Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4317109
Disease: Epileptic Seizures
Epileptic Seizures
0.320 AlteredExpression phenotype BEFREE KCC2 downregulation facilitates epileptic seizures. 28279020 2017
CUI: C4317109
Disease: Epileptic Seizures
Epileptic Seizures
0.320 Biomarker phenotype CTD_human A thallium transport FLIPR-based assay for the identification of KCC2-positive modulators. 20086212 2010
CUI: C4317109
Disease: Epileptic Seizures
Epileptic Seizures
0.320 Biomarker phenotype BEFREE We conclude that the anomalous expression of both Cl(-) transporters, NKCC1 and KCC2 [corrected] in TLE hippocampal subiculum probably causes altered Cl(-) transport in the "epileptic" neurons, as revealed in the microtransplanted Xenopus oocytes, and renders GABA aberrantly "exciting," a feature that may contribute to the precipitation of epileptic seizures. 16709666 2006