melanoma
|
0.800 |
PosttranslationalModification
|
disease |
BEFREE |
Somatic oncogenic mutation of BRAF coupled with inactivation of PTEN constitute a frequent combination of genomic alterations driving the development of human melanoma.
|
31065107 |
2020 |
melanoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
PTEN immunohistochemical loss, a common event in endometrioid-type endometrial carcinoma and associated with local immune suppression in melanoma, was not associated with PD-L1 expression or lymphocyte/macrophage infiltration of the tumor.
|
30291344 |
2019 |
melanoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Synthetic lethality of a cell-penetrating anti-RAD51 antibody in PTEN-deficient melanoma and glioma cells.
|
30863489 |
2019 |
melanoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
The dCas9-VPR system increased PTEN expression in melanoma and TNBC cell lines, without transcriptional regulation at predicted off-target sgRNA binding sites.
|
30654190 |
2019 |
melanoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
PTEN genomic alterations (deletion, mutation), promoter methylation, and protein destabilization did not fully explain PTEN loss in melanoma, whereas PTEN levels increased with treatment of melanoma cells with the histone deacetylase inhibitor LBH589.
|
30148988 |
2019 |
melanoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
C-Jun drives melanoma progression in PTEN wild type melanoma cells.
|
31378787 |
2019 |
melanoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We also evaluated the antitumor activity of an anti-OX40 antibody plus PI3Kβ inhibition in a transgenic murine melanoma model (<i>Braf</i> mutant, PTEN null), which spontaneously develops immunotherapy-resistant melanomas.
|
31371342 |
2019 |
melanoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of somatic mutations in BRAF (96%) and PTEN (36%) in the AYA WGS cohort were double the rates observed in adult melanomas (Q < 6.0 × 10<sup>-6</sup> and 0.028, respectively).
|
30178487 |
2019 |
melanoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
MiR-637 suppresses melanoma progression through directly targeting P-REX2a and inhibiting PTEN/AKT signaling pathway.
|
30213289 |
2018 |
melanoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Additionally, p62 forms a feedback loop with PTEN in melanoma cells, suggesting p62 functions as an oncogene in UVA-associated melanoma development and progression.
|
28715145 |
2018 |
melanoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
The metformin/sitagliptin combination was effective in a BRAFV600E/PTEN tamoxifen-inducible murine melanoma model.
|
29899823 |
2018 |
melanoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Moreover, we identified AXL as a key upstream effector of AKT pathway-associated resistance to BRAFi in melanoma with wildtype PTEN, but not in melanoma with impaired PTEN.
|
29551771 |
2018 |
melanoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Functional and genomic analyses of patient-derived melanomas revealed that PTEN loss is associated with NHEJ deficiency.
|
29739874 |
2018 |
melanoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Suppression of MAPK signaling in BRAF-activated PTEN-deficient melanoma by blocking β-catenin signaling in cancer-associated fibroblasts.
|
29045061 |
2018 |
melanoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We observe selection for low-abundance PTEN variants in cancer, and show that p.Pro38Ser, which accounts for ~10% of PTEN missense variants in melanoma, functions via a dominant-negative mechanism.
|
29785012 |
2018 |
melanoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Moreover, miR-331 suppressed the activation of the PTEN/AKT signalling pathway in melanoma by inhibiting AEG-1.
|
29510779 |
2018 |
melanoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
<i>PHIP</i> copy number was enriched in metastatic melanomas harboring mutant <i>NRAS</i> or expressing PTEN protein (cohort No.2).
|
29776954 |
2018 |
melanoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Co-treatment of phenformin enhances the effect of anti-PD-1 antibody therapy on inhibiting tumor growth in the BRAF V600E/PTEN-null melanoma mouse model.
|
28433543 |
2017 |
melanoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Thus, these data not only provide mechanistic insight into Abl/Arg regulation during melanoma development, but also pave the way for the development of new strategies for treating patients with melanomas harboring mutant BRAF/PTEN, which often are refractory to current therapies.
|
28368422 |
2017 |
melanoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Treatment with ST-162 produced regression of mutant KRAS- or BRAF-addicted xenograft models of colorectal cancer and melanoma and stasis of BRAF/PTEN-mutant melanomas.
|
28775144 |
2017 |
melanoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Here, we show that concurrent loss of PTEN and activation of the Notch pathway is associated with poor response to the ERK inhibitor SCH772984, and that co-inhibition of Notch and ERK decreased viability in BRAF-V600E melanomas.
|
27655717 |
2016 |
melanoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Analysis of a melanoma tissue microarray showed loss of PTEN expression to predict for a lower overall survival, with a trend for even lower survival being seen when loss of fibronectin was included in the analysis.
|
26073081 |
2016 |
melanoma
|
0.800 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings provide a strong rationale for testing combinations of panPI3K, PI3Kβ + IGF1R, and MAPK pathway inhibitors in PTEN(LOF)/BRAF(MUT) melanoma patients to achieve maximal response.
|
26577700 |
2016 |
melanoma
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We demonstrate that SAR260301 blocks PI3K pathway signaling preferentially in PTEN-deficient human tumor models, and has synergistic antitumor activity when combined with vemurafenib (BRAF inhibitor) or selumetinib (MEK inhibitor) in PTEN-deficient/BRAF-mutated human melanoma tumor models.
|
27196754 |
2016 |
melanoma
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Peng and colleagues describe the effects of PTEN inactivation on antitumor immunity and response to immune checkpoint blockade in melanoma.
|
26851183 |
2016 |