|
Carcinoma, Papillary
|
0.100 |
Biomarker
|
disease |
BEFREE |
- To detect histologic and molecular differences separating NIFTP from follicular adenomas (FAs) and invasive carcinomas, particularly papillary carcinomas with extensive follicular growth (PTC-EFGs) and invasive encapsulated PTC-FV (IE-PTC-FV).
|
29582677 |
2018 |
|
Carcinoma, Papillary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
RNA was isolated from multinodular goiter (MNG; n=6), papillary carcinoma (PTC, n=14), follicular carcinoma (FC; n=5), and Hürthle cell carcinoma (HCC; n=7).
|
24559275 |
2014 |
|
Carcinoma, Papillary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BRAF and RAS mutations and RET/PTC gene rearrangements were found in 65.1%, 0%, and 1.6% of papillary carcinomas, respectively.
|
24591770 |
2014 |
|
Carcinoma, Papillary
|
0.100 |
Biomarker
|
disease |
BEFREE |
In fact, it has been demonstrated that: a) RET/PTC is an early event in the process of thyroid carcinogenesis and has a critical role in the generation of the papillary carcinoma; b) RET/PTC activation is essentially restricted to the papillary histotype and to the Hürthle thyroid tumors; c) its incidence increases after exposure to radiations.
|
17891236 |
2007 |
|
Carcinoma, Papillary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Prevalence of RET/PTC rearrangements in thyroid papillary carcinomas: effects of the detection methods and genetic heterogeneity.
|
16772343 |
2006 |
|
Carcinoma, Papillary
|
0.100 |
Biomarker
|
disease |
BEFREE |
Chromosomal rearrangements involving the RET gene, known as RET/PTC, are prevalent in thyroid papillary carcinomas from patients with radiation history.
|
15671095 |
2005 |
|
Carcinoma, Papillary
|
0.100 |
Biomarker
|
disease |
BEFREE |
RET rearrangements are restricted to a well-differentiated papillary carcinoma, suggesting that RET/PTC positive papillary carcinomas do not progress to undifferentiated carcinoma.
|
15368067 |
2005 |
|
Carcinoma, Papillary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the prevalence of BRAF point mutations and RET/PTC rearrangements in 55 post-Chernobyl papillary carcinomas, compared with 82 sporadic papillary carcinomas.
|
15145515 |
2004 |
|
Carcinoma, Papillary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Employing in situ hybridization to detect INSL-3 transcripts and specific rabbit antisera against the INSL-3 proteins, both INSL-3 isoforms were detected in patients with Graves' disease (n=10), follicular carcinomas (FTC; n=12), papillary carcinomas (PTC; n=9) and undifferentiated anaplastic carcinomas (UTC; n=15).
|
12684664 |
2003 |
|
Carcinoma, Papillary
|
0.100 |
Biomarker
|
disease |
BEFREE |
Assessment of RET/PTC oncogene activation and clonality in thyroid nodules with incomplete morphological evidence of papillary carcinoma: a search for the early precursors of papillary cancer.
|
12057919 |
2002 |
|
Carcinoma, Papillary
|
0.100 |
Biomarker
|
disease |
BEFREE |
There is some evidence that different types of RET/PTC may be associated with distinct biologic properties of papillary carcinomas.
|
12114746 |
2002 |
|
Carcinoma, Papillary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the frequency and types of PTC genetic rearrangements in papillary carcinoma in a population of Hong Kong Chinese.
|
12457448 |
2002 |
|
Carcinoma, Papillary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The identification of ret/PTC gene rearrangements refined the diagnosis of PC in 9 of 15 specimens (60%) that would otherwise have been considered indeterminate and in 2 of 6 that were considered insufficient for cytological diagnosis.
|
11344225 |
2001 |
|
Carcinoma, Papillary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Papillary carcinomas show frequently a specific gene rearrangement which gives rise to the formation of several types of so-called RET/PTC chimeric genes.
|
10834397 |
2000 |
|
Carcinoma, Papillary
|
0.100 |
Biomarker
|
disease |
BEFREE |
The frequency, if we consider exclusively the papillary carcinomas, is in both cases 12%; (b) show that the TRK oncogene plays a role in the development of a minority of radiation-associated papillary thyroid carcinomas but not in adenomas; and (c) confirm that RET/PTC rearrangements are the major genetic alteration associated with ionizing radiation-induced thyroid tumorigenesis.
|
10646882 |
2000 |
|
Carcinoma, Papillary
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together these results support the concept that RET/PTC activation plays a central role in the pathogenesis of thyroid papillary carcinomas in both Ukraine and Belarus after the Chernobyl accident.
|
10566678 |
1999 |
|
Carcinoma, Papillary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present data do not support a major geographic difference in the prevalence of ret/PTC rearrangements in papillary carcinomas between Japan, the United States, and Italy.
|
9669285 |
1998 |
|
Carcinoma, Papillary
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study demonstrates that all thyroid carcinomas harboring activating RET rearrangements exhibit a well-differentiated phenotype, that of papillary carcinoma, and indicates that the subset of RET/PTC-positive papillary carcinomas do not progress to more aggressive, less differentiated tumor phenotypes.
|
9516913 |
1998 |
|
Carcinoma, Papillary
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of the RET/PTC fusion gene as a marker for papillary carcinoma in Hashimoto's thyroiditis.
|
9001272 |
1997 |
|
Carcinoma, Papillary
|
0.100 |
Biomarker
|
disease |
BEFREE |
RET/PTC oncogene activation occurs in about 20% of human thyroid papillary carcinomas.
|
7566982 |
1995 |
|
Carcinoma, Papillary
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study questions the relevance of PTC/retTPC oncogene in the carcinogenesis of thyroid papillary carcinomas in the Saudi population.
|
8275421 |
1994 |
|
Carcinoma, Papillary
|
0.100 |
Biomarker
|
disease |
BEFREE |
We did not find any ret transcripts in papillary carcinomas negative for PTC activation, nor in normal thyroid and in non-papillary thyroid neoplasias.
|
1457350 |
1992 |
|
Carcinoma, Papillary
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the PTC/retTPC chimeric transcripts were detected in two PCs with the rearrangement by reverse transcription polymerase chain reaction.
|
1620547 |
1992 |
|
Carcinoma, Papillary
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have recently reported the identification of a new oncogene, named PTC, frequently activated in human thyroid papillary carcinomas.
|
1701232 |
1990 |