Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Risks of colorectal neoplasms and cardiovascular thromboembolic events after the combined use of selective COX-2 inhibitors and aspirin with 5-year follow-up: a meta-analysis.
|
30656820 |
2019 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
However, the downstream prostaglandin (PG)-PG receptor pathway involved in these effects is poorly characterized.We studied the PG-pathway in gene expression databases and we found that PTGS2 (prostaglandin G/H synthase and cyclooxygenase) and PTGES (prostaglandin E synthase) are co-expressed in human colorectal tumors.
|
26498686 |
2015 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Levels of COX-2 mRNA are found over-expressed in almost 80% of the colorectal tumors, compared to paired adjacent normal colorectal mucosa, suggesting a role of COX-2 as a potential biomarker for cancer risk, whereas inhibitors of COX-2 could be of value in chemoprevention of colon cancer.
|
24383454 |
2014 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
COX-2 overexpression is a frequent, but not universal event in colorectal neoplasms.
|
21158711 |
2011 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Cyclooxygenase-2 expression and recurrence of colorectal adenomas: effect of aspirin chemoprevention.
|
20427397 |
2010 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Bioactive metabolites downstream of cyclooxygenase-2 (COX-2) generated prostaglandin H(2) (PGH(2)), in particular prostaglandin E(2) (PGE(2)), are thought to play critical roles during the development of colorectal tumors.
|
19035518 |
2009 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Aspirin use and survival after diagnosis of colorectal cancer.
|
19671906 |
2009 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Detection of colorectal cancer cells from feces using quantitative real-time RT-PCR for colorectal cancer diagnosis.
|
19016757 |
2008 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Proline oxidase, a p53-induced gene, targets COX-2/PGE2 signaling to induce apoptosis and inhibit tumor growth in colorectal cancers.
|
18794809 |
2008 |
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Polymorphisms in cyclooxygenase-2 and epidermal growth factor receptor are associated with progression-free survival independent of K-ras in metastatic colorectal cancer patients treated with single-agent cetuximab.
|
19047118 |
2008 |
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer.
|
17151091 |
2007 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Expression of cyclooxygenase-2 and its relationship to p53 accumulation in colorectal cancers.
|
17594159 |
2007 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
An upstream CRE-E-box element is essential for gastrin-dependent activation of the cyclooxygenase-2 gene in human colon cancer cells.
|
17604853 |
2007 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Coexpression of VEGF-C and Cox-2 in human colorectal cancer and its association with lymph node metastasis.
|
16474989 |
2006 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia.
|
16818642 |
2006 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Combined analysis of COX-2 and p53 expressions reveals synergistic inverse correlations with microsatellite instability and CpG island methylator phenotype in colorectal cancer.
|
16820091 |
2006 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Prostaglandin E2 enhances intestinal adenoma growth via activation of the Ras-mitogen-activated protein kinase cascade.
|
15753380 |
2005 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Overexpression of COX-2 and iNOS mRNA expression was observed in 42.2% and 66.7% of the 90 colorectal tumors, respectively.
|
15695237 |
2005 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Lysophosphatidic acid transactivates both c-Met and epidermal growth factor receptor, and induces cyclooxygenase-2 expression in human colon cancer LoVo cells.
|
16237757 |
2005 |
Colorectal Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Analysis of K-ras mutations and expression of cyclooxygenase-2 and gastrin protein in laterally spreading tumors.
|
16174078 |
2005 |
Colorectal Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Cyclooxygenase-2 expression in primary human colorectal cancers and bone marrow micrometastases.
|
15248379 |
2004 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
RNA profiling of cyclooxygenases 1 and 2 in colorectal cancer.
|
15328521 |
2004 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Cyclooxygenase-2 activation mediates the proangiogenic effect of nitric oxide in colorectal cancer.
|
15102673 |
2004 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In addition, overexpression of COX-2 was found more frequently in colorectal tumors with lymphatic invasion, regional lymph node metastasis and larger size, although without statistical significance.
|
15075004 |
2004 |
Colorectal Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Cyclooxygenase 2 (COX-2) is overexpressed frequently in aerodigestive tumors, especially in colorectal tumors.
|
15300574 |
2004 |