Squamous cell carcinoma of the head and neck
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
miR-96-5p targets PTEN expression affecting radio-chemosensitivity of HNSCC cells.
|
30925916 |
2019 |
Squamous cell carcinoma of the head and neck
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
The most common abnormalities downstream from EGFR in HNSCC are in the PI3K pathway, activated via loss of expression of the regulator PTEN, or via PI3K mutation.
|
30926065 |
2019 |
Squamous cell carcinoma of the head and neck
|
0.800 |
Biomarker
|
disease |
BEFREE |
Here we explore the impact of hypoxia on the behavior of HNSCC and define that the controlling function of phosphatase and tensin homolog (PTEN) over HIF-1α expression and CSC accumulation are de-regulated during hypoxic events.
|
31560860 |
2019 |
Squamous cell carcinoma of the head and neck
|
0.800 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to evaluate the prognostic and predictive impact of PTEN, cMET, and p16 expression in recurrent HNSCC.
|
30478503 |
2018 |
Squamous cell carcinoma of the head and neck
|
0.800 |
GeneticVariation
|
disease |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
Squamous cell carcinoma of the head and neck
|
0.800 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to determine whether single nucleotide polymorphisms (SNPs) in AKT1, AKT2, FRAP1, PIK3CA, and PTEN were associated with treatment response and clinical outcome in patients with head and neck squamous cell carcinoma (HNSCC).
|
24421178 |
2015 |
Squamous cell carcinoma of the head and neck
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
We hypothesize that the loss of PTEN expression as well as the subcellular localization could be of interest as a predictive marker of recurrence in HNSCC.
|
24366426 |
2014 |
Squamous cell carcinoma of the head and neck
|
0.800 |
Biomarker
|
disease |
CTD_human |
The dual pathway inhibitor rigosertib is effective in direct patient tumor xenografts of head and neck squamous cell carcinomas.
|
23873848 |
2013 |
Squamous cell carcinoma of the head and neck
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Overall, our study highlights the likely clinical relevance of reduced PTEN expression and/or inactivation in HNSCC progression, while the combined Pten deletion with exposure to tobacco carcinogens or their surrogates may provide a unique experimental model system to study novel molecular targeted treatments for HNSCC patients.
|
23633918 |
2013 |
Squamous cell carcinoma of the head and neck
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Tbx3 represses PTEN and is over-expressed in head and neck squamous cell carcinoma.
|
23082988 |
2012 |
Squamous cell carcinoma of the head and neck
|
0.800 |
Biomarker
|
disease |
BEFREE |
Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation.
|
22037217 |
2012 |
Squamous cell carcinoma of the head and neck
|
0.800 |
Biomarker
|
disease |
BEFREE |
In addition, miR-9 may function as a tumor suppressor in HNSCC through inhibition of cell proliferation and elevation of tumor suppressor PTEN.
|
22133638 |
2012 |
Squamous cell carcinoma of the head and neck
|
0.800 |
Biomarker
|
disease |
BEFREE |
Mutations in the genes associated with the PI3K/AKT pathway including PI3K, AKT, RAS and PTEN, are infrequently found within head and neck squamous cell carcinoma and more specifically are rarely reported in oral squamous cell carcinoma (OSCC) cases.
|
21824802 |
2011 |
Squamous cell carcinoma of the head and neck
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
To investigate the role of PTEN loss of expression in head and neck squamous cell carcinoma (HNSCC) response to cetuximab, we used siRNA in Cal 27 cells and then evaluated key signaling protein activation (pAKT and pERK 1/2) as well as cell viability and proliferation.
|
21042725 |
2010 |
Squamous cell carcinoma of the head and neck
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Activation of the PI3K/AKT/mTOR pathway downstream to kinase receptors, such as EGFR, was found in 57-81% of head and neck squamous cell carcinoma (HNSCC), and was eventually associated with a loss of PTEN function. mTOR was shown to modulate cell proliferation, apoptosis, invasion, and angiogenesis.
|
17912526 |
2008 |
Squamous cell carcinoma of the head and neck
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that nAChRs might exert their function through pathways different from PI3-K/Akt/PTEN and that alpha3, alpha5 or alpha7 nAChR subunit expression might not be useful prognostic markers in HNSCC.
|
17465209 |
2007 |
Squamous cell carcinoma of the head and neck
|
0.800 |
Biomarker
|
disease |
BEFREE |
Dysregulation of the PI 3-K/AKT/PTEN pathway might contribute to early HNSCC tumorigenesis and might constitute a potential clinical target.
|
15543611 |
2005 |
Squamous cell carcinoma of the head and neck
|
0.800 |
Biomarker
|
disease |
CTD_human |
Detection of new PTEN/MMAC1 mutations in head and neck squamous cell carcinomas with loss of chromosome 10.
|
11801303 |
2002 |
Squamous cell carcinoma of the head and neck
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
Detection of new PTEN/MMAC1 mutations in head and neck squamous cell carcinomas with loss of chromosome 10.
|
11801303 |
2002 |
Squamous cell carcinoma of the head and neck
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We sequenced the entire coding region of the PTEN/MMAC1 gene in the remaining tumors displaying loss of heterozygosity and found one terminating mutation in a HNSCC sample.
|
9458098 |
1998 |
Squamous cell carcinoma of the head and neck
|
0.800 |
Biomarker
|
disease |
BEFREE |
Our results suggest that PTEN may play a role in the genesis of some SCCHNs.
|
9688299 |
1998 |
Squamous cell carcinoma of the head and neck
|
0.800 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Multiple hamartoma syndrome (Cowden's disease).
|
4635800 |
1972 |
Squamous cell carcinoma of the head and neck
|
0.800 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Squamous cell carcinoma of the head and neck
|
0.800 |
CausalMutation
|
disease |
CGI |
|
|
|