PTHLH, parathyroid hormone like hormone, 5744

N. diseases: 321; N. variants: 5
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.390 AlteredExpression group BEFREE CD11b(+)Gr1(+) cells isolated from mice with PTHrP-overexpressing tumors exhibited relatively increased proangiogenic potential, suggesting that prostate tumor-derived PTHrP potentiates this activity of CD11b(+)Gr1(+) cells. 24072746 2013
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.390 Biomarker group LHGDN Tumor expressed PTHrP facilitates prostate cancer-induced osteoblastic lesions. 18729185 2008
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.390 Biomarker group CTD_human Prostate cancer cell type-specific involvement of the VDR and RXR in regulation of the human PTHrP gene via a negative VDRE. 16243370 2006
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.390 AlteredExpression group LHGDN Direct evidence that PTHrP expression promotes prostate cancer progression in bone. 15629138 2005
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.390 Biomarker group BEFREE These results suggest that PTHrP may play a role in prostate tumor invasion and metastasis by influencing cell adhesion to the ECM via upregulation of specific integrin subunits. 12581888 2003
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.390 Biomarker group BEFREE These findings indicate that PTHrP may play a role in prostate tumor invasion and metastasis by upregulating the expression of specific integrin subunits via an intracrine pathway. 12686457 2003
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.390 AlteredExpression group LHGDN Prostate cancer cell type-specific regulation of the human PTHrP gene via a negative VDRE. 12850281 2003
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.390 AlteredExpression group BEFREE Parathyroid hormone-related protein (PTHrP) is expressed by human prostatic tissue and prostate cancer cell lines, and positively influences primary prostate tumor growth in vivo. 11891011 2002
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.390 Biomarker group BEFREE It is therefore possible that PTHrP regulates prostate tumor cell proliferation via ODC gene expression. 12230264 2001
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.390 AlteredExpression group BEFREE The MatLyLu rat prostate carcinoma model was used to determine the effects of PTHrP overexpression on prostate tumor growth. 10606251 1999