGD Beneficial actions of BN 50739, a new PAF receptor antagonist, in murine traumatic shock. 2165204 1990
CUI: C0376618
Disease: Endotoxemia
Endotoxemia
0.200 Therapeutic phenotype RGD Platelet activating factor receptor antagonist improves survival and attenuates eicosanoid release in severe endotoxemia. 2178565 1990
CUI: C2609414
Disease: Acute kidney injury
Acute kidney injury
0.200 Therapeutic disease RGD Role of platelet activating factor in endotoxemic acute renal failure in the male rat. 2538527 1989
CUI: C0020649
Disease: Hypotension
Hypotension
0.200 Therapeutic phenotype RGD Platelet-activating factor (PAF) mediation of rat anaphylactic responses to soluble immune complexes. Studies with PAF receptor antagonist L-652,731. 3011900 1986
CUI: C0027947
Disease: Neutropenia
Neutropenia
0.200 Therapeutic disease RGD Platelet-activating factor (PAF) mediation of rat anaphylactic responses to soluble immune complexes. Studies with PAF receptor antagonist L-652,731. 3011900 1986
CUI: C0018498
Disease: Hair Color
Hair Color
0.100 GeneticVariation phenotype GWASCAT Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability. 30531825 2018
Low density lipoprotein cholesterol measurement
0.100 GeneticVariation phenotype GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
CUI: C0428474
Disease: Serum LDL cholesterol measurement
Serum LDL cholesterol measurement
0.100 GeneticVariation phenotype GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012