Epilepsy
0.320
Biomarker
disease
BEFREE
This second region comprises about 3 Mb and contains the candidate gene SLC4A10 , providing further support for the potential role of this gene in epilepsy .
21204806
2010
Epilepsy
0.320
Biomarker
disease
BEFREE
SLC4A10 is the third SLC4 base transporter family member to be implicated in human cognition and epilepsy .
18413482
2008
Epilepsy
0.320
Therapeutic
disease
CTD_human
Hence, Slc4a10 is a promising pharmacological target for the therapy of epilepsy or elevated intracranial pressure.
18165320
2008
Intellectual Disability
0.310
Biomarker
group
BEFREE
Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation .
18413482
2008
Intellectual Disability
0.310
Biomarker
group
CTD_human
Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation .
18413482
2008
Cognition Disorders
0.300
Biomarker
group
CTD_human
Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation.
18413482
2008
Profound Mental Retardation
0.300
Biomarker
disease
CTD_human
Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation.
18413482
2008
Mental Retardation, Psychosocial
0.300
Biomarker
phenotype
CTD_human
Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation.
18413482
2008
Epilepsy, Frontal Lobe
0.300
Biomarker
disease
CTD_human
Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation.
18413482
2008
Epilepsy, Cryptogenic
0.300
Therapeutic
disease
CTD_human
Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability.
18165320
2008
Intracranial Hypertension
0.300
Therapeutic
disease
CTD_human
Hence, Slc4a10 is a promising pharmacological target for the therapy of epilepsy or elevated intracranial pressure .
18165320
2008
×
CUI:
C0236018
Disease:
Aura
Aura
0.300
Therapeutic
phenotype
CTD_human
Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability.
18165320
2008
Frontal Epilepsy, Benign, Childhood
0.300
Biomarker
disease
CTD_human
Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation.
18413482
2008
Epilepsy, Supplementary Motor
0.300
Biomarker
disease
CTD_human
Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation.
18413482
2008
Epilepsy, Cingulate
0.300
Biomarker
disease
CTD_human
Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation.
18413482
2008
Epilepsy, Opercular
0.300
Biomarker
disease
CTD_human
Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation.
18413482
2008
Awakening Epilepsy
0.300
Therapeutic
disease
CTD_human
Mice with targeted Slc4a10 gene disruption have small brain ventricles and show reduced neuronal excitability.
18165320
2008
Epilepsy, Anterior Fronto-Polar
0.300
Biomarker
disease
CTD_human
Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation.
18413482
2008
Epilepsy, Orbito-Frontal
0.300
Biomarker
disease
CTD_human
Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation.
18413482
2008
Mental deficiency
0.300
Biomarker
disease
CTD_human
Disruption of sodium bicarbonate transporter SLC4A10 in a patient with complex partial epilepsy and mental retardation.
18413482
2008
Schizophrenia
0.110
GeneticVariation
disease
GWASCAT
Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.
31374203
2019
Schizophrenia
0.110
GeneticVariation
disease
GWASCAT
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection.
29483656
2018
Schizophrenia
0.110
GeneticVariation
disease
BEFREE
Based on conjunctional FDR < 0.05, we identified 2 loci shared between SCZ and ICV implicating genes FOXO3 (rs10457180 ) and ITIH4 (rs4687658 ), 2 loci shared between SCZ and hippocampal volume implicating SLC4A10 (rs4664442 ) and SPATS2L (rs1653290 ), and 2 loci shared between SCZ and volume of putamen implicating DCC (rs4632195 ) and DLG2 (rs11233632 ).
29136250
2018
Intelligence
0.100
GeneticVariation
phenotype
GWASCAT
A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.
29326435
2019
Intelligence
0.100
GeneticVariation
phenotype
GWASCAT
Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.
31374203
2019