PTGS2, prostaglandin-endoperoxide synthase 2, 5743

N. diseases: 1234; N. variants: 27
Disease: Depressive disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 AlteredExpression disease BEFREE 1 L-1β, TNF-α and COX-2), increased BDNF expression and neurogenesis, restored the dysfunction of ATP production and oxidative stress in inflammation- induced depression. 31022424 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE These findings suggest that selective inhibition of COX-2 ameliorates depression-like behaviors in rat models of depression. 31539536 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE Cytosolic phospholipase A2 (cPLA2) and cyclo-oxygenase-2 (COX-2) are the key enzymes in the metabolism of polyunsaturated fatty acids (PUFAs), which in turn may play an important role in inflammation and somatic symptoms in depression. 28108057 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE AD and depression are crucially linked by neuroinflammation and cyclooxygenase II (COX-2) enzyme involvement is an intriguing field of research. 29879605 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression. 30526621 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 AlteredExpression disease BEFREE PCNA, Ki-67 and COX-2 expression in cancer tissues of the patient group had no correlation with the existence of lumps and localized density-increased shadows (p>0.05), but were associated with manifestations of architectural distortion, calcification as well as skin and nipple depression (p<0.05). 28927045 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE An imbalance in the cortical COX2-PGE2-cAMP/PKA-CREB-BDNF signalling pathway participates in the pathogenic mechanism of depression. 28352129 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE The potential of various anti-inflammatory approaches such as selective cyclooxygenase-2 inhibitors, inflammatory cytokine inhibitors, and indoleamine 2,3-dioxygenase inhibitors pertaining to their serotonin restoring effects is discussed as possible therapy for treatment of depression in epilepsy. 28038393 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease BEFREE There is also some evidence indicative of a role of genetic variants of the enzymes, Cyclo-oxygenase2 (COX-2) and Phospholipase2 (PLA2), in the aetiology of depression. 22580182 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease PSYGENET There is also some evidence indicative of a role of genetic variants of the enzymes, Cyclo-oxygenase2 (COX-2) and Phospholipase2 (PLA2), in the aetiology of depression. 22580182 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease PSYGENET Polymorphism -765 G/C in COX-2-encoding gene promoter is associated with development of Alzheimer's disease, depression, carcinoma of the pancreas in smokers, breast cancer and rheumatoid arthritis. 21655952 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 GeneticVariation disease BEFREE Polymorphism -765 G/C in COX-2-encoding gene promoter is associated with development of Alzheimer's disease, depression, carcinoma of the pancreas in smokers, breast cancer and rheumatoid arthritis. 21655952 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease PSYGENET The expression of genes encoding for COX-2, MPO, iNOS, and sPLA2-IIA in patients with recurrent depressive disorder. 22331023 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 AlteredExpression disease BEFREE Cyclooxygenase-2 (COX-2), the expression of which increases in depression, is an enzyme involved in inflammation and free radical processes. 20588070 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease PSYGENET Genetic variations in the COX2 and PLA2 genes increase the risk of IFN-alpha-induced depression, possibly by affecting the levels of EPA and DHA. 20034614 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 GeneticVariation disease BEFREE Participants with the PLA2 BanI GG or the COX2 rs4648308 AG genotypes had a higher risk of IFN-alpha-induced depression (odds ratio = 3.1 and 3.5, respectively). 20034614 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease PSYGENET Cyclooxygenase-2 (COX-2), the expression of which increases in depression, is an enzyme involved in inflammation and free radical processes. 20588070 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 Biomarker disease CTD_human Furthermore, these data indicate that chronic celecoxib treatment reverse chronic unpredictable stress-induced depressive-like behavior might via reducing COX-2 enzyme in brain, and the selective COX-2 inhibitors could be developed as potential remedies for the management of depression. 19356723 2009
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.600 AlteredExpression disease BEFREE COX-2 overexpression was observed in 12 of 77 (15.6%) DP and there was no significant difference between DPdep (3 of 23, 13.0%) and DPpo (9 of 54, 16.7%). 12397273 2002