Renal Cell Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In summary, the results indicate that activation of the COX-2-PGE2 pathway in RCC leads to the development of sunitinib resistance and may serve an important role in the maintenance of the characteristics of stem cells that are closely associated with drug resistance.
|
31423209 |
2019 |
Renal Cell Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The isolated compound HEG can impart momentous chemo-protection against experimental RCC by suppressing the cyclooxygenase (COX-2) and prostaglandin E2 (PGE<sub>2</sub>) expression via nuclear factor-kappa B (NF-κB) pathway.
|
28155120 |
2017 |
Renal Cell Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
To observe the the potential benefit of sunitinib in combination with cyclooxygenase-2(COX-2) inhibitor in renal cell carcinoma therapy.
|
27926489 |
2017 |
Renal Cell Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
RCC tissue chips were subjected to IHC staining, which showed COX-2 expression in RCC tissues to be a significantly closely correlated with NOV expression, with significance determined using Pearson correlation testing (P < 0.05).
|
25973014 |
2015 |
Renal Cell Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The role of functional polymorphisms of cyclooxygenase 2 in renal cell carcinoma.
|
25275044 |
2014 |
Renal Cell Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thus, COX-2 and CAIX seem to be important predictors of outcome in patients with metastatic RCCs and might enhance the prognostic information obtained from pathology specimens.
|
18976937 |
2010 |
Renal Cell Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Immunohistochemically, overexpression of iNOS (p < 0.0001) and COX-2 (p = 0.0002) was more frequently observed in dialysis RCC.
|
17451187 |
2007 |
Renal Cell Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results demonstrate that the generated COX-2 in human renal cell carcinoma plays an important role in the proliferation of malignant renal cells.
|
14719128 |
2004 |
Renal Cell Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
A human RCC cell line that expresses COX-2 was transfected with COX-2 sense or antisense cDNA.
|
15538221 |
2004 |
Renal Cell Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
COX-2 protein in RCC was not altered in comparison with normal renal tissue.
|
15569051 |
2004 |
Renal Cell Carcinoma
|
0.600 |
Biomarker
|
disease |
LHGDN |
Our study demonstrates that COX-2 is overexpressed in OS-RC-2 RCC cell line and plays an important role in tumorigenesis of the cells in vivo, which implies that COX-2 may be a therapeutic target for COX-2-expressing RCC, and that suppression of COX-2 expression by antisense-based strategy may have potential utility in treatment of COX-2-expressing RCC.
|
14712483 |
2004 |
Renal Cell Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
COX-2 overexpression within these intracellular organelles in RCC may be associated with renal cell carcinogenesis and COX-2 may be a useful biomarker in RCC.
|
15049901 |
2004 |
Renal Cell Carcinoma
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
COX-2 protein in RCC was not altered in comparison with normal renal tissue.
|
15569051 |
2004 |
Renal Cell Carcinoma
|
0.600 |
Biomarker
|
disease |
RGD |
In total, Cox-2 mRNA expression was down-regulated in eight out of ten Eker RCs and cell lines, while Cox-1 mRNA expression was up-regulated in nine out of ten Eker RCs and cell lines.
|
12708469 |
2003 |
Renal Cell Carcinoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
Expression of cycloxygenase-2 in human bladder and renal cell carcinoma.
|
12664575 |
2002 |